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Rare PTH Gene Mutations Causing Parathyroid Disorders: A Review

Lee JH, Davaatseren M, Lee S

Since parathyroid hormone (PTH) was first isolated and its gene (PTH) was sequenced, only eight PTH mutations have been discovered. The C18R mutation in PTH, discovered in 1990, was the...
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Performance of F-18 Fluorocholine PET/CT for Detection of Hyperfunctioning Parathyroid Tissue in Patients with Elevated Parathyroid Hormone Levels and Negative or Discrepant Results in conventional Imaging

Uslu-BeÅŸli L, Sonmezoglu K, Teksoz S, Akgun E, Karayel E, Pehlivanoglu H, Khosroshahi BR, Ocak M, Kabasakal , Sager S, Bukey Y

OBJECTIVE: Our aim was to assess the diagnostic performance of F-18 fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) in detecting hyperfunctioning parathyroid tissue (HPT) in patients with elevated parathyroid hormone...
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Current Understanding of Mineral and Bone Disorders of Chronic Kidney Disease and the Scientific Grounds on the Use of Exogenous Parathyroid Hormone in Its Management

Pazianas M, Miller PD

Chronic Kidney disease (CKD) disturbs mineral homeostasis leading to mineral and bone disorders (MBD). Serum calcium and phosphate (Pi) remain normal until the late stages of CKD at the expense...
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Diagnosis and Treatment of Brown Tumor

Cho YJ, Cho YM, Na SM, Jung ST

PURPOSE: Brown tumor is a tumor-like disease that can occur as a linked disease of hyperparathyroidism which can causes osteoporosis, osteitis fibrosa cystica, pathologic fractures. Brown tumor has been reported...
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Predictors of early postoperative hypocalcemia after total parathyroidectomy in renal hyperparathyroidism

Tan PG, Ab. Hadi I, Zahari Z, Yahya MM, Wan Zain W, Wong MP, Ramely R, Md Hashim , Syed Abd. Aziz SH, Zakaria Z, Zakaria AD

PURPOSE: Patients with secondary hyperparathyroidism are at high risk for developing postoperative hypocalcemia. However, there are limited data regarding predictors of postoperative hypocalcemia in renal failure patient with secondary hyperparathyroidism....
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Intrathyroidal Parathyroid Carcinoma in Chronic Kidney Disease: A Case Report and Review of Literature

Kim MK, Song CM, Tae K, Ji YB

When parathyroid carcinoma occurs in the thyroid gland, it is very difficult to diagnose before surgery because imaging studies and aspiration cytology cannot distinguish parathyroid carcinoma from thyroid nodule or...
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Impact of Subtotal Parathyroidectomy on Clinical Parameters and Quality of Life in Hemodialysis Patients with Secondary Hyperparathyroidism

El-kholey , Ibrahim GE, Elshahat O, El-Kannishy G

BACKGROUND: Impairment of quality of life (QOL) is a key clinical characteristic of patients with end-stage renal disease (ESRD), and can be especially severe in the presence of secondary hyperparathyroidism...
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Intraoperative Parathyroid Hormone Monitoring in the Surgical Management of Sporadic Primary Hyperparathyroidism

Khan ZF, Lew JI

Intraoperative parathyroid hormone monitoring (IPM) has been shown to be a useful adjunct during parathyroidectomy to ensure operative success at many specialized medical centers worldwide. Using the Miami or “>50%...
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Changing Trends in Preoperative Localization and Surgical Techniques for the Treatment of Primary Hyperparathyroidism in a Single Tertiary Center

Lee J, Kim SJ, Yu HW, Chai YJ, Choi JY, Lee KE

PURPOSE: Primary hyperparathyroidism (PHPT) is caused by the oversecretion of parathyroid hormone (PTH), resulting in increased serum calcium levels. The aim of this study was to analyze changing trends in...
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Subtotal Parathyroidectomy for Tertiary Hyperparathyroidism: a Case Report and Literature Review

Jang Y, Kim GH, Park JH, Tae K

Despite the correction of secondary renal hyperparathyroidism after successful kidney transplantation, some recipients have persistent hyperparathyroidism due to autonomous hypertrophied parathyroid glands. St. Goar first identified and termed this disease...
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Imaging of Thoracic Wall Abnormalities

Semionov A, Kosiuk J, Ajlan A, Discepola

Identification of certain abnormalities of the chest wall can be extremely helpful in correctly diagnosing a number of syndromic conditions and systemic diseases. Additionally, chest wall abnormalities may sometimes constitute...
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Primary hyperparathyroidism versus familial hypocalciuric hypercalcemia: a challenging diagnostic evaluation in an adolescent female

Tosur M, Lopez ME, Paul DL

Primary hyperparathyroidism (PHPT) and familial hypocalciuric hypercalcemia (FHH) have significantly different treatment approaches, so physicians must be careful to differentiate these 2 diseases. Herein, we report a 14-year-old female who...
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Long-term effectiveness of cinacalcet in non-dialysis patients with chronic kidney disease and secondary hyperparathyroidism

Pérez-Ricart A, Galicia-Basart M, Comas-Sugrañes D, Cruzado-Garrit JM, Segarra-Medrano A, Montoro-Ronsano JB

BACKGROUND: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Cinacalcet use is controversial in non-dialysis patients. METHODS: This retrospective observational study recruited patients receiving cinacalcet (off-label use)...
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Limited usefulness of calcimimetics for secondary hyperparathyroidism in non-dialysis chronic kidney disease

Abbas F, Coyne DW

No abstract available.
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Parathyroid Cancer: Comparison with Benign Hyperparathyroidism

Seok JY, Lee JH, Lee S, Kang SH, Chung YS

PURPOSE: The preoperative diagnosis of parathyroid cancer (PC) is challenging. The purpose of this study was to identify the differences between PC and benign primary hyperparathyroidism. METHODS: The medical records of...
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A Case Report: Total Parathyroidectomy with Autotransplantation for Secondary Hyperparathyroidism

Kim SH, Seo DH, Hwang SD, Kim JW

Secondary hyperparathyroidism (HPT) usually result from parathyroid gland hyperplasia that produces excess parathyroid hormone (PTH). Decreased renal function leads to elevate serum phosphate levels and reduce vitamin D production, which...
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Reference range of random urinary calcium creatinine ratio in North Indian children and adolescents

Marwaha RK, Garg MK, Dang N, Mithal A, Narang A, Chadha A, Gupta N, Kumar MR

PURPOSE: Urinary calcium creatinine ratio (UCaCrR) is a reliable indicator for monitoring hypercalciuria following vitamin D supplementation. However, the reference range varies from region to region. Previous studies did not...
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A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid

Park SK, Lee MW, Han IS, Park YJ, Han SY, Park JW, Lee BE, Kim GH, Kim SS

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant hereditary disorder caused by germline mutation of the MEN1 gene. It is characterized by tumors of the anterior pituitary...
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Ectopic Mediastinal Parathyroid Adenoma in a Patient with Chronic Kidney Disease: A Case Report

Choo DM, Kim JH, Kim SS

We report an ectopic mediastinal parathyroid adenoma in a patient with chronic kidney disease who presented with refractory hypercalcemia. Technetium-99m-sestamibi scintigraphy is a valuable imaging technique for the detection of...
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First Case of Plasma Cell Myeloma With Brown Tumor Features Unrelated to Hyperparathyroidism

Kim H, Kim K, Cho SR, Kim HJ, Kim SH

No abstract available.
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