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Curcumin Enhances the Anticancer Effects of Binimetinib on Melanoma Cells by Inducing Mitochondrial Dysfunction and Cell Apoptosis with Necroptosis

Lee YJ, Heo JY, Kim DS, Choi YS, Kim S, Nam HS, Lee SH, Cho MK

Background: Recent studies suggest that MEK1/2 inhibitors, including binimetinib, significantly improve malignant melanoma (MM) patient survival. Growing evidence suggests that phytochemicals, especially curcumin, can overcome drug resistance in cancer cells...
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First-Pass Recanalization with EmboTrap II in Acute Ischemic Stroke (FREE-AIS): A Multicenter Prospective Study

Baek JH, Kim BM, Suh SH, Jeon HJ, Ihm EH, Park H, Kim CH, Cha SH, Choi CH, Yi KS, Kim JH, Suh S, Kim B, Chang Y, Kim SY, Oh JS, Heo JH, Kim DJ, Nam HS, Kim YD

Objective: We aimed to evaluate the efficacy of EmboTrap II in terms of first-pass recanalization and to determine whether it could yield favorable outcomes. Materials and Methods: In this multicenter, prospective...
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Trends and an Online Survey on the Use of Rigid Bronchoscopy in Korea

Jeong BH, Lee SH, Kim HH, Yoon HI, Eom JS, Park YS, Cho J, Lee T, Kim SJ, Cho HJ, Park CK, Ko Y, Kwon YS, Kim C, Ji W, Choi CM, Seo KH, Nam HS, Kim H

Background: Although almost all interventional pulmonologists agree that rigid bronchoscopy is irreplaceable in the field of interventional pulmonology, less is known about the types of diseases that the procedure is...
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Neutrophil Recruitment in Arterial Thrombus and Characteristics of Stroke Patients with Neutrophil-Rich Thrombus

Cha MJ, Ha J, Lee H, Kwon I, Kim S, Kim YD, Nam HS, Lee HS, Song TJ, Choi HJ, Heo JH

Purpose: Neutrophils contribute to thrombosis. However, there is limited information on the temporal course of neutrophil recruitment in thrombosis, the contribution of neutrophils to thrombus growth, and the characteristics of...
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The Clinical Outcome of Extraskeletal Myxoid Chondrosarcoma

Kong CB, Kim KH, Nam HS, Song WS, Koh JS, Cho WH

Purpose: Extraskeletal myxoid chondrosarcoma (EMC) is an extremely rare malignant mesenchymal neoplasm, accounting for less than 3% of soft tissue sarcomas. This sarcoma is usually characterized by its indolent course....
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Effects of Interleukin-17A on the Early Stages of Arterial Thrombosis in Mice

Park Y, Shim Y, Kwon I, Lee HW, Nam HS, Choi HJ, Heo JH

Purpose: Interleukin (IL)-17A has been suggested to play a role in the growth and organization of thrombi. We examined whether IL-17A plays a role in the early stages of thrombosis...
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Changes of The Epidemiologic Competences after Introductory Course of The Korea - Field Epidemiologist Training Program(K-FETP) in Epidemiologic Intelligence Servise(EIS) Officers

Kim EY, Lee MS, Lee TJ, Lee K, Nam HS, Lee JH, Kim HB, Chun BC, Lee SW, Lee DH, Kim HJ, Kwon SW, Yoon NB, Shin MC, Lim MJ

목적: 이 연구는 2019학년도 역학조사관 입문교육 과정에 참여한 29명의 수습과정생에게 참여형 자기주도 학습 역학조사관 연수 프로그램(FETP)의 효과와 만족도 등 역량 변화를 분석해 그 결과를 향후 과정 개발의 참고 자료로 활용하고자...
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Olmesartan-associated Enteropathy with Acute Kidney Injury

Kang MJ, Min KH, Kim HW, Park SB, Kang DH, Choi CW, Kim SJ, Nam HS, Ryu DG

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Olmesartan-associated Enteropathy with Acute Kidney Injury

Kang MJ, Min KH, Kim HW, Park SB, Kang DH, Choi CW, Kim SJ, Nam HS, Ryu DG

Olmesartan, a recently introduced angiotensin II receptor blocker for hypertension, has been reported to cause drug-induced small bowel enteropathy. The diagnosis of olmesartan-associated enteropathy (OAE) needs clinical suspicion and the...
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High-Resolution Intracranial Vessel Wall MRI Findings Among Different Middle Cerebral Artery Territory Infarction Types

Won SY, Cha J, Choi HS, Kim YD, Nam HS, Heo JH, Lee SK

Objective: Intracranial atherosclerotic stroke occurs through various mechanisms, mainly by artery-to-artery embolism (AA) or branch occlusive disease (BOD). This study evaluated the spatial relationship between middle cerebral artery (MCA) plaques...
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Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study

