J Korean Med Sci.  2018 Jun;33(23):e165. 10.3346/jkms.2018.33.e165.

Association between Plasma Pentraxin 3 Levels and Bone Mineral Density in Elderly Koreans: the Dong-gu Study

  • 1Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea. ujingogo@paran.com
  • 2Department of Nursing, Nambu University, Gwangju, Korea.
  • 3Department of Preventive Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
  • 4Department of Preventive Medicine, Chosun University Medical School, Gwangju, Korea.
  • 5Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Korea.


We investigated the association between pentraxin 3 (PTX3), a novel inflammatory marker, and bone mineral density (BMD) in the general Korean population.
We selected a sub-cohort of 1,440 subjects (757 men and 683 women) from participants in the community-based Dong-gu Study. The mean age was 66.0 ± 8.1 years for men and 63.7 ± 7.9 years for women. The plasma PTX3 levels were measured using an enzyme-linked immunosorbent assay, and BMD was measured in the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Linear regression analyses were used to evaluate the association between the plasma PTX3 levels and BMD.
PTX3 was inversely associated with the BMD of the lumbar spine (P = 0.010) and femoral neck (P < 0.001) in men but not in women. For men, the association with the BMD of the femoral neck remained after adjustment for multiple comparison (P = 0.020).
This study suggests that PTX3 levels might be inversely associated with BMD in elderly men.


Pentraxin 3; Bone Mineral Density; Korean; Elderly; Inflammatory Marker
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