Korean J Lab Med.  2004 Dec;24(6):352-357.

Two Cases of Myelofibrosis Mimicking Malignant Lymphoma in Computed Tomography of Abdomen: A Case of Autoimmune Myelofibrosis associated with Systemic Lupus Erythematosus Showing Extensive Lymphadenopathy and A Case of Chronic Idiopathic Myelofibrosis wit

Affiliations
  • 1Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, Korea. kal1119@hanmail.net

Abstract

Myelofibrosis results from stimulation of bone marrow stromal fibroblasts by fibrogenic cytokines elaborated by neoplastic or reactive cells in the marrow. Chronic idiopathic myelofibrosis should be differentiated from secondary myelofibrosis resulting from bone marrow involvement of malignant lymphoma because these diseases have different therapeutic strategies. Myelofibrosis in systemic lupus erythematosus is an uncommon but well-recognized complication, and identifying an autoimmune myelofibrosis is important in diagnosing this benign cause of myelofibrosis. We report two cases of myelofibrosis presenting the clinical and radiologic findings that mimicked malignant lymphoma -a case of autoimmune myelofibrosis associated with systemic lupus erythematosus showing extensive lymphadenopathy and a case of chronic idiopathic myelofibrosis with focal intrasplenic extramedullary hematopoiesis- and discuss the importance of the clinical information and radiologic findings for the pathologic diagnosis of myelofibrosis.

Keyword

Computed tomography; Chronic idiopathic myelofibrosis; Lymphoma; Extramedullary hematopoiesis; Systemic lupus erythematosus; Autoimmune myelofibrosis; Lymphadenopathy
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