- Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
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Kim MJ, Kim NY, Jung YA, Lee S, Jung GS, Kim JG, Lee IK, Lee S, Choi YK, Park KG
- KMID: 2470966
- Diabetes Metab J.
- 2020 Feb;44(1):186-192.
- doi: 10.4093/dmj.2018.0271
Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect... -
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- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C
- KMID: 2470964
- Diabetes Metab J.
- 2020 Feb;44(1):158-172.
- doi: 10.4093/dmj.2018.0235
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated... -
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- Clinicopathological Significance of SMAD4 Expression in Breast Cancer
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Woo JS, Chung MS, Paik SS
- KMID: 2470603
- J Breast Dis.
- 2019 Dec;7(2):52-58.
- doi: 10.14449/jbd.2019.7.2.52
PURPOSE: SMAD4 is a member of the SMAD family and acts as a central mediator of transforming growth factor beta signaling. Little is known about SMAD4 expression and its prognostic... -
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- Shen-Kang protects against tacrolimus-induced renal injury
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Zhang LY, Jin J, Luo K, Piao SG, Zheng HL, Jin JZ, Lim SW, Choi BS, Yang CW, Li C
- KMID: 2457031
- Korean J Intern Med.
- 2019 Sep;34(5):1078-1090.
- doi: 10.3904/kjim.2017.276
BACKGROUND/AIMS: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a... -
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- Increased CD68/TGFβ Co-expressing Microglia/Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys
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Yeo HG, Hong JJ, Lee Y, Yi KS, Jeon CY, Park J, Won J, Seo J, Ahn YJ, Kim K, Baek SH, Hwang EH, Kim G, Jin YB, Jeong KJ, Koo BS, Kang P, Lim KS, Kim SU, Huh JW, Kim YH, Son Y, Kim JS, Choi CH, Cha SH, Lee SR
- KMID: 2458544
- Exp Neurobiol.
- 2019 Aug;28(4):458-473.
- doi: 10.5607/en.2019.28.4.458
The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in... -
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- Preparation and Characterization of Human Adipose Tissue-Derived Extracellular Matrix, Growth Factors, and Stem Cells: A Concise Review
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Chun SY, Lim JO, Lee EH, Han MH, Ha YS, Lee JN, Kim BS, Park MJ, Yeo M, Jung B, Kwon TG
- KMID: 2455047
- Tissue Eng Regen Med.
- 2019 Aug;16(4):385-393.
- doi: 10.1007/s13770-019-00199-7
BACKGROUND: Human adipose tissue is routinely discarded as medical waste. However, this tissue may have valuable clinical applications since methods have been devised to effectively isolate adipose-derived extracellular matrix (ECM),... -
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- The Significance of NOTCH Pathway in the Development of Fibrosis in Systemic Sclerosis
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Zmorzyński S, Styk W, Filip AA, Krasowska
- KMID: 2451472
- Ann Dermatol.
- 2019 Aug;31(4):365-371.
- doi: 10.5021/ad.2019.31.4.365
Systemic sclerosis (SSc) is an autoimmune disorder characterized by the fibrosis of skin, heart, lung, and kidney as well. Excessive activation of fibroblasts is associated with higher expression of Notch1... -
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- Effect of Manuka Honey on Transforming Growth Factor Beta-1-Induced Extracelluar Matrix Production in Nasal Polyp Derived Fibroblasts
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Kil BK, Kim BM, Kang BJ, Ye MK, Shin SH
- KMID: 2451614
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Jun;62(6):336-342.
- doi: 10.3342/kjorl-hns.2018.00682
BACKGROUND AND OBJECTIVES: Manuka honey has anti-microbial, anti-inflammatory, and anti-proliferative action with a high concentration of methylglyoxal compound. It is also effective in killing Staphylococcus aureus biofilm and effective for... -
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- Conditioned Medium from Tonsil-Derived Mesenchymal Stem Cells Relieves CClâ‚„-Induced Liver Fibrosis in Mice
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Kim YH, Cho KA, Park M, Kim HS, Park JW, Woo SY, Ryu KH
- KMID: 2441255
- Tissue Eng Regen Med.
- 2019 Feb;16(1):51-58.
- doi: 10.1007/s13770-018-0160-8
BACKGROUND: The liver is an organ with remarkable regenerative capacity; however, once chronic fibrosis occurs, liver failure follows, with high mortality and morbidity rates. Continuous exposure to proinflammatory stimuli exaggerates... -
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- The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
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Lee SH, Shin JH, Shin MH, Kim YS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Park MS
- KMID: 2441729
- Tuberc Respir Dis.
