Korean J Anat.  2006 Oct;39(5):417-424.

Fine Structure of Goblet Cell Regeneration on Experimental Colitis Induced by Dextran Sulfate Sodium

• Park IS

Abstract

Ulcerative colitis is recognized as important causes of gastrointestinal diseases in children and adults. I observed the fine structural changes of goblet cell regeneration after experimental ulcerative colitis induced by dextran sulfate sodium (DSS) in rats. Experimental colitis was induced with 5% DSS in the drinking water for 5 days, and the healing groups were fed with pure water for 7 days thereafter. In the early stage of goblet cell regeneration (repair 3 days group), granular endoplasmic reticulums were developed around the nucleus, and some mucigen granules were observed around the nucleus. In the middle stage of goblet cell regeneration (repair 5 days group), Golgi complexes were well developed in the upper region to the nucleus, and many mucous granules were observed. In the matured goblet cell regeneration (repair 7 days group), many mucous granules appeared in the upper region of the cell, and cell organelles were located in the base and periphery of the cell. These results suggest that the goblet cell was completely reconstructed within 7 days after ulcerative colitis.

Keyword

Colitis; Goblet cell; Fine structure; Regeneration; DSS (dextran sulfate sodium)

MeSH Terms

Adult
Animals
Child
Colitis*
Colitis, Ulcerative
Dextran Sulfate*
Dextrans*
Drinking Water
Endoplasmic Reticulum, Rough
Gastrointestinal Diseases
Goblet Cells*
Golgi Apparatus
Humans
Organelles
Rats
Regeneration*
Water
Dextran Sulfate
Dextrans
Drinking Water
Water