- Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression
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Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q
- KMID: 2471035
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):137-147.
- doi: 10.4196/kjpp.2020.24.2.137
Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis... -
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- Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis
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Zhong X, Surh YJ, Do SG, Shin E, Shim KS, Lee CK, Na HK
- KMID: 2454672
- J Cancer Prev.
- 2019 Jun;24(2):129-138.
- doi: 10.15430/JCP.2019.24.2.129
BACKGROUND: Baicalein is a bioactive flavone that is originally extracted from the root of Scutellaria baicalensis Georgi. This plant has long served as Chinese herbal medicine in the management of... -
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- Anti-inflammatory effects of mulberry twig extracts on dextran sulfate sodium-induced colitis mouse model
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Cui X, Kim E
- KMID: 2444937
- J Nutr Health.
- 2019 Apr;52(2):139-148.
- doi: 10.4163/jnh.2019.52.2.139
PURPOSE: Ulcerative colitis is a common inflammatory bowel disease. Prolonged colitis can be a risk factor for the development of colorectal cancer. Mulberry twig (MT, Sangzhi), a dry branch of... -
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- T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
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Kwon SH, Seo EB, Lee SH, Cho CH, Kim SJ, Kim SJ, Kim HR, Ye SK
- KMID: 2419775
- Immune Netw.
- 2018 Aug;18(4):e30.
- doi: 10.4110/in.2018.18.e30
Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD). Our previous study demonstrated that STAT3 activation by IL-6... -
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- Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice
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Yang JY, Zhong X, Kim SJ, Kim DH, Kim HS, Lee JS, Yum HW, Lee J, Na HK, Surh YJ
- KMID: 2416948
- J Cancer Prev.
- 2018 Mar;23(1):18-24.
- doi: 10.15430/JCP.2018.23.1.18
BACKGROUND: Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported... -
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- Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse
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Han KH, Park JM, Jeong M, Han YM, Go EJ, Park J, Kim H, Han JG, Kwon O, Hahm KB
- KMID: 2389354
- Gut Liver.
- 2017 Sep;11(5):655-666.
- doi: 10.5009/gnl16496
BACKGROUND/AIMS: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes... -
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- Açaà Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice
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Choi YJ, Choi YJ, Kim N, Nam RH, Lee S, Lee HS, Lee HN, Surh YJ, Lee DH
- KMID: 2412191
- Gut Liver.
- 2017 Mar;11(2):243-252.
- doi: 10.5009/gnl16068
BACKGROUND/AIMS: The aim of this study was to investigate the protective effect of açaà against azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colorectal cancer development. METHODS: The effect of açaà on tumorigenesis was... -
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- The Therapeutic Efficacy of Tonsil-derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-induced Acute Murine Colitis Model
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Song EM, Jung SA, Lee KE, Jang JY, Lee KH, Tae CH, Moon CM, Joo YH, Kim SE, Jung HK, Shim KN
- KMID: 2383421
- Korean J Gastroenterol.
- 2017 Feb;69(2):119-128.
- doi: 10.4166/kjg.2017.69.2.119
BACKGROUND/AIMS: Mesenchymal stem cells (MSCs) are multipotent progenitor cells currently under investigation for its efficacy as the treatment for inflammatory bowel disease. In this study, we evaluated the efficacy of... -
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- Therapeutic effect of the immunomodulatory drug lenalidomide, but not pomalidomide, in experimental models of rheumatoid arthritis and inflammatory bowel disease
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Lopez-Millan B, Diaz de la Guardia R, Roca-Ho H, GarcÃa-Herrero CM, Lavoie JR, Rosu-Myles M, Gonzalez-Rey E, O'Valle F, Criado G, Delgado M, Menendez P
- KMID: 2375020
- Exp Mol Med.
- 2017 Feb;49(2):e290.
- doi: 10.1038/emm.2016.143
Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide... -
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- Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis
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Ryu DB, Lim JY, Lee SE, Park G, Min CK
- KMID: 2362800
- Immune Netw.
- 2016 Dec;16(6):358-365.
- doi: 10.4110/in.2016.16.6.358
Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly owing to their immunosuppressive properties. The goal of the study was to determine whether TLR ligands can... -
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- Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis
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Jeong EM, Son YH, Choi Y, Kim JH, Lee JH, Cho SY, Kim IG
- KMID: 2362291
- Exp Mol Med.
- 2016 Nov;48(11):e267.
- doi: 10.1038/emm.2016.95
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes crosslinking, polyamination or deamidation of glutamine residues in proteins. It has been reported that TG2 is involved in the pathogenesis... -
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- Fermented Pueraria Lobata extract ameliorates dextran sulfate sodium-induced colitis by reducing pro-inflammatory cytokines and recovering intestinal barrier function
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Choi S, Woo JK, Jang YS, Kang JH, Jang JE, Yi TH, Park SY, Kim SY, Yoon YS, Oh SH
- KMID: 2353590
- Lab Anim Res.
- 2016 Sep;32(3):151-159.
- doi: 10.5625/lar.2016.32.3.151
Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. In order... -
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- Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis
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Lee HJ, Oh SH, Jang HW, Kwon JH, Lee KJ, Kim CH, Park SJ, Hong SP, Cheon JH, Kim TI, Kim WH
- KMID: 2411969
- Gut Liver.
- 2016 May;10(3):412-419.
- doi: 10.5009/gnl15229
BACKGROUND/AIMS: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown beneficial effects in experimental colitis models, but the underlying mechanisms are not fully understood. We investigated the long-term effects of BM-MSCs,... -
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- Adequate Dextran Sodium Sulfate-induced Colitis Model in Mice and Effective Outcome Measurement Method
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Park YH, Kim N, Shim YK, Choi YJ, Nam RH, Choi YJ, Ham MH, Suh JH, Lee SM, Lee CM, Yoon H, Lee HS, Lee DH
- KMID: 2380878
- J Cancer Prev.
- 2015 Dec;20(4):260-267.
- doi: 10.15430/JCP.2015.20.4.260
BACKGROUND: Dextran sodium sulfate (DSS)-induced colitis mouse model is used for research of inflammatory bowel disease. The aim of this study was to establish the adequate conditions for DSS mice... -
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- Effects of natural raw meal (NRM) on high-fat diet and dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6J mice
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Shin SH, Song JL, Park MG, Park MH, Hwang SJ, Park KY
- KMID: 2313886
- Nutr Res Pract.
- 2015 Dec;9(6):619-627.
- doi: 10.4162/nrp.2015.9.6.619
BACKGROUND/OBJECTIVES: Colitis is a serious health problem, and chronic obesity is associated with the progression of colitis. The aim of this study was to determine the effects of natural raw... -
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- Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis
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Yuan B, Zhou S, Lu Y, Liu J, Jin X, Wan H, Wang F
- KMID: 2377930
- Gut Liver.
- 2015 Nov;9(6):734-740.
- doi: 10.5009/gnl14155
BACKGROUND/AIMS: This animal study aimed to define the underlying cellular mechanisms of intestinal barrier dysfunction. METHODS: Rats were fed 4% with dextran sodium sulfate (DSS) to induce experimental colitis. We analyzed... -
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- Origin of Proteinuria as Observed from Qualitative and Quantitative Analysis of Serum and Urinary Proteins
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Takahashi
- KMID: 2168404
- Child Kidney Dis.
- 2015 Oct;19(2):65-70.
- doi: 10.3339/chikd.2015.19.2.65
It is well known that proteins present in the primary urine are reabsorbed in the renal proximal tubules, and that this reabsorption is mediated via the megalincubilin complex and the... -
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- The Sasa quelpaertensis Leaf Extract Inhibits the Dextran Sulfate Sodium-induced Mouse Colitis Through Modulation of Antioxidant Enzyme Expression
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Yeom Y, Kim Y
- KMID: 2171339
- J Cancer Prev.
- 2015 Jun;20(2):136-146.
- doi: 10.15430/JCP.2015.20.2.136
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of inflammatory bowel disease. The objective of this study is to investigate the protective effect of Sasa quelpaertensis leaf extract... -
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- Alloferon Alleviates Dextran Sulfate Sodium-induced Colitis
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Kim H, Im JP, Kim JS, Kang JS, Lee WJ
- KMID: 2168039
- Immune Netw.
- 2015 Jun;15(3):135-141.
- doi: 10.4110/in.2015.15.3.135
Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a... -
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- Benzoxazole Derivative B-98 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis and the Change of T Cell Profiles in Acute Murine Colitis Model
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Song EM, Jung SA, Lee JS, Kim SE, Shim KN, Jung HK, Yoo K, Park HY
- KMID: 1711277
- Korean J Gastroenterol.
- 2013 Jul;62(1):33-41.
- doi: 10.4166/kjg.2013.62.1.33
BACKGROUND/AIMS: The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to... -
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