Exp Neurobiol.  2010 Jun;19(1):30-38. 10.5607/en.2010.19.1.30.

Antidepressant-like Effect of Kaempferol and Quercitirin, Isolated from Opuntia ficus-indica var. saboten

Affiliations
  • 1Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Korea. hwsuh@hallym.ac.kr
  • 2Department of Neuroscience and Medical Research Institute, Ewha Womans University School of Medicine, Seoul 110-783, Korea.

Abstract

Opuntia ficus-indica var. saboten. is widely cultivated in Jeju Island (South Korea) for use in manufacture of health foods. This study described antidepressant effect of two flavonoids (kaempferol and quercitrin) isolated from the Opuntia ficus-indica var. saboten. The expression of the hypothalamic POMC mRNA or plasma beta-endorphin levels were increased by extract of Opintia ficus-indica var. saboten or its flavoniods administered orally. In addition, antidepressant activity was studied using tail suspension test (TST), forced swimming test (FST) and rota-rod test in chronically restraint immobilization stress group in mice. After restraint stress (2 hrs/day for 14 days), animals were kept in cage for 14 days without any further stress, bet with drugs. Mice were fed with a diet supplemented for 14 days and during the behavioral test period with kaempferol or quercitrin (30 mg/kg/day). POMC mRNA or plasma beta-endorphin level was increased by extract of Opintia ficus-indica var. saboten and its flavoniods. In addition, immobility time in TST and FST was significantly reduced by kaempferol or quercitrin. In rota-rod test, the time of permanence was maintained to the semblance of control group in turning at 15 rpm. Our results suggest that two flavonoids (kaempferol and quercitrin) isolated from the Opuntia ficus-indica var. saboten. show a potent antidepressant effect.

Keyword

kaempferol; quercitirin; antidepressant; Opuntia ficus-indica var. saboten

MeSH Terms

Animals
beta-Endorphin
Diet
Flavonoids
Hindlimb Suspension
Immobilization
Kaempferols
Mice
Opuntia
Plasma
Pro-Opiomelanocortin
Quercetin
RNA, Messenger
Swimming
Food, Organic
Flavonoids
Kaempferols
Pro-Opiomelanocortin
Quercetin
RNA, Messenger
beta-Endorphin
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