Korean J Hematol.
2006 Jun;41(2):129-133. 10.5045/kjh.2006.41.2.129.
CD56+ T-cell Prolymphocytic Leukemia Showing a High Expression Level of TCL1 Oncogene: A Case Report with a Review of the Literature
- Affiliations
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- 1Department of Laboratory Medicine, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Korea. mgshin@chonnam.ac.kr
- 2Genome Research Center for Hematopoietic Disease, Chonnam National University Hwasun Hospital, Korea.
- 3Department of Laboratory Medicine, Sunchon St. Carollo Hospital, Hwasun, Korea.
- KMID: 2083489
- DOI: http://doi.org/10.5045/kjh.2006.41.2.129
Abstract
- T-cell prolymphocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy with infiltration to the blood, bone marrow, lymph node, liver, spleen and skin; this disease has a poor prognosis and an aggressive clinical course. We report here on a case of CD56+ T-PLL that was diagnosed by hematological examination, immunophenotyping and molecular studies including determining the TCL1 expression by using reverse-transcriptase polymerase chain reaction (RT-PCR), and direct sequencing of the RT-PCR product.
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