Korean J Gastrointest Endosc.  2006 Oct;33(4):230-234.

Two Cases of Gastric Mucosal Calcinosis

  • 1Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea. docyeo@hanmail.net
  • 2Department of Pathology, Daegu Fatima Hospital, Daegu, Korea.


Gastric mucosal calcinosis (GMC) is a very rare condition that is characterized by the nodular deposition of calcium salts in the gastric mucosa. It has been associated with renal failure, gastric cancer, ingestion of aluminum- containing antacids and the use of sucralfate in organ transplant patients. The etiology of this condition is uncertain, but several theories have been proposed; the condition is due secondarily to hyperparathyroidism in renal failure and to the alkalinization of the gastric mucosa. We report here on two patients who had long-term use of bismuth and/or aluminum-containing antacids to treat their gastro-esophageal reflux symptoms. The esophagogastroduodenoscopy revealed acute gastritis patterns, and GMC was confirmed histologically with biopsy. When one patient stopped ingesting bismuth-containing antacid solution, the follow-up esophagogastroduodenoscopy and the biopsy revealed a completely improved state. We report here on these interesting cases and we include a brief review of the literature.


Gastric mucosal calcinosis; Bismuth; Aluminum-containing antacids
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