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Ventilator support in the pretransplant period predisposes early graft failure after deceased donor liver transplantation

Lee N, Cha S, Kim J, Lee Y, Kang E, Kim HJ, Hong SH, Rhu J, Choi GS, Joh JW

Purpose: Deceased donor liver transplantation (DDLT) recipients in Korea are generally sicker due to an increasing organ shortage. In the present study, the risk factors for early 30-day liver graft...
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Three-Dimensional Printing Technology Using Biomaterials for Bone Regeneration

Park SH

Three-dimensional printing (3DP), or additive manufacturing, has attracted considerable attention for patient-specific medical applications. Among the standard technical groups, powder bed fusion (PBF) and material extrusion (ME) are preferred for fabricating...
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Measuring Glutathione Regeneration Capacity in Stem Cells

Kim J, Gong YX, Jeong EM

Glutathione (GSH) is a chief cellular antioxidant, affecting stem cell functions. The cellular GSH level is dynamically altered by the redox buffering system and transcription factors, including NRF2. Additionally, GSH...
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Enhanced Bone Formation by Rapidly Formed Bony Wall over the Bone Defect Using Dual Growth Factors

Park J, Jung N, Lee DJ, Oh S, Kim S, Cho SW, Kim JE, Moon HS, Park YB

BACKGROUND: In guided bone regeneration (GBR), there are various problems that occur in the bone defect after the wound healing period. This study aimed to investigate the enhancement of the...
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Wnt/b-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells

Yao XT, Li Pp, Liu J, Yang YY, Luo ZL, Jiang HT, He WG, Luo HH, Deng YX, He BC

BACKGROUND: All-trans retinoic acid (ATRA) promotes the osteogenic differentiation induced by bone morphogenetic protein 9 (BMP9), but the intrinsic relationship between BMP9 and ATRA keeps unknown. Herein, we investigated the...
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Application of cold atmospheric microwave plasma as an adjunct therapy for wound healing in dogs and cats

Yoo J, Kang YH, Baek SJ, Hwang CY

Background: Cold atmospheric plasma is a novel innovative approach for wound care, and it is currently underrepresented in veterinary medicine. Objectives: To investigate the efficacy and safety of using cold atmospheric...
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Combined surgical therapy for the treatment of combined supraand intrabony defects in peri-implantitis

Ahn SH, Lee JM, Suh JY, Kim YG

Various methods have been proposed to treat peri-implantitis; however, these methods have not been fully established as yet. The bone destruction pattern of the peri-implant bone can be observed as...
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Tree of life: endothelial cell in norm and disease, the good guy is a partner in crime!

Marzoog BA

Undeniably, endothelial cells (EC) contribute to the maintenance of the homeostasis of the organism through modulating cellular physiology, including signaling pathways, through the release of highly active molecules as well...
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A Comparative Study of Dichloromethane and Ethyl Acetate Root Extracts of Celosia trigyna: Phytochemical and Wound Healing Effect Analyses

Ofusori AE, Raharjo Y, Ofusori DA, Adekunle VO

Background: Celosia species have been validated to possess antimicrobial, anti-inflammatory, and antioxidant potential. This study was thus designed to comparatively determine the effect of dichloromethane and ethyl acetate root extracts...
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Are There Hopeful Therapeutic Strategies to Regenerate the Infarcted Hearts?

Oh GC, Choi YJ, Park BW, Ban K, Park HJ

Ischemic heart disease remains the primary cause of morbidity and mortality worldwide. Despite significant advancements in pharmacological and revascularization techniques in the late 20th century, heart failure prevalence after myocardial infarction...
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Application of Nerve Guided Conduits for Recurrent Laryngeal Nerve Regeneration

Kim JM, Choi JS

Recurrent laryngeal nerve injury is a common complication of thyroid surgery that can cause communication disorders, aspiration, and swallowing difficulties. Despite extensive knowledge of the pathology and regeneration mechanisms of...
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Tissue engineering in plastic and reconstructive surgery: fostering advances in the 21st century via an understanding of the present state of the art and future possibilities

Anand M, Bhagania M, Kaur K

Tissue engineering is a subfield of regenerative medicine that has been hailed as the most cutting-edge medical and surgical achievement to date. Tissue engineering aims to restore or construct whole...
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Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration

Zhou X, Yu M, Chen D, Deng C, Zhang Q, Gu X, Ding F

BACKGROUND: Repair of long-distance peripheral nerve defects remains an important clinical problem. Nerve grafts incorporated with extracellular vesicles (EVs) from various cell types have been developed to bridge peripheral nerve...
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Endothelial cell autophagy in the context of disease development

Marzoog BA

Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation...
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Effects of retinoid-loaded hyaluronic acid nanomicelles on vaginal epithelium in a murine menopause model

Kim T, Chung HS, Lee HS, Uthaman S, Park IK, Park K

Purpose: This study aimed to develop hyaluronic acid (HA)-based, retinoic acid (RA)-containing nanomicelles and to investigate the effects of these newly developed nanomicelles on regeneration of the vaginal epithelium and...
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rhBMP-2-Conjugated Three-Dimensional-Printed Poly(L-lactide) Scaffold is an Effective Bone Substitute

Hong YR, Kim TH, Park KH, Kang J, Lee K, Park EK, Kwon TG, Lim JO, Oh CW

BACKGROUND: Bone growth factors, particularly bone morphogenic protein-2 (BMP-2), are required for effective treatment of significant bone loss. Despite the extensive development of bone substitutes, much remains to be desired...
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Trends in Saliva Research and Biomedical Clinical Applications

Park S, Lee E, Shin J, Jeong T

Function of salivary gland and saliva composition can be an indicator of individual’s health status. Recently, saliva has been thought to have a high potential for usage in the biomedical...
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Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H 2O2-induced HaCaT Cell

Choi JH, Lee S, Han HJ, Kwon J

Oxidative stress in skin cells can induce the formation of reactive oxygen species (ROS), which are critical for pathogenic processes such as immunosuppression, inflammation, and skin aging. In this study,...
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Recent innovations in renal replacement technology and potential applications to transplantation and dialysis patients: a review of current methods

Dominy CL, Shamsian EB, Okhawere KE, Korn TG, Meilika K, Badani K

The current standard of care for patients with end-stage renal disease (ERSD) is a kidney transplant or dialysis when a donor organ isnot available. The growing gap between patients who...
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Wnt signaling in liver regeneration, disease, and cancer

Zou G, Park JI

The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and...
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