Korean J Anat.  2006 Feb;39(1):27-33.

Histological Study of Experimental Colitis Induced by Dextran Sulfate Sodium

• Park IS

Abstract

Inflamatory bowel disease is the general medical terminology on chronic inflammatory illness of unknown origin, but it is considered that environmental, genetical, immunological factors may develop this chronic disease. I examined the histological changes on the experimental ulcerative colitis induced by dextran sulfate sodium(DSS) in rats. Experimental colitis was induced with 5% DSS in the drinking water for 5days in rats (experimental group). And the repair group were treated with 5% DSS for 5days and with pure water after 7days in rats. In experimental group, there are many inflammatory finding in colon of rat which contained loss of body weight, crypt erosion, recruitment of inflammatory cells, submucosal edema. In repair group, the inflammation was recovered that the body weight was incerased, the crypt was recovered. And Ki 67 immunoreaction were restricted lower 1/3 crypt in normal group but positive Ki 67 reaction appeared in the repaired all region. In this study, DSS was induced experimental colitis and the colitis was repaired when we stoped DSS supply. And the Ki 67 during repaired period were overproduction.

Keyword

Colitis; DSS (dextran sulfate sodium); Crypt; Ki 67

MeSH Terms

Animals
Body Weight
Chronic Disease
Colitis*
Colitis, Ulcerative
Colon
Dextran Sulfate*
Dextrans*
Drinking Water
Edema
Immunologic Factors
Inflammation
Rats
Water
Dextran Sulfate
Dextrans
Drinking Water
Immunologic Factors
Water