J Korean Med Sci.  2015 Jul;30(7):860-865. 10.3346/jkms.2015.30.7.860.

APOE Polymorphism Is Associated with C-reactive Protein Levels but Not with White Blood Cell Count: Dong-gu Study and Namwon Study

Affiliations
  • 1Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital, Gwangju, Korea.
  • 2Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea. mhshinx@paran.com
  • 3Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Korea.
  • 4Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Korea.
  • 5Department of Preventive Medicine, Chungnam National University Medical School, Daejeon, Korea.
  • 6Department of Neurology & Research Institute of Clinical Medicine, Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, Korea.
  • 7Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea.
  • 8Department of Preventive Medicine, Chosun University Medical School, Gwangju, Korea.
  • 9Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea.
  • 10Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA.

Abstract

We evaluated the association of the APOE polymorphism with serum C-reactive protein levels and white blood cell count in two large population-based studies in Korean. The datasets included the Dong-gu study (n = 8,893) and the Namwon Study (n = 10,032). APOE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. Multivariable linear regression analysis was performed to evaluate the relationship of APOE genotypes with C-reactive protein levels and white blood cell count with adjustments for age, sex, body mass index, smoking, diabetes, hypertension, and serum lipids. In the multivariate model, carriers of E3E4 or E4E4 genotype had significantly lower C-reactive protein levels compared with carriers of E3E3 genotype group (0.50 mg/L vs. 0.67 mg/L; 0.37 mg/L vs. 0.67 mg/L, respectively, for the Dong-gu Study and 0.47 mg/L vs. 0.66 mg/L; 0.45 mg/L vs. 0.66 mg/L, respectively, for the Namwon Study). However, there was no difference in white blood cell count among APOE genotypes. We found that the APOE E4 allele is associated with lower C-reactive protein levels, but not white blood cell count. Our results suggest that APOE genotype may influence C-reactive protein levels through non-inflammatory pathway.

Keyword

C-reactive Protein; Apolipoprotein E; Polymorphism, Genetic; Inflammation
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