Yang JH, Jeong JA, Kweon SS, Lee YH, Choi SW, Ryu SY, Nam HS, Park KS, Kim HY, Shin MH

Background and Objectives: Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and...
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Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration

Shim Y, Kwon I, Park Y, Lee HW, Kim J, Kim YD, Nam HS, Park S, Heo JH

Purpose: The ferric chloride (FeCl3)-induced thrombosis model is widely used for thrombosis research. However, it lacks standardization with uncertainty in the exact mechanism of thrombosis. This study aimed to characterize...
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Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study

Yang JH, Kweon SS, Lee YH, Choi SW, Ryu SY, Nam HS, Park KS, Kim HY, Shin MH

Background: Several studies have reported conflicting results regarding the relationship between alcohol consumption and cortisol levels. However, the causality between alcohol consumption and cortisol levels has not been evaluated. Methods: This...
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Neural Substrates of Aphasia in Acute Left Hemispheric Stroke Using VoxelBased Lesion-symptom Brain Mapping

Park EJ, Kim YW, Nam HS, Choi HS, Kim DY

It is unclear how these brain lesions fit into the language processing in acute stroke. In this study, we aimed to investigate the neuroanatomical lesion related to language processing in...
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Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia: The Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia Study

Hong KS, Kwon SU, Park JH, Cha JK, Jung JM, Kim YJ, Lee KB, Sohn SI, Lee YS, Rha JH, Kwon JH, Han SW, Kim BJ, Koo J, Choi JC, Sung SM, Lee SJ, Park MS, Ahn SH, Bang OY, Hwang YH, Nam HS, Park JM, Bae HJ, Kim EG, Lee KY, Oh MS

Background and Purpose: Blood pressure (BP) control is strongly recommended, but BP control rate has not been well studied in patients with stroke. We evaluated the BP control rate with...
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Percutaneous Left Atrial Appendage Occlusion Yields Favorable Neurological Outcomes in Patients with Non-Valvular Atrial Fibrillation

Lee OH, Kim YD, Kim JS, Son NH, Pak HN, Joung B, Yu CW, Lee HJ, Kang WC, Shin ES, Choi Rk, Lim DS, Jung YH, Choi HY, Lee KY, Cho BH, Han SW, Park JH, Cho HJ, Park HJ, Nam HS, Heo JH, So Cy, Cheung GSH, Lam Yy, Freixa X, Tzikas A, Jang Y, Park JW

Background and Objectives: Prior studies have shown that stroke patients treated with percutaneous left atrial appendage occlusion (LAAO) for non-valvular atrial fibrillation (NVAF) experience better outcomes than similar patients treated...
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Prediction of Early Recanalization after Intravenous Thrombolysis in Patients with Large-Vessel Occlusion

Kim YD, Nam HS, Yoo J, Park H, Sohn SI, Hong JH, Kim BM, Kim DJ, Bang OY, Seo WK, Chung JW, Lee KY, Jung YH, Lee HS, Ahn SH, Shin DH, Choi HY, Cho HJ, Baek JH, Kim GS, Seo KD, Kim SH, Song TJ, Kim J, Han SW, Park JH, Lee SI, Heo J, Choi JK, Heo JH, on behalf of the Thrombus Imaging Study Group and the SECRET Study Group

Background and Purpose We aimed to develop a model predicting early recanalization after intravenous tissue plasminogen activator (t-PA) treatment in large-vessel occlusion. Methods Using data from two different multicenter prospective cohorts,...
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Basic Knowledge that Doctors Starting ERCP Should Know

Lee JW, Nam HS

The first endoscopic retrograde cholangiopancreatography (ERCP) wad performed in 1968. With tremendous progress in techniques, instruments and devices, ERCP has played an important role in modern medicine for the diagnosis...
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Factors Related to Regional Variation in the High-risk Drinking Rate in Korea: Using Quantile Regression

Kim ES, Nam HS

Objectives: This study aimed to identify regional differences in the high-risk drinking rate among yearly alcohol users in Korea and to identify relevant regional factors for each quintile using quantile...
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Cilostazol and Probucol for Cognitive Decline after Stroke: A Cognitive Outcome Substudy of the PICASSO Trial

Lim JS, Kwon SU, Yu KH, Yu S, Park JH, Lee BC, Oh MS, Kim YJ, Rha JH, Hwang YH, Lee JS, Heo SH, Ahn SH, Seo WK, Park JM, Lee JH, Kwon JH, Sohn SI, Jung JM, Kim HY, Kim EG, Cha JK, Park MS, Nam HS, Bae HJ, Kim DE, Park J, Kang Y, Choi J, Lee J

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