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Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate

Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ

Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS...
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Analysis of the Clinical Characteristics of Cutaneous Malignant Tumors: 11-year Single-center Study in Daejeon City and Chungnam Province

Oh DY, Lee HK, Jung KE, Koo DW, Lee JS

  • KMID: 2465954
  • Korean J Dermatol.
  • 2019 Sep;57(8):464-475.
BACKGROUND: The occurrence of cutaneous malignant tumors has been increasing worldwide due to changes in various environmental factors. OBJECTIVE: Our study aimed to analyze the overall tendency of clinical characteristics in...
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Anti-melanogenesis and Anti-inflammatory Effects of Cinnamomi Cortex Extract In Vitro

Park JH, Park SJ, Park KY, Kim BJ

  • KMID: 2465952
  • Korean J Dermatol.
  • 2019 Sep;57(8):448-456.
BACKGROUND: Many researchers have sought to identify safe, natural herbal extracts that exert an anti-melanogenesis effect. Cinnamomi cortex has been widely used as a herbal medicine in Asia and Europe. OBJECTIVE:...
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No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

Wang JZ, Le S, Alexanian , Boddu S, Merleev A, Marusina A, Maverakis

PURPOSE: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene...
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A case of malignant melanoma after repeated recurrent dysplastic nevi

Jeong DK, Bae YC, Lee SJ, Kim HS, Choi YJ

Dysplastic nevus is common and affects about 10% of the northern European-descendent population. Studies over the past several decades have identified dysplastic nevi as a risk factor for malignant melanoma....
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Lichenoid Drug Eruption Developed in Melanoma Patient Treated with Nivolumab

Hong KR, Kwon R, Kim JE, Park YL, Lee SH

  • KMID: 2454380
  • Korean J Dermatol.
  • 2019 Jul;57(6):343-345.
No abstract available.
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A Case of Metastatic Malignant Melanoma Presenting as Subcutaneous Posterior Neck Mass

Lim SH, Koo BM, Kim MA, Kim SW

Malignant melanoma can be classified as both cutaneous and mucosal types. The former comprises more than 98% of all melanomas and is related to ultraviolet exposure, whereas the latter occupies...
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The first case of vaginal angiomatoid Spitz nevus causing vaginal bleeding

Park YH, Byun JM, Cho HJ, Jeong DH, Kim YN, Park HR, Lee KB, Sung MS

Angiomatoid Spitz nevus is a variant of melanocytic nevus with prominent vasculature. Due to its pathologic features, angiomatoid Spitz nevus in the vaginal wall is extremely rare. A 42-year-old woman...
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Effect of apoptosis on G361 cells by Cimicifuga rhizoma extract

Choi BB, Kim GC, Hong JW, Park SR

OBJECTIVES: To investigate whether the cytotoxic effect of Cimicifuga rhizoma extract is associated with cell death in the human keratinocyte (HaCaT) and human melanoma cell lines (G361). METHODS: Apoptosis induced by...
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Oncovascular Surgery: Essential Roles of Vascular Surgeons in Cancer Surgery

Han A, Ahn S, Min SK

For the modern practice of cancer surgery, the concept of oncovascular surgery (OVS), defined as cancer resection with concurrent ligation or reconstruction of a major vascular structure, can be very...
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A Case of Graphite Granuloma Mimicking Melanoma

Jeong GJ, Kim JM, Li K

  • KMID: 2451593
  • Korean J Dermatol.
  • 2019 Jun;57(5):281-282.
No abstract available.
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Induction of Melanoma Cell-Selective Apoptosis Using Anti-HER2 Antibody-Conjugated Gold Nanoparticles

Jeon HJ, Choi BB, Park KH, Hwang DS, Kim UK, Kim GC

PURPOSE: This study was conducted to verify the induction and mechanism of selective apoptosis in G361 melanoma cells using anti-HER2 antibody-conjugated gold nanoparticles (GNP-HER2). MATERIALS AND METHODS: Following GNP-HER2 treatment of...
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Analysis of Judicial Precedents Cases Regarding Skin Cancer from 1997 to 2017 in Republic of Korea

Shin SH, Lee W, Kim SY, Jo G, Mun JH, Cho SI

BACKGROUND: Both medical disputes and the incidence of skin cancer are increasing in Korea. OBJECTIVE: The aim of this study was to figure out the medical litigation related to skin cancer...
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Differential Gene Expression Common to Acquired and Intrinsic Resistance to BRAF Inhibitor Revealed by RNA-Seq Analysis

Ahn JH, Hwang SH, Cho HS, Lee M

Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P)...
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A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models

Heo JR, Hwang KA, Kim SU, Choi KC

PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into...
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Clinical Analysis of Benign and Malignant Nasal Septal Tumors

Lee DH, Lim SC, Yoon SH, Kang TG, Park JM

BACKGROUND AND OBJECTIVES: The purpose of this study was to review the clinical characteristics and treatment outcomes of benign and malignant nasal septal tumors. SUBJECTS AND METHODS: A total of 34...
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Anti-melanogenic effects of Hordeum vulgare L. barely sprout extract in murine B16F10 melanoma cells

Choi JH, Jung JG, Kim JE, Bang MA

PURPOSE: Barely sprout is a well-known oriental herbal medicine with a wide range of health benefits. Recent studies have provided scientific evidence of its therapeutic effects with expanded application. This...
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Clinicopathologic Features and Prognostic Factors of Primary Cutaneous Melanoma: a Multicenter Study in Korea

Kim JE, Chung BY, Sim CY, Park AY, Lee JS, Whang KU, Park YL, Kim HO, Park CW, Lee SY

BACKGROUND: Malignant melanoma is a cutaneous malignancy with a high mortality rate and high potential for metastases. Detailed information on the clinicopathologic characteristics and prognostic factors of cutaneous melanoma is...
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A Case of Corneal Dysplasia with Identification of POLH Gene Variants in Xeroderma Pigmentosum

Shin EH, Lim DH, Kim YD, Woo KI, Han J, Park JE, Chung TY, Ki CS

PURPOSE: To discuss the clinical course and diagnosis of corneal dysplasia in a xeroderma pigmentosum patient based on a genetic evaluation. CASE SUMMARY: A 42-year-old female visited our clinic for decreased...
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Primary Malignant Melanoma of the Breast: A Report of Two Cases

Koh J, Lee J, Jung SY, Kang HS, Yun T, Kwon Y

Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one derived from...
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