Chonnam Med J.  2016 Jan;52(1):59-63. 10.4068/cmj.2016.52.1.59.

Association of APOE Genotype with Bone Mineral Density in Men and Women: The Dong-gu and Namwon Studies

• Kim SA
• Kweon SS
• Choi JS
• Rhee JA
• Lee YH
• Nam HS
• Jeong SK
• Park KS
• Ryu SY
• Choi SW
• Kim HN
• Song HR
• Oh SH
• Cauley JA
• Shin MH

• KMID: 2152657
• DOI: http://doi.org/10.4068/cmj.2016.52.1.59

Abstract

Many studies have investigated relationships between APOE genotype and bone mineral density (BMD). However, the results of these studies have been inconsistent. Few studies have been carried out in Asian populations. We studied the relationship of the APOE gene polymorphism and BMD in two large population-based studies. The datasets included the Dong-gu Study (3575 men and 5335 women) and the Namwon Study (2310 men, 3512 women). Lumbar spine and femoral neck BMD were measured by dual-energy X-ray absorptiometry. APOE genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The APOE genotypes were classified into APOE E2 (E2/E2 and E2/E3), APOE E3 (E3/E3), and APOE E4 (E3/E4 and E4/E4). The genotype distribution of the study population was in Hardy-Weinberg equilibrium. There were no significant differences among APOE genotype groups in lumbar and femoral neck BMD in either cohort. Our data do not support the hypothesis that the APOE genotype is associated with BMD.

Keyword

Apolipoprotein E; Polymorphism, genetic; Bone density

MeSH Terms

Absorptiometry, Photon
Apolipoproteins E*
Asian Continental Ancestry Group
Bone Density*
Cohort Studies
Dataset
Female
Femur Neck
Genotype*
Humans
Jeollabuk-do*
Male
Polymorphism, Genetic
Spine
Apolipoproteins E

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