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Innate Lymphoid Cells in the Airways: Their Functions and Regulators

Orimo K, Saito H, Matsumoto , Morita H

Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways—including structural cells and immune cells—interact to form a precise defense system...
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Anticoccidial Effect of CS 32 Compounds Against Eimeria tenella Infection in Chickens

Jang K, Kim SE, Shim KM, Park HJ, Kim S, Min W, Yoo JC, Kang SS

Coccidiosis-causing Eimeria species are transmitted in poultry via the oral-fecal route and can lead to hemorrhagic diarrhea and mortality. This results in enormous economic losses in the poultry industry. Furthermore,...
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Critical Points on the Use of Biologicals in Allergic Diseases and Asthma

Agache I, Cojanu C, Laculiceanu A, Rogozea L

Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There...
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CD24⁺ Cell Depletion Permits Effective Enrichment of Thymic iNKT Cells While Preserving Their Subset Composition

Park JY, Kwon J, Kim EY, Fink J, Kim HK, Park JH

Invariant NKT (iNKT) cells are a small subset of thymus-generated T cells that produce cytokines to control both innate and adaptive immunity. Because of their very low frequency in the...
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Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis

Jung YK, Kang YM, Han S

The enhanced differentiation and activation of osteoclasts (OCs) in the inflammatory arthritis such as rheumatoid arthritis (RA) and gout causes not only local bone erosion, but also systemic osteoporosis, leading...
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Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity

Oh SJ, Lee JK, Shin OS

Immunosenescence is characterized by a progressive deterioration of the immune system associated with aging. Multiple components of both innate and adaptive immune systems experience aging-related changes, such as alterations in...
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The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation

Hossain FM, Choi JY, Uyangaa E, Park SO, Eo SK

Asthma is one of the most common and chronic diseases characterized by multidimensional immune responses along with poor prognosis and severity. The heterogeneous nature of asthma may be attributed to...
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Murine γδ T Cells Render B Cells Refractory to Commitment of IgA Isotype Switching

Han HJ, Jang YS, Seo GY, Park SG, Kang SG, Yoon SI, Ko HJ, Lee GS, Kim PH

γδ T cells are abundant in the gut mucosa and play an important role in adaptive immunity as well as innate immunity. Although γδ T cells are supposed to be...
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A Salmonella Typhi ghost induced by the E gene of phage φX174 stimulates dendritic cells and efficiently activates the adaptive immune response

Won G, Eo SK, Park SY, Hur J, Lee JH

Previously, we genetically engineered a Salmonella Typhi bacterial ghost (STG) as a novel inactivated vaccine candidate against typhoid fever. The underlying mechanism employed by the ghost in stimulating the adaptive...
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Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485

Rakhmanova V, Jin M, Shin J

Mast cells integrate innate and adaptive immunity and are implicated in pathophysiological conditions, including allergy, asthma, and anaphylaxis. Cross-linking of the high-affinity IgE receptor (FcεRI) initiates diverse signal transduction pathways...
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Wolves Trapped in the NETs–The Pathogenesis of Lupus Nephritis

Kim Y, Shim SC

Systemic lupus erythematous (SLE) is a systemic autoimmune disease with multi-organ inflammation caused by the production of pathogenic autoantibodies and immune complexes reflecting a global loss of tolerance. Lupus nephritis...
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Preliminary assessment of correlation between T-lymphocyte responses and control of porcine reproductive and respiratory syndrome virus (PRRSV) in piglets born after in-utero infection of a type 2 PRRSV

Cha SH, Bandaranayaka-Mudiyanselage C, Bandaranayaka-Mudiyanselage CB, Ajiththos , Yoon KJ, Gibson KA, Yu JE, Cho IS, Lee SS, Chung CJ

A preliminary study into the protective mechanisms of adaptive immunity against porcine reproductive and respiratory syndrome virus (PRRSV) in piglets (n = 9) born to a gilt challenged intranasally with...
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Macrophages and Inflammation

Lee CH, Choi EY

Inflammation is a normal physiological response to an infection or injury, such as aggression by microbes, trauma, or heat and radiation. Inflammation works to maintain homeostasis and is a highly...
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T Cell's Sense of Self: a Role of Self-Recognition in Shaping Functional Competence of Naïve T Cells

Kim HO, Cho JH

Post-thymic naïve T cells constitute a key cellular arm of adaptive immunity, with a well-known characteristic of the specificity and robustness of responses to cognate foreign antigens which is presented...
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The Big Vitamin D Mistake

Papadimitriou DT

Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities' decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate...
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Comparison of humoral and cell-mediated immunity in three different C57BL/6N mouse substrains

Kim HR, Choi JY, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic...
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Comparative study of the immunological characteristics of three different C57BL/6N mouse substrains

Choi JY, Kim HR, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

Inbred mice, a systematically developed homogeneous animal, have been developed to maintain experimental reproducibility and to minimize experimental variables in animal-based studies. In particular, C57BL/6 mice are frequently used in...
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Alteration in Leukocyte Subsets and Expressions of FcγR and Complement Receptors among Female Ragpickers in Eastern India

Mondal NK, Siddique S, Banerjee M, Roychoudhury S, Mukherjee , Slaughter , Lahiri T, Ray MR

BACKGROUND: There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their...
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The Role of Lipids in Development of Allergic Responses

del Moral , Martínez-Naves E

Most allergic diseases are caused by activation of Th2 type immune responses resulting in the production of specific IgE against proteins found in normally harmless substances such as pollen, mites,...
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Origins and History of Laboratory Medicine

Lee HJ, Oh SH, Chang CL

Medical diagnostics plays a significant role in clinical decisions. The first medical laboratory test to be developed was urine analysis, in which urine properties were analyzed for diagnosis. Urine analysis...
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