Korean J Dermatol.
2000 Sep;38(9):1205-1211.
Immunohistochemical Study of TGF- type I and type II receptor Expression in Psoriatic Epidermis
- Affiliations
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- 1Department of Dermatology, Inha University College of Medicine, Incheon, Korea.
Abstract
- BACKGROUND: Previous studies have demonstrated the pathogenetic role and expression of TGF-beta in psoriatic lesion. Transforming growth factor s are a family of growth factors with inhibitory effects on epithelial cell proliferation. Their effects are mediated by two interacting receptors, of which type I receptor mediates signal transduction after interaction with type II receptor carrying the TGF ligand. OBJECTIVE: The purpose of this study was to investigate the relationship between development of psoriasis and expression of TGF-beta receptors in psoriatic lesion. METHODS: We have studied the expression of TGF-beta type I and type II receptors in psoriatic lesions of 30 psoriatic patients who had not been treated for 1 month, 5 non-lesional psoriatic skin, and 3 normal human skin by immunohistochemical staining using polyclonal rabit antisera. RESULTS: 1. Immunohistochemical analysis revealed an intense immunoreactivity for TGF-beta type I and type II receptors in the basal and also suprabasal layer of normal epidermis and non-lesional psoriatic skin. 2. Almost all psoriatic lesions studied lacked detectable immunoreactivity of either receptor in the epidermis. CONCLUSION: We suggest the lack of TGF-beta - mediated growth inhibition by down regulation of TGF-beta receptor expression may play an important role in the pathogenesis of psoriasis.
MeSH Terms
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Down-Regulation
Epidermis*
Epithelial Cells
Humans
Immune Sera
Intercellular Signaling Peptides and Proteins
Psoriasis
Receptors, Transforming Growth Factor beta
Signal Transduction
Skin
Transforming Growth Factor beta
Transforming Growth Factors
Immune Sera
Intercellular Signaling Peptides and Proteins
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Transforming Growth Factors
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