Allergy Asthma Respir Dis.  2014 Nov;2(5):317-325. 10.4168/aard.2014.2.5.317.

Innate immunity in asthma

Affiliations
  • 1Department of Medical Science, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. hykim11@snu.ac.kr

Abstract

Asthma is a complex and heterogeneous disease with several phenotypes. Most studies have focused on allergic asthma associated with allergen sensitization and adaptive immunity. On the other hand, nonallergic asthma is associated with a number of environmental factors such as infection, air pollution, or obesity, and requires innate immunity rather than adaptive immunity. In the lung, a number of innate immune cells and mechanisms have evolved to lead lung inflammation and asthma. These innate mechanisms include innate cytokines and various innate cells, including innate lymphoid cells, natural killer cells, as well as gammadelta T cells, which together produce a wide range of cytokines, independent of adaptive immunity and conventional antigens. Here, we review the most recent works regarding innate immune cells and the mechanisms underlying their role in asthma.

Keyword

Airway hyperreactivity; Innate immunity; Innate lymphoid cells; Natural killer T cells; Gammadelta T cells
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