Cancer Res Treat.  2004 Jun;36(3):199-204.

The Efficacy of a Modified Chronomodulated Infusion of Oxaliplatin, 5-Fluorouracil and Leucovorin in Advanced Colorectal Cancer (Preliminary Data)

• Park JY
• Kim SY
• Lee JJ
• Yoon HJ
• Cho KS

Abstract

PURPOSE
To determine the efficacy and tolerability of a modified chronomodulated infusion of oxaliplatin, 5-fluorouracil (5-FU) and leucovorin in the treatment of advanced colorectal cancer.
MATERIALS AND METHODS
Sixteen patients with relapsed or metastatic colorectal cancer were treated with an intravenous infusion of oxaliplatin 25 mg/m(2), 5-FU 700 mg/m(2) and leucovorin 20 mg/m(2) on days 1 to 5. The infusion of oxaliplatin was chronomodulated with a peak delivery rate at 16: 00 p.m., with 5-FU infused constantly overnight. Each course was repeated every 21 days.
RESULTS
The response rate was 38.5% (95% confidence interval [CI], 13.9% to 68.4%) in the 13 measurable patients, including 1 complete response (7.7%) and 4 partial responses (30.8%). Five patients (38.5%) had a stable disease and 3 (23.0%) a progressive disease. Three patients without a measurable lesion had improved status. The median time to progression and overall survival were 29 weeks and 85 weeks, respectively. Grade 3 thrombocytopenia occurred in 2.5% (2 cycles) and grade 3 vomiting in 12.5% (2 patients). Anorexia, stomatitis, diarrhea, pruritus, alopecia and peripheral neuropathy were mild and tolerable.
CONCLUSION
The modified chronomodulated infusion of oxaliplatin, 5-FU and leucovorin is effective and tolerable, but the number of patients was too small. Further study will be needed to confirm the efficacy of this regimen with a larger population of patients.

Keyword

Colorectal neoplasm; Chemotherapy; Chronotherapy; Oxaliplatin; 5-fluorouracil; Leucovorin

MeSH Terms

Alopecia
Anorexia
Chronotherapy
Colorectal Neoplasms*
Diarrhea
Drug Therapy
Fluorouracil*
Humans
Infusions, Intravenous
Leucovorin*
Peripheral Nervous System Diseases
Pruritus
Stomatitis
Thrombocytopenia
Vomiting
Fluorouracil
Leucovorin

Figure

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  Fig. 1 Therapeutic plan.

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  Fig. 2 Time to progression.

• 

  Fig. 3 Overall survival.

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