- Enzymes involved in folate metabolism and its implication for cancer treatment
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Kim SE
- KMID: 2471876
- Nutr Res Pract.
- 2020 Apr;14(2):95-101.
- doi: 10.4162/nrp.2020.14.2.95
BACKGROUND/OBJECTIVES: Folate plays a critical role in DNA synthesis and methylation. Intracellular folate homeostasis is maintained by the enzymes folylpolyglutamate synthase (FPGS) and γ-glutamyl hydrolase (GGH). FPGS adds glutamate residues... -
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- The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy
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Hu L, Bai Z, Ma X, Bai N, Zhang Z
- KMID: 2471929
- J Gastric Cancer.
- 2020 Mar;20(1):95-105.
- doi: 10.5230/jgc.2020.20.e9
PURPOSE: Gastric cancer is a highly metastatic malignant tumor, often characterized by chemoresistance and high mortality. In the present study, we aimed to investigate the role of B-cell lymphoma 3... -
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- Two Cases of Unresectable Pancreatic Cancer Treated with Neoadjuvant Chemotherapy and Surgical Resection
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Huh G, Chun JW, You MS, Paik WH, Lee SH, Kim YT, Ryu JK
- KMID: 2470444
- J Dig Cancer Res.
- 2019 Dec;7(2):61-64.
- doi: 10.0000/jdcr.2019.7.2.61
We report two cases of patients with unresectable pancreatic cancer treated with neoadjuvant chemotherapy and surgical resection. In the first case, main mass was located at the neck of the... -
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- Correlation between Carotid Arterial Calcium Score and Silent Cerebrovascular Lesions in Obstructive Sleep Apnea Patients: by Using Upper Airway CT and Brain MRI
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Kim MS, Kang EJ, Bae WY, Kim JK, Kim CH, Choi JH, Kim SH, Kim DY, Lee KN
- KMID: 2464918
- J Korean Soc Radiol.
- 2019 Nov;80(6):1214-1228.
- doi: 10.3348/jksr.2019.80.6.1214
PURPOSE: To investigate the relationship between carotid arterial calcium score (CarACS) and silent cerebrovascular lesions in patients with obstructive sleep apnea (OSA). MATERIALS AND METHODS: This study involved retrospective evaluation of... -
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- A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models
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Heo JR, Hwang KA, Kim SU, Choi KC
- KMID: 2464425
- Cancer Res Treat.
- 2019 Apr;51(2):797-811.
- doi: 10.4143/crt.2018.364
PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into... -
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- Preclinical Efficacy of [Vâ´Qâµ]dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer
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Garona J, Sobol NT, Pifano M, Segatori V, Gomez DE, Ripoll GV, Alonso DF
- KMID: 2464391
- Cancer Res Treat.
- 2019 Apr;51(2):438-450.
- doi: 10.4143/crt.2018.040
PURPOSE: Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4 Q5 ]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma... -
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- Carotid Arterial Calcium Scoring Using Upper Airway Computed Tomography in Patients with Obstructive Sleep Apnea: Efficacy as a Clinical Predictor of Cerebrocardiovascular Disease
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Lee JH, Kang EJ, Bae WY, Kim JK, Choi JH, Kim CH, Kim SJ, Jo KS, Kim MS, Koh TK
- KMID: 2440486
- Korean J Radiol.
- 2019 Apr;20(4):631-640.
- doi: 10.3348/kjr.2018.0550
OBJECTIVE: To evaluate the value of airway computed tomography (CT) in patients with obstructive sleep apnea (OSA) as a predictor of cerebrocardiovascular disease (CCVD) clinically, by quantitatively analyzing carotid arterial... -
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- High-dose versus Low-dose 5-Fluorouracil and Cisplatin Based Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma
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Lim CJ, Hong JY, Ko YS, Chung MW, Jun CH, Choi SK, Cho SB
- KMID: 2448275
- J Liver Cancer.
- 2019 Mar;19(1):38-45.
- doi: 10.17998/jlc.19.1.38
BACKGROUND/AIMS: Hepatic arterial infusion chemotherapy (HAIC) has been reported as an effective treatment for advanced hepatocellular carcinoma. The aim of this study is to compare the effect and safety between... -
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- Postoperative Chemoradiotherapy for R1 Resected Intrahepatic Cholangiocarcinoma
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Kim KS, Kim HY, Kim K, Yi NJ, Suh KS, Chie EK
- KMID: 2422623
- J Liver Cancer.
- 2018 Sep;18(2):115-120.
- doi: 10.17998/jlc.18.2.115
BACKGROUND/AIMS: To investigative the potential role of postoperative chemoradiotherapy (CCRT) after R1 resection of intrahepatic cholangiocarcinoma (IHCC). METHODS: Between January 2000 and December 2012, medical records of 18 patients who underwent... -
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- Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer
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Kang J, Park JS, Ahn SG, Lim JH, Baik SH, Yoon DS, Lee KY, Jeong J
- KMID: 2419447
- Ann Surg Treat Res.
- 2018 Sep;95(3):161-167.
