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Effect of pertussis toxin pretreated centrally on blood glucose level induced by stress

Suh HW, Sim YB, Park SH, Sharma N, Im HJ, Hong JS

In the present study, we examined the effect of pertussis toxin (PTX) administered centrally in a variety of stress-induced blood glucose level. Mice were exposed to stress after the pretreatment...
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Effect of D-glucose feeding on mortality induced by sepsis

Kim SS, Sim YB, Park SH, Lee JR, Sharma N, Suh HW

Sepsis is the life-threatening response to infection which can lead to tissue damage, organ failure, and death. In the current study, the effect of orally administered D-glucose on the mortality...
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Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model

Sharma N, Sim YB, Park SH, Lim SM, Kim SS, Jung JS, Hong JS, Suh HW

Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice...
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The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Sim YB, Park SH, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW

The possible roles of spinal histamine receptors in the regulation of the blood glucose level were studied in ICR mice. Mice were intrathecally (i.t.) treated with histamine 1 (H1) receptor...
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Repaglinide, but Not Nateglinide Administered Supraspinally and Spinally Exerts an Anti-Diabetic Action in D-Glucose Fed and Streptozotocin-Treated Mouse Models

Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW

We have recently demonstrated that some anti-diabetic drugs such as biguanide and thizolidinediones administered centrally modulate the blood glucose level, suggesting that orally administered anti-diabetic drugs may modulate the blood...
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Effect of Cholera Toxin Administered Supraspinally or Spinally on the Blood Glucose Level in Pain and D-Glucose Fed Animal Models

Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Jung JS, Ryu OH, Choi MG, Choi SS, Suh HW

In the present study, the effect of intrathecal (i.t.) or intracerebroventricular (i.c.v.) administration with cholera toxin (CTX) on the blood glucose level was examined in ICR mice. The i.t. treatment...
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Hop Extract Produces Antinociception by Acting on Opioid System in Mice

Park SH, Sim YB, Kang YJ, Kim SS, Kim CH, Kim SJ, Seo JY, Lim SM, Suh HW

In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a...
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Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse

Park SH, Sim YB, Kang YJ, Lee JK, Lim SS, Suh HW

In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as...
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Lactosylceramide Mediates the Expression of Adhesion Molecules in TNF-alpha and IFNgamma-stimulated Primary Cultured Astrocytes

Lee JK, Kim JK, Park SH, Sim YB, Jung JS, Suh HW

Here we have investigated how lactosylceramide (LacCer) modulates gene expression of adhesion molecules in TNF-alpha and IFNgamma (CM)-stimulated astrocytes. We have observed that stimulation of astrocytes with CM increased the...
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Antinociception Effect and Mechanisms of Campanula Punctata Extract in the Mouse

Park SH, Sim YB, Lim SS, Kim JK, Lee JK, Suh HW

In the present study, the antinociceptive profiles of Campanula punctata extract were examined in ICR mice. The Campanula punctata contain a large dose of saponin. Campanula punctata extract administered orally...
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Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus

Kwon MS, Lee JK, Park SH, Sim YB, Jung JS, Won MH, Kim SM, Suh HW

Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition...
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Activation of PPARalpha Attenuates IFNgamma and IL-1beta-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway

Lee JK, Seo EM, Lee SS, Park SH, Sim YB, Jung JS, Kim SM, Suh HW

The present study demonstrates the effect of fibrates, agonists of PPARalpha on cytokines-induced proliferation in primary cultured astrocytes. Alone or combination treatment with cytokines, such as IL-1beta (10 ng/ml), IFNgamma...
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Antidepressant-like Effect of Kaempferol and Quercitirin, Isolated from Opuntia ficus-indica var. saboten

Park SH, Sim YB, Han PL, Lee JK, Suh HW

Opuntia ficus-indica var. saboten. is widely cultivated in Jeju Island (South Korea) for use in manufacture of health foods. This study described antidepressant effect of two flavonoids (kaempferol and quercitrin)...
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Fetal Well-being Evaluation by Determination of High Frequency Measurement Noise for Fetal Heart Rate Signal

Park IY, Chung DY, Shin JC, Kim SP, Sim YB, Kim SH

  • KMID: 2077512
  • Korean J Obstet Gynecol.
  • 2005 Dec;48(12):2797-2806.
OBJECTIVE: This study was done to propose a new method of determining the cutoff frequency against measurement noise in fetal heart rate signal and to analyze the discriminating value for...
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Nonlinear Dynamic and Chaotic Analysis of Fetal Heart Rate in Fetal Distress

Kim SJ, Shin JC, Chung DY, Sim YB, Yi SH, Kim CY, Kim SP

  • KMID: 2261990
  • Korean J Obstet Gynecol.
  • 2000 Jun;43(6):1071-1079.
OBJECTIVES: For estimating the antenatal fetal wellbeing to develop new analysis method of fetal heart rate(FHR) with electronic Fetal Heart Rate Monitoring(eFHRM) and computer. METHODS: Heart rate signal is received from distressed...
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Surgical Treatment of Intracranial Arachnoid Cysts

Um CS, Koh YC, Sim YB, Kim CH, Lee HK, Park SH, Hwang DY

  • KMID: 2067426
  • J Korean Neurosurg Soc.
  • 1996 Jul;25(7):1429-1437.
Eighteen patients with symptomatic intracranial arachnoid cysts underwent 27 surgical procedures between January 1990 and December 1995. These were analysed with respect to their surgical procedures and results, complications and...
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Multiple Intradural Schwannomas of the Cauda Equina in the Absence of Neurofibromatosis

Choi JH, Kim SM, Choi JW, Ahn KS, Sim YB, Sohn JH, Choi SK

  • KMID: 2188069
  • J Korean Neurosurg Soc.
  • 1996 Jun;25(6):1297-1302.
A case of multiple intradural schwannomas of the cauda equina is reported without evidence of any other manifestations of neurofibromtosis. The patient had symptoms of cauda equina compression. Following a...
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Diagnosis and Management of the Spontaneous Intracranial Vertebral Artery Dissection

Ahn KS, Kim SM, Kim YH, Sim YB, Song JH, Oh SM, Choi SK

  • KMID: 2188057
  • J Korean Neurosurg Soc.
  • 1996 Jun;25(6):1239-1247.
The authors have dealt with six cases of spontaneous intracranial vertebral artery dissection during the past 3 years. Most of the patients were in their fourth or fifth decade of...
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Complication and Reoperation after Surgery for Lumbar Disc Herniation

Kim YH, Ahn KS, Sim YB, Song JH, Choi SK, Kang SK

  • KMID: 2187920
  • J Korean Neurosurg Soc.
  • 1995 Aug;24(8):916-923.
Retrospective analysis of reoperation and complication was made for 186 patients with lumbar herniated disc. The results showed complication rate of 7%(13 cases) and reoperation rate of 10.2%(19 cases). The...
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Nontraumatic Intracranial Dissecting Aneurysm of Vertebral Artery: Case Report

Jung BJ, Ahn KS, Kim YH, Sim YB, Song JH, Oh SM, Choi SK, Kang SK

  • KMID: 2019578
  • J Korean Neurosurg Soc.
  • 1994 Jul;23(7):821-826.
We present two cases with dissecting aneurysm of intracranial vertebral artery. One of them had brain stem infarction and the other one developed subarachnoid hemorrhage. Cerebral angiogram revealed fusiform dilatation...
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