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Kaempferol Regulates the Expression of Airway MUC5AC Mucin Gene via IκBα-NF-κB p65 and p38-p44/42-Sp1 Signaling Pathways

Li X, Jin F, Lee HJ, Lee CJ

In the present study, kaempferol, a flavonoidal natural compound found in Polygonati Rhizoma, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. A...
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The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate

Chae JB, Choi HR, Shin JW, Na JI, Huh CH, Park KC

BACKGROUND: Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a flavonoid known to have a wide range of pharmacological activities. The 3-OH group in flavonoids has been reported to determine antioxidant activities. OBJECTIVE: We tested whether...
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Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells

Lee GA, Choi KC, Hwang KA

Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3′-diindolylmethane (DIM) are phytoestrogens that play...
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Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol

Balli U, Cetinkaya , Keles GC, Keles ZP, Guler S, Sogut MU, Erisgin Z

PURPOSE: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the...
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Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization

An M, Kim M

Kaempferol exerts cardioprotective actions through incompletely understood mechanisms. This study investigated the molecular mechanisms underlying the cardioprotective effects of kaempferol in sinus node dysfunction (SND) heart. Here, we demonstrate that...
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Anti-cancer Effect and Underlying Mechanism(s) of Kaempferol, a Phytoestrogen, on the Regulation of Apoptosis in Diverse Cancer Cell Models

Kim SH, Choi KC

  • KMID: 2317840
  • Toxicol Res.
  • 2013 Dec;29(4):229-234.
Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long times, phytoestrogens have been used for therapeutic treatments against human diseases, and they can be promising ingredients...
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Antidepressant-like Effect of Kaempferol and Quercitirin, Isolated from Opuntia ficus-indica var. saboten

Park SH, Sim YB, Han PL, Lee JK, Suh HW

Opuntia ficus-indica var. saboten. is widely cultivated in Jeju Island (South Korea) for use in manufacture of health foods. This study described antidepressant effect of two flavonoids (kaempferol and quercitrin)...
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Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells

Choi EJ, Ahn WS

The aim of present study was to investigate the effects of kaempferol on cellular proliferation and cell cycle arrest and explore the mechanism for these effects in human breast carcinoma...
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Transcriptional profiling in human HaCaT keratinocytes in response to kaempferol and identification of potential transcription factors for regulating differential gene expression

Kang BY, Kim S, Lee KH, Lee YS, Hong I, Lee MO, Min D, Chang I, Hwang JS, Park JS, Kim DH, Kim BG

Kaempferol is the major flavonol in green tea and exhibits many biomedically useful properties such as antioxidative, cytoprotective and anti-apoptotic activities. To elucidate its effects on the skin, we investigated...
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Protective Effect of Flavonoids on Lymphocyte DNA Damage Using Comet Assay

Park YK, Jeon EJ, Kang MH

  • KMID: 2269636
  • Korean J Nutr.
  • 2003 Mar;36(2):125-132.
The present study was attempted to investigate and compare the antioxidant potency of several well-know flavonoids, antioxidant vitamin and commercially available popular beverages. The antioxidant potency was assessed by the...
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