Korean Circ J.  2002 Jul;32(7):556-565. 10.4070/kcj.2002.32.7.556.

Apolipoprotein B-100/Apolipoprotein A-I Ratio is on Useful Indicator for Coronary Artery Disease in Koreans

• Kim HK
• Kim HS
• Oh S
• Chae IH
• Kim LA
• Choi EK
• Park KW
• Cho HJ
• Kim CH
• Sohn DW
• Oh BH
• Lee MM
• Park YB
• Choi YS

• KMID: 2093853
• DOI: http://doi.org/10.4070/kcj.2002.32.7.556

Abstract

BACKGROUND AND OBJECTIVES: Little is known about the relationship between the apolipoprotein (apo) B-100, or the apo B-100/apo A-I ratio, and coronary artery disease (CAD). The aim of this study was to investigate this association.
SUBJECTS AND METHODS
Our study was carried out on 194 patients who had undergone elective coronary angiography (CAG), but had received no lipid-lowering medication. Patients with acute myocardial infarction were excluded. Stenosis of >or=50% in 1 or more coronary arteries was classified as CAD (+).
RESULTS
HDL-C and apo A-I were significantly higher in females than in males (p=0.009 and 0.036). In our population we found that the apo A-I, HDL-C and the apo B-100/apo A-I ratio were significantly related to CAD (p=0.001, 0.006, and 0.007 respectively). In the male group (n=111), the apo B-100/apo A-I ratio was the only parameter statistically significant to CAD after correcting for age, diabetes mellitus and hypertension. Whereas, in the female group (n=83), the apo B/apo A-I ratio, apo B-100/apo A-I ratio, apo B-100, nonHDL-C, triglyceride, apo B, total cholesterol and low-density lipoprotein cholesterol were all significantly related to CAD (p=0.002, 0.003, 0.003, 0.007, 0.007, 0.009, 0.012 and 0.012 respectively). Of these parameters only the apo B-100/apo A-I ratio was significantly related to CAD in both female and male group.
CONCLUSION
The apo B-100/apo A-I ratio is an useful indicator for discriminating between CAD (+) and CAD (-).

Keyword

Apolipoproteins; Coronary disease

MeSH Terms

Apolipoprotein A-I
Apolipoprotein B-100
Apolipoproteins B
Apolipoproteins*
Cholesterol
Constriction, Pathologic
Coronary Angiography
Coronary Artery Disease*
Coronary Disease
Coronary Vessels*
Diabetes Mellitus
Female
Humans
Hypertension
Lipoproteins
Male
Myocardial Infarction
Triglycerides
Apolipoprotein A-I
Apolipoprotein B-100
Apolipoproteins
Apolipoproteins B
Cholesterol
Lipoproteins