- A Group of Descending Glutamatergic Neurons Activated by Stress in Corticolimbic Regions Project to the Nucleus Accumbens
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Park JY, Park SY, Kwon H, Song Y, Yun B, Lee Y, Cho Y, Joo A, Han PL
- KMID: 2424733
- Exp Neurobiol.
- 2018 Oct;27(5):387-396.
- doi: 10.5607/en.2018.27.5.387
The nucleus accumbens (NAc) is the major component of the ventral striatum that regulates stress-induced depression. The NAc receives dopaminergic inputs from the ventral tegmental area (VTA), and the role... -
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- Experimental Neurobiology: The Past, Present, and Future
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Oh YJ, Han PL, Lee CJ
- KMID: 2458542
- Exp Neurobiol.
- 2019 Aug;28(4):447-450.
- doi: 10.5607/en.2019.28.4.447
No abstract available. -
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- Rapid Disruption of Cellular Integrity of Zinc-treated Astroglia Is Regulated by p38 MAPK and Ca(2+)-dependent Mechanisms
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Im JY, Joo HJ, Han PL
- KMID: 2165345
- Exp Neurobiol.
- 2011 Mar;20(1):45-53.
- doi: 10.5607/en.2011.20.1.45
Cultured cortical primary astroglia treated with zinc died while rapidly detached from culture plates, a distinct part of zinc-treated astroglia. In the present study, we investigated the mechanism underlying the... -
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- Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits
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Choi J, Kwon HJ, Seoh JY, Han PL
- KMID: 2524038
- Exp Neurobiol.
- 2021 Dec;30(6):415-429.
- doi: 10.5607/en21029
Hyperoxygenation therapy remediates neuronal injury and improves cognitive function in various animal models. In the present study, the optimal conditions for hyperoxygenation treatment of stress-induced maladaptive changes were investigated. Mice... -
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- Hyperoxygenation Treatment Reduces Beta-amyloid Deposition via MeCP2-dependent Upregulation of MMP-2 and MMP-9 in the Hippocampus of Tg-APP/PS1 Mice
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Choi J, Kwon H, Han PL
- KMID: 2519891
- Exp Neurobiol.
- 2021 Aug;30(4):294-307.
- doi: 10.5607/en21014
Recently we reported that hyperoxygenation treatment reduces amyloid-beta accumulation and rescues cognitive impairment in the Tg-APP/PS1 mouse model of Alzheimer’s disease. In the present study, we continue to investigate the... -
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- Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells
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Han HE, Kim TK, Son HJ, Park WJ, Han PL
- KMID: 2170681
- Biomol Ther.
- 2013 Jan;21(1):21-28.
Microglia play a role in maintaining and resolving brain tissue homeostasis. In pathological conditions, microglia release pro-inflammatory cytokines and cytotoxic factors, which aggravate the progression of neurodegenerative diseases. Autophagy pathway... -
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- Chronic Antidepressant Treatment in Normal Mice Induces Anxiety and Impairs Stress-coping Ability
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Baek IS, Park JY, Han PL
- KMID: 2165550
- Exp Neurobiol.
- 2015 Jun;24(2):156-168.
- doi: 10.5607/en.2015.24.2.156
Antidepressants are clinically used for patients with major depression. Antidepressant treatments in certain groups of patients are effective for relieving depression as well as anxiety disorder. However, it is not... -
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- Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
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Seo JS, Choi J, Leem YH, Han PL
- KMID: 2165569
- Exp Neurobiol.
- 2015 Dec;24(4):341-350.
- doi: 10.5607/en.2015.24.4.341
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord, resulting in paralysis of voluntary skeletal muscles and eventually death, usually within... -
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- Striatal Inhibition of MeCP2 or TSC1 Produces Sociability Deficits and Repetitive Behaviors
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Lee Y, Kim H, Han PL
- KMID: 2430110
- Exp Neurobiol.
- 2018 Dec;27(6):539-549.
- doi: 10.5607/en.2018.27.6.539
Autism spectrum disorder (ASD) is a heterogeneous group of neurobehavioral disorders characterized by the two core domains of behavioral deficits, including sociability deficits and stereotyped repetitive behaviors. It is not... -
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- Reversal of an Unconditioned Behavioral Preference for Specific Food Pellets by Intervention of Whisker Sensory Inputs
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Kim H, Lee Y, Kim JE, Han PL
- KMID: 2352877
- Exp Neurobiol.
- 2016 Apr;25(2):79-85.
- doi: 10.5607/en.2016.25.2.79
Adenylyl cyclase type-5 (AC5) is preferentially expressed in the dorsal striatum. Recently, we reported that AC5 knockout (KO) mice preferred food pellets carrying an olfactory cue produced by AC5 KO... -
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- Repeated Short-term (2hx14d) Emotional Stress Induces Lasting Depression-like Behavior in Mice
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Kim KS, Kwon HJ, Baek IS, Han PL
- KMID: 2165386
- Exp Neurobiol.
- 2012 Mar;21(1):16-22.
- doi: 10.5607/en.2012.21.1.16
Chronic behavioral stress is a risk factor for depression. To understand chronic stress effects and the mechanism underlying stress-induced emotional changes, various animals model have been developed. We recently reported... -
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- Implementation of a Two-dimensional Behavior Matrix to Distinguish Individuals with Differential Depression States in a Rodent Model of Depression
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Park JY, Kim TK, Choi J, Lee JE, Kim H, Lee EH, Han PL
- KMID: 2165525
- Exp Neurobiol.
- 2014 Sep;23(3):215-223.
- doi: 10.5607/en.2014.23.3.215
Animal models of depression are used to study pathophysiology of depression and to advance therapeutic strategies. Stress-induced depression models in rodents are widely used. However, amenable behavioral criteria and experimental... -
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- AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease
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Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL
- KMID: 2165439
- Exp Neurobiol.
- 2013 Mar;22(1):31-37.
- doi: 10.5607/en.2013.22.1.31
Alzheimer's disease (AD) is a neurodegenerative disease that proceeds with the age-dependent neuronal loss, an irreversible event which causes severe cognitive and psychiatric devastations. In the present study, we investigated... -
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- Physiological Parameters in the Blood of a Murine Stress-Induced Depression Model before and after Repeated Passive Exercise
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Kim TK, Park JY, Han PL
- KMID: 2407089
- Endocrinol Metab.
- 2015 Sep;30(3):371-380.
- doi: 10.3803/EnM.2015.30.3.371
BACKGROUND: Animal models are necessary to study the mechanism underlying the effects of exercise on depression but an effective procedure for exercise treatment and exercise effects on physiological parameters in... -
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- An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions
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Lee JE, Han PL
- KMID: 1427106
- Exp Neurobiol.
- 2013 Jun;22(2):84-95.
- doi: 10.5607/en.2013.22.2.84
Animal models of Alzheimer disease (AD) are used to study the mechanisms underlying AD pathogenesis, genetic interactions with genes of interest, and environmental risk factors that cause sporadic AD as... -
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- Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors
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Kim TK, Han PL
- KMID: 2349689
- Exp Neurobiol.
- 2016 Aug;25(4):163-173.
- doi: 10.5607/en.2016.25.4.163
Chronic stress induces anxiety disorders, whereas physical exercise is believed to help people with clinical anxiety. In the present study, we investigated the mechanisms underlying stress-induced anxiety and its counteraction... -
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- Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Abeta pathology and improves cognitive function
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Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL
- KMID: 1402318
- Exp Mol Med.
- 2012 Dec;44(12):740-748.
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the... -
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- Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice
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Choi J, Kim YK, Han PL
- KMID: 2450211
- Exp Neurobiol.
- 2019 Apr;28(2):158-171.
- doi: 10.5607/en.2019.28.2.158
Gut microbiota play a role in regulating mental disorders, but the mechanism by which gut microbiota regulate brain function remains unclear. Gram negative and positive gut bacteria release membrane-derived extracellular... -
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- Antidepressant-like Effect of Kaempferol and Quercitirin, Isolated from Opuntia ficus-indica var. saboten
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Park SH, Sim YB, Han PL, Lee JK, Suh HW
- KMID: 2165317
- Exp Neurobiol.
- 2010 Jun;19(1):30-38.
- doi: 10.5607/en.2010.19.1.30
Opuntia ficus-indica var. saboten. is widely cultivated in Jeju Island (South Korea) for use in manufacture of health foods. This study described antidepressant effect of two flavonoids (kaempferol and quercitrin)... -
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- Immunohistochemical Localization of Translationally Controlled Tumor Protein in Axon Terminals of Mouse Hippocampal Neurons
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Bae SY, Sheverdin , Maeng J, Lyoo IK, Han PL, Lee K
- KMID: 2376575
- Exp Neurobiol.
- 2017 Apr;26(2):82-89.
- doi: 10.5607/en.2017.26.2.82
Translationally controlled tumor protein (TCTP) is a cytosolic protein with microtubule stabilization and calcium-binding activities. TCTP is expressed in most organs including the nervous system. However, detailed distribution and functional... -
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