Korean J Nephrol.  2010 Mar;29(2):270-275.

Mandibular Enlargement, Metastatic Pulmonary Calcification and Gastric Mucosal Calcinosis in a Patient with Chronic Kidney Disease-mineral Bone Disorder

Affiliations
  • 1Division of Nephrology, Department of Internal Medicine, College of Medicine, Korea University, Korea. yjkwon@korea.ac.kr
  • 2Division of Nephrology, Department of Internal Medicine, Wonkwang University, Korea.
  • 3Division of Breast and Endocrine Surgery, Department of surgery, Korea University, Korea.

Abstract

Secondary hyperparathyroidism is one of the most common complications of patients with chronic kidney disease (CKD). Mandibular enlargement, metastatic pulmonary calcification, and gastric mucosal calcinosis are rare complications in these patients. The defect of calcium and phosphorus metabolism may precipitate pathologic calcification at diverse organs and soft tissue, and change bone architecture. In case of involving periarticular area, patients usually present with localized swelling, pain, and reduced mobility in affected sites. However, in case of organ involvement, except in an advanced stage of disease, there are no specific symptoms. Among these patients, treatment strategies include tight control of calcium and phosphate levels, parathyroidectomy for hyperparathyroidism, renal transplantation, and local excision of calcific lesions. We report a case of mandibular enlargement, metastatic pulmonary calcification, and gastric mucosal calcinosis due to CKD with improvement 3 months after medical and surgical treatment.

Keyword

Secondary hyperparathyroidism; Pathologic calcification

MeSH Terms

Calcinosis
Calcium
Humans
Hyperparathyroidism
Hyperparathyroidism, Secondary
Kidney
Kidney Transplantation
Parathyroidectomy
Phosphorus
Renal Insufficiency, Chronic
Calcium
Phosphorus
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