- 2019 Jan;82(1):42-52.
- doi: 10.4046/trd.2017.0111
BACKGROUND: Transforming growth factor β (TGF-β), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect... -
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- Association Between Epithelial Cytokines and Clinical Phenotypes of Elderly Asthma
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Ulambayar , Lee SH, Yang EM, Ye YM, Park HS
- KMID: 2426787
- Allergy Asthma Immunol Res.
- 2019 Jan;11(1):79-89.
- doi: 10.4168/aair.2019.11.1.79
PURPOSE: Asthma in the elderly has different clinical features including more severe phenotypes with higher comorbidities. Epithelial cells are known to initiate innate/adaptive immune responses in asthmatic airways. We investigated... -
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- The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
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Lee HJ
- KMID: 2447447
- J Cancer Prev.
- 2018 Dec;23(4):162-169.
- doi: 10.15430/JCP.2018.23.4.162
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated... -
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- TGF-β1 upregulates the expression of hyaluronan synthase 2 and hyaluronan synthesis in culture models of equine articular chondrocytes
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Ongchai S, Somnoo O, Kongdang P, Peansukmanee S, Tangyuenyong S
- KMID: 2427021
- J Vet Sci.
- 2018 Nov;19(6):735-743.
- doi: 10.4142/jvs.2018.19.6.735
We investigated the effect of transforming growth factor beta 1 (TGF-β1) on equine hyaluronan synthase 2 (HAS2) gene expression and hyaluronan (HA) synthesis in culture models of articular chondrocytes. Equine... -
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- Recent Topics in Fibrodysplasia Ossificans Progressiva
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Katagiri T, Tsukamoto , Nakachi Y, Kuratani M
- KMID: 2447022
- Endocrinol Metab.
- 2018 Sep;33(3):331-338.
- doi: 10.3803/EnM.2018.33.3.331
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon. It... -
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- Development of an easy-to-handle murine model for the characterization of radiation-induced gross and molecular changes in skin
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Chang HP, Cho JH, Lee WJ, Roh H, Lee DW
- KMID: 2422135
- Arch Plast Surg.
- 2018 Sep;45(5):403-410.
- doi: 10.5999/aps.2018.00101
BACKGROUND: Radiation-induced skin injury is a dose-limiting complication of radiotherapy. To investigate this problem and to develop a framework for making decisions on treatment and dose prescription, a murine model... -
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- Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
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Peng J, Wang X, Ran L, Song J, Luo R, Wang Y
- KMID: 2421366
- J Breast Cancer.
- 2018 Sep;21(3):259-266.
- doi: 10.4048/jbc.2018.21.e42
PURPOSE: The transforming growth factor β1 (TGF-β1)/SMAD family member 3 (SMAD3) pathway, and hypoxia-inducible factor 1α (HIF-1α) are two key players in various types of malignancies including breast cancer. The... -
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- Detection of progressive and regressive phase and LINE-1 retrotransposon in transfected dogs with transmissible venereal tumor during chemotherapy
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Atalay Vural S, Haziroglu , Vural MR, Polat IM, Tunc AS
- KMID: 2420930
- J Vet Sci.
- 2018 Sep;19(5):620-626.
- doi: 10.4142/jvs.2018.19.5.620
Canine transmissible venereal tumor (CTVT) is a tumor that commonly occurs in genital and extragenital sites of both genders. Long interspersed nuclear elements (LINE-1) retrotransposon has a pivotal role in... -
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- TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation
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Albers RE, Selesniemi K, Natale DR, Brown TL
- KMID: 2413507
- Int J Stem Cells.
- 2018 Jun;11(1):111-120.
- doi: 10.15283/ijsc17069
BACKGROUND: Transforming growth factor beta (TGF-β) signaling has been shown to control a large number of critical cellular actions such as cell death, differentiation, and development and has been implicated... -
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- Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint
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van der Kraan PM
- KMID: 2413367
- J Bone Metab.
- 2018 May;25(2):65-72.
- doi: 10.11005/jbm.2018.25.2.65
Transforming growth factor-β (TGF-β) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role... -
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- The long non-coding RNA uc.4 influences cell differentiation through the TGF-beta signaling pathway
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Cheng Z, Zhang Q, Yin A, Feng M, Li H, Liu H, Li Y, Qian L
- KMID: 2440029
- Exp Mol Med.
- 2018 Feb;50(2):e447.
- doi: 10.1038/emm.2017.278
In a previous study, we screened thousands of long non-coding RNAs (lncRNAs) to assess their potential relationship with congenital heart disease (CHD). In this study, uc.4 attracted our attention because... -
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