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The prognostic impact of reduced variant burden in elderly patients with acute myeloid leukemia treated with decitabine

Kim M, Kim T, Ahn SY, Lee JH, Park JH, Shin MG, Jung SH, Song GY, Yang DH, Lee JJ, Choi SH, Kim MY, Ahn JS, Kim HJ, Kim DDH

Background/Aims: We evaluated the role of next-generation sequencing (NGS)-based disease monitoring for elderly patients diagnosed with acute myeloid leukemia (AML) who received decitabine therapy. Methods: A total of 123 patients aged...
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Annual Report on the External Quality Assessment Scheme for Clinical Parasitology in Korea (2020–2021)

Jeon J, Won EJ, Byeon KH, Lee YJ, Kim oJ, Shin MG, Shin JH

Annual proficiency surveys were conducted three times a year (2020–2021) by the Korean Association of External Quality Assessment Services. In addition to the image samples (MPI-20-01–MPI-20-04 and MPI-21-01–MPI-21-05), the pre-made...
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Body Fluid Analysis for Cellular Composition Using Manual Methods: Current Status and Clinical Laboratory Guidelines in Korea (2021)

Bang HI, Kim HY, Shin S, Lee JY, Kim IS, Cho YU, Kim JM, Shin MG, Lee JN, Hwang SM, Kong SY, The Committee for Standardization in Korean Society for Laboratory Hematology

To investigate the current status of body fluid analysis for cellular composition in Korea, an online survey was performed. Responses were received from 76 laboratories of general hospitals in Korea....
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Comparative evaluation of the developed targeted RNA sequencing system and a commercialized test panel

Lee YE, Park JH, Lim HJ, Kim HR, Shin JH, Shin MG

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Identification of Candida auris and Closely Related Species Using a New Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, the ASTA MicroIDSys System

Ma T, In YH, Byun SA, Lee GY, Choi MJ, Lee SY, Won EJ, Choi HJ, Choi HW, Kee SJ, Kim SH, Shin MG, Shin JH

Candida auris is a multidrug-resistant fungal pathogen emerging worldwide that is closely related to the C. haemulonii species complex. The ASTA MicroIDSys (ASTA, Korea) is a new matrix-assisted laser desorption/ionization...
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Diagnostic Accuracy and Prognostic Relevance of Immunoglobulin Heavy Chain Rearrangement and 18F-FDGPET/CT Compared With Unilateral Bone Marrow Trephination for Detecting Bone Marrow Involvement in Patients With Diffuse Large B-Cell Lymphoma

Kim M, Ahn SY, Ahn JS, Song GY, Jung SH, Lee JJ, Kim HJ, Lee JH, Shin MG, Song SY, Yang DH

Background: In diffuse large B-cell lymphoma (DLBCL), bone marrow involvement (BMI) has an important clinical implication as a component of staging and International Prognostic Index. This study aimed to determine...
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Twenty-year incidence trend of hematologic malignancies in the Republic of Korea: 1999‒2018

Park WJ, Park JH, Cho S, Shin MG

Background In this study, we presented the national cancer statistics on the incidence of hematologic malignancies in the Republic of Korea (ROK) over a period of 20 years, from 1999 to...
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A Pediatric Case of Atypical Chronic Myeloid Leukemia with CSF3R Mutation Not Responding to Ruxolitinib, but Rescued by Allogeneic Transplantation

Choi YJ, Baek HJ, Kim BR, Park SM, Shin MG, Kook H

Atypical chronic myeloid leukemia (aCML), BCR-ABL1-negative is a rare myeloid neoplasm, especially in pediatric patients. The mutations identified in aCML have overlapped with those of other myeloid neoplasms. In recent...
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The First Korean Case of NUP98-NSD1 and a Novel SNRK-ETV6 Fusion in a Pediatric Therapy-related Acute Myeloid Leukemia Patient Detected by Targeted RNA Sequencing

Lim HJ, Lee JH, Lee YE, Baek HJ, Kook H, Park JH, Lee SY, Choi HW, Choi HJ, Kee SJ, Shin JH, Shin MG

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Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia

Park MS, Lee YE, Kim HR, Shin JH, Cho HW, Lee JH, Shin MG

Phospholipase C beta 2 (PLC-β2) regulates various essential functions in cell signaling, differentiation, growth, and mobility. We investigated the clinical implications of PLC-β2 protein expression in newly diagnosed normal karyotype...
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Utility of an Automatic Vision-Based Examination System (AVE-562) for the Detection of Clonorchis sinensis Eggs in Stool

Lee YJ, Won EJ, Cho YC, Kim SH, Shin MG, Shin JH

Stool examination is the gold standard for the detection of intestinal parasites. We assessed the performance of a newly developed AVE-562 analyzer (AVE Science & Technology Co., Hunan, China) for...
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Performance Evaluation of VITEK MS for the Identification of a Wide Spectrum of Clinically Relevant Filamentous Fungi Using a Korean Collection

Shin JH, Kim SH, Lee D, Lee SY, Chun S, Lee JH, Won EJ, Choi HJ, Choi HW, Kee SJ, Shin MG, Shin JH

The correct identification of filamentous fungi is challenging. We evaluated the performance of the VITEK MS v3.0 system (bioMérieux, Marcy-l’Étoile, France) for the identification of a wide spectrum of clinically...
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Report of the Korean Association of External Quality Assessment Service on Clinical Parasitology (2018–2019)

Jeon S, Won EJ, Lee YJ, Kim MJ, Shin MG, Shin JH

Annual proficiency surveys are conducted 3 times a year (2018–2019) by the Korean Association of External Quality Assessment Service. In addition to the image samples (MPI-18-01–08; MPI-19-01–08), the pre-made slide...
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Changing the frequency and spectra of chromosomal aberrations in Korean patients with acute leukemia in a tertiary care hospital

Park JH, Kang MG, Kim HR, Lee YE, Lee JH, Choi HJ, Shin JH, Shin MG

Background Chromosomal analysis is essential for the diagnosis and risk stratification of all leukemia patients. Not surprisingly, racial differences in chromosomal aberrations (CA) in hematological malignancies could be found, and CA...
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Development and Performance Evaluation of a Quantitative Reverse Transcription PCR Kit for the Determination of prohibitin Gene Expression

Na BR, Lee YE, Kang MG, Won Y, Kim HR, Shin MG

Background: Prohibitin (PHB) regulates intracellular signal pathways, transcription, and cell cycles. Aberrant expