Immune Netw.  2014 Aug;14(4):171-181. 10.4110/in.2014.14.4.171.

The Roles of Innate Lymphoid Cells in the Development of Asthma

  • 1Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-744, Korea.
  • 2Department of Medical Science, Seoul National University College of Medicine and Hospital, Seoul 110-744, Korea.


Asthma is a common pulmonary disease with several different forms. The most studied form of asthma is the allergic form, which is mainly related to the function of Th2 cells and their production of cytokines (IL-4, IL-5, and IL-13) in association with allergen sensitization and adaptive immunity. Recently, there have been many advances in understanding non-allergic asthma, which seems to be related to environmental factors such as air pollution, infection, or even obesity. Cells of the innate immune system, including macrophages, neutrophils, and natural killer T cells as well as the newly described innate lymphoid cells, are effective producers of a variety of cytokines and seem to play important roles in the development of non-allergic asthma. In this review, we focus on recent findings regarding innate lymphoid cells and their roles in asthma.


Airway hyperreactivity; Asthma; Innate lymphoid cells; Allergic asthma; Non-allergic asthma
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