Korean J Med.  2006 Jul;71(1):86-90.

Diffuse alveolar damage during chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. chepraxis@korea.com
  • 2Department of Pathology, College of Medicine, Korea University, Seoul, Korea.

Abstract

The combination chemotherapy of oxaliplatin with 5-fluorouracil and leucovorin (FOLFOX regimen) has been recently proved to be beneficial in advanced colorectal and gastric cancer. Side effects of this regimen include neutropenia, diarrhea, and neurosensory toxicity. However, the case reports about pulmonary toxicities of this regimen are very limited. Herein is the reported case of a patient treated with oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in whom diffuse alveolar damage developed and the disease improved after steroid pulse therapy.

Keyword

Oxaliplatin; Fluorouracil; Leucovorin; Drug toxicity; Interstitial lung disease

MeSH Terms

Diarrhea
Drug Therapy*
Drug Therapy, Combination
Drug-Related Side Effects and Adverse Reactions
Fluorouracil*
Humans
Leucovorin*
Lung Diseases, Interstitial
Neutropenia
Stomach Neoplasms
Fluorouracil
Leucovorin
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