- doi: 10.4174/astr.2018.95.3.161
PURPOSE: This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer. METHODS: This retrospective study... -
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- Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells
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Hong R, Han SI
- KMID: 2419001
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):513-523.
- doi: 10.4196/kjpp.2018.22.5.513
The tumor microenvironment greatly influences cancer cell characteristics, and acidic extracellular pH has been implicated as an essential factor in tumor malignancy and the induction of drug resistance. Here, we... -
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- Acute Aortic Thrombosis Following Capecitabine Chemotherapy in a Patient with Colon Cancer
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Lee MK, Kim EY, Kim YS, Sym SJ, Kim JH
- KMID: 2418658
- J Korean Soc Radiol.
- 2018 Sep;79(3):166-170.
- doi: 10.3348/jksr.2018.79.3.166
The elevated risk for thromboembolic events in cancer patients has been well documented. Chemotherapy is considered to be one of the most important risk factors for cardiovascular complications such as... -
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- Hepatoid Carcinoma of the Pancreas Presenting as Acute Pancreatitis
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Shin SW, Sung YN, So H, Song E, Oh CR, Hong SM, Park DH
- KMID: 2435076
- Korean J Med.
- 2018 Aug;93(4):387-392.
- doi: 10.3904/kjm.2018.93.4.387
Hepatoid carcinoma is extrahepatic neoplasm showing similar morphologic, immunohistochemical features with hepatocellular carcinoma. It's a very rare disease and has been reported most frequently in the stomach. Herein, we report... -
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- Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance
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Li Z, Chan K, Qi Y, Lu L, Ning F, Wu M, Wang H, Wang Y, Cai S, Du J
- KMID: 2417878
- Cancer Res Treat.
- 2018 Jul;50(3):894-907.
- doi: 10.4143/crt.2017.356
PURPOSE: Cancer-associated fibroblasts (CAFs) activated by cancer cells has a central role in development and malignant biological behavior in colorectal cancer (CRC). Adult fibroblasts do not express Snail, but Snail-positive... -
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- Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway
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Lee JH, Yun CW, Lee SH
- KMID: 2421741
- Biomol Ther.
- 2018 May;26(3):313-321.
- doi: 10.4062/biomolther.2017.033
Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive.... -
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- Hepatic Arterial Infusion Chemotherapy Using the Port System in Advanced Gallbladder Cancer
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Eun JR, Kim JW, Choi JH
- KMID: 2435035
- Korean J Med.
- 2018 Feb;93(1):50-54.
- doi: 10.3904/kjm.2018.93.1.50
Gallbladder (GB) cancer is relatively rare and has a poor prognosis, with a median survival time of less than 3 months. It is resistant to chemotherapy. Therefore, the role of... -
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- S-1–Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study
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Kim N, Kim JW, Baek JH, Kim JS, Choung HK, Kim TY, Lee KH, Bang YJ, Khwarg SI, Ahn SH, Park DJ, Kim HH, Chung JY, Ahn S, Lee KW
- KMID: 2403472
- Cancer Res Treat.
- 2018 Jan;50(1):30-39.
- doi: 10.4143/crt.2016.569
PURPOSE: This prospective study was conducted to determine the incidence of lacrimal drainage obstruction (LDO) during S-1 chemotherapy and evaluate the association between the development of LDO and the concentrations... -
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- Comparison of Effects and Complications between Conventional Trabeculectomy and Trabeculectomy with a Collagen Matrix Insertion
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Park KS, Kim KN, Lee SB, Kim JY, Kim CS
- KMID: 2401678
- J Korean Ophthalmol Soc.
- 2018 Jan;59(1):50-59.
- doi: 10.3341/jkos.2018.59.1.50
PURPOSE: To compare the surgical outcomes between trabeculectomy with a collagen matrix (Ologen®) insertion and conventional trabeculectomy. METHODS: An ophthalmic examination, including tonometry and a slit lamp examination, was performed 1... -
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- Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI
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Durot C, Dohan A, Boudiaf M, Servois V, Soyer P, Hoeffel C
- KMID: 2427204
- Korean J Radiol.
- 2017 Dec;18(6):946-956.
- doi: 10.3348/kjr.2017.18.6.946
Although a rare disease, anal cancer is increasingly being diagnosed in patients with risk factors, mainly anal infection with the human papilloma virus. Magnetic resonance imaging (MRI) with external phased-array... -
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- The outcomes of intensified 5-fluorouracil plus leucovorin chemotherapy for preoperative chemoradiation in rectal cancers
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Ha N, Hong KD, Ji WB, Kim JS, Um JW
- KMID: 2405657
- Korean J Clin Oncol.
- 2017 Dec;13(2):147-151.
- doi: 10.14216/kjco.17023
PURPOSE: The clinical benefit of intensified neoadjuvant chemoradiotherapy (CRT) in rectal cancer has not been proved. We investigated clinical outcomes of intensified 5-fluorouracil plus leucovorin (5-FU/LV) chemotherapy. METHODS: We retrospectively analyzed... -
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