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Successful Treatment of Isolated Central Nervous System Relapse with Intrathecal Chemotherapy in an Adolescent with Acute Promyelocytic Leukemia

Song H, Yi ES

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by translocation of chromosomes 15 and 17 (t(15;17)), which rarely occurs in the pediatric population. Isolated central...
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Multimodal Treatment of Sarcomas Linked to BCOR-CCNB3 Fusion in Pediatrics: A 3-Patient Case Series

Omar S, Albritton K, Heym K, Wang J, Ray A

In 2012, a new neoplasm was classified according to fusion of the B-cell lymphoma (BCL-6) corepressor (BCOR) gene and the testis-specific cyclin B3 (CCNB3) gene on the X-chromosome, known as...
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Lumboperitoneal Shunt Combined With Ommaya Reservoir Enables Continued Intraventricular Chemotherapy for Leptomeningeal Metastasis With Increased Intracranial Pressure

Woo B, Gwak HS, Kwon JW, Shin SH, Yoo H

Background Intra-cerebrospinal fluid (CSF) chemotherapy for leptomeningeal metastasis (LM) can be delivered intraventricularly via an Ommaya reservoir. However, hydrocephalus associated with LM can interfere with chemotherapeutic drug distribution, and ventriculoperitoneal...
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Medical Treatment of Pediatric Low-Grade Glioma

Lim YJ

Low-grade glioma (LGG) is the most common brain tumor in children and has excellent long-term survival. With an excellent survival rate, the choice of treatment involves careful consideration of minimizing...
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Neoadjuvant Immunotherapy Following Definitive Surgical Treatment for Locoregionally Advanced Head and Neck Cancer: Perioperative Complication and Surgical Outcomes

Park JH, Park YM, Kim DH, Kim SH, Kim HR, Koh YW

Background and Objectives We analyzed surgical outcomes, perioperative complications, and mortality in head and neck squamous cell carcinoma (HNSCC) in patients who underwent curative surgery following neoadjuvant immunotherapy. Subjects and Method...
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Clinical Evidence of Chemotherapy or Endocrine Therapy Maintenance in Patients with Metastatic Breast Cancer: Meta-Analysis of Randomized Clinical Trials and Propensity Score Matching of Multicenter Cohort Study

Ren W, Yu Y, Hong H, Wang Y, Gao Q, Chen Y, Chen P, Zhao J, Ou Q, Lin D, Fu T, Tan Y, Li C, Xie X, Ye G, Tang J, Yao H

Purpose This study aims to comprehensively evaluate the clinical efficacy of chemotherapy or endocrine therapy maintenance in metastatic breast cancer (MBC) patients. Materials and Methods The meta-analysis of randomized clinical trials...
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Predictive Parameters of Febrile Neutropenia and Clinical Significance of G-CSF Receptor Signaling Pathway in the Development of Neutropenia during R-CHOP Chemotherapy with Prophylactic Pegfilgrastim in Patients with Diffuse Large B-Cell Lymphoma

Kim DY, Nam J, Chung JS, Jeon BE, Lee JH, Jo JC, Kim SW, Shin HJ

Purpose Pegfilgrastim is widely used to prevent chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) in patients with diffuse large B-cell lymphoma (DLBCL). We investigated the predictive factors affecting CIN and...
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The Role of Neutrophil-to-Lymphocyte Ratio in Predicting Pathological Response for Resectable Non–Small Cell Lung Cancer Treated with Neoadjuvant Chemotherapy Combined with PD-1 Checkpoint Inhibitors

Sun X, Feng Y, Zhang B, Huang W, Zhao X, Zhang H, Yue D, Wang C

Purpose The aim of our study was to investigate the value of baseline and preoperative neutrophil-to-lymphocyte ratio (NLR) in predicting the pathological response and disease-free survival (DFS) of neoadjuvant chemotherapy alone...
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Adjuvant Imatinib Treatment for 5 Years versus 3 Years in Patients with Ruptured Localized Gastrointestinal Stromal Tumor: A Retrospective Analysis

Kang S, Ryu MH, Bang YH, Kim HD, Lee HE, Kang YK

Purpose Three years of adjuvant imatinib is the standard treatment for resected gastrointestinal stromal tumors (GISTs) with rupture, but the recurrence rate is prominently high. We aimed to investigate the...
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Effect of Ambulatory Chemotherapy (Portable Infusion Pump Use) Video Education on Knowledge, Self-efficacy and Anxiety of Colorectal Cancer Patients

Choi EH, Park EY, Park YA, Son YH, Jang MJ

Purpose: The purpose of this study is to identify changes in knowledge, self-efficacy and anxiety achieved through the provision of video education on chemotherapy with a portable infusion pump to...
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Factors Associated with Chemotherapy-induced Neutropenia in Diffuse Large B-cell Lymphoma Patients Undergoing Combination Chemotherapy: A Case-Control Study

Lim SY, Choi JY

Purpose: This study aimed to identify the factors associated with chemotherapy-induced neutropenia (CIN) in diffuse large B-cell lymphoma (DLBCL) patients undergoing combination chemotherapy. Methods: A total of 111 patients with...
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Symptom Experience and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy

Lee A, Park JH

Purpose: This study aimed to evaluate symptom experience and quality of life (QoL) and to identify the predictors of QoL among colorectal cancer patients undergoing chemotherapy. Methods: A cross-sectional study...
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The effect of a support program on the burden of spouses caring for their partners with breast cancer: a randomized controlled trial

Hosseinnejad SZ, Elyasi F, Mousavinasab SN, Shahhosseini Z

Objective This study aimed to determine the effect of a support program on burden of spouses caring for their partners with breast cancer. Methods This randomized controlled trial was conducted among spouses of...
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Treatment outcomes of high-dose chemotherapy plus stem cell rescue in high-risk neuroblastoma patients in Thailand

Suwannaying K, Techavichit P, Komvilaisak P, Laoaroon N, Narkbunnam N, Sanpakit K, Chiengthong K, Chotsampancharoen T, Sathitsamitphong L, Santong C, Seksarn P, Hongeng S, Wiangnon S

Background: In 2013, the Thai Pediatric Oncology Group (ThaiPOG) introduced a national protocol in which high-dose chemotherapy plus stem cell rescue is performed without immunotherapy. Methods: This study aimed to elucidate...
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A Case of Combination Therapy of IFN-β1b and Mitomycin-C on Recurred Ocular Surface Squamous Neoplasia

Lee JK, Son BK, Jin KH

Purpose: To report a case of combination therapy with interferon β1b (IFN-β1b) and mitomycin-C (MMC) for recurrent ocular surface squamous neoplasia (OSSN). Case summary: A 72-year-old female presented with a white...
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Neoadjuvant and Adjuvant Chemotherapy for Cholangiocarcinoma

Lee HS

Cholangiocarcinoma consists of a heterogeneous group of aggressive and rare malignancies that arise from the bile ducts outside or inside the liver. Although surgical resection remains the only potential curative...
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Managing Side Effects of Cytotoxic Chemotherapy in Patients With High Grade Gliomas

Ha H, Lim JH

Cytotoxic chemotherapy has been a mainstay of cancer treatment since the 1940s. In the recent era of emergent targeted therapies and immunotherapies, many cytotoxic chemotherapy agents including temozolomide are still...
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Local Drug Delivery Strategies for Glioblastoma Treatment

Cha GD, Jung S, Choi SH, Kim DH

Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason for the limited efficacy of standard treatment is the high recurrence rate of GBM, even after...
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Postoperative quality of life after gastrectomy in gastric cancer patients: a prospective longitudinal observation study

Wang CJ, Suh YS, Lee HJ, Park JH, Park SH, Choi JH, Alzahrani F, Alzahrani K, Kong SH, Park DJ, Cao H, Yang HK

Purpose: The European Organization for Research and Treatment of Cancer quality of life (QOL) questionnaires (QLQ-C30, QLQ-OG25, and QLQ-STO22) are widely used for the assessment of gastric cancer patients. This...
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Management of inoperable endometrial cancer

Pitakkarnkul S, Chanpanitkitchot S, Tangjitgamol S

Some endometrial cancer (EMC) patients are not good candidates for primary surgery. The three major types of treatment for inoperable EMC are radiation therapy, chemotherapy, or their combination as neoadjuvant...
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