Chonnam Med J.  2016 Jan;52(1):59-63. 10.4068/cmj.2016.52.1.59.

Association of APOE Genotype with Bone Mineral Density in Men and Women: The Dong-gu and Namwon Studies

  • 1Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
  • 2Department of Preventive Medicine & Institute of Wonkwang Medical Science Wonkwang University College of Medicine, Iksan, Korea.
  • 3Department of Preventive Medicine, Chungnam National University Medical School, Daejeon, Korea.
  • 4Department of Neurology & Research Institute of Clinical Medicine, Chobuk National University-Chonbuk National University Hospital, Jeonju, Korea.
  • 5Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea.
  • 6Department of Preventive Medicine, Chosun University Medical School, Gwangju, Korea.
  • 7Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea.
  • 8Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea.
  • 9Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA.


Many studies have investigated relationships between APOE genotype and bone mineral density (BMD). However, the results of these studies have been inconsistent. Few studies have been carried out in Asian populations. We studied the relationship of the APOE gene polymorphism and BMD in two large population-based studies. The datasets included the Dong-gu Study (3575 men and 5335 women) and the Namwon Study (2310 men, 3512 women). Lumbar spine and femoral neck BMD were measured by dual-energy X-ray absorptiometry. APOE genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The APOE genotypes were classified into APOE E2 (E2/E2 and E2/E3), APOE E3 (E3/E3), and APOE E4 (E3/E4 and E4/E4). The genotype distribution of the study population was in Hardy-Weinberg equilibrium. There were no significant differences among APOE genotype groups in lumbar and femoral neck BMD in either cohort. Our data do not support the hypothesis that the APOE genotype is associated with BMD.


Apolipoprotein E; Polymorphism, genetic; Bone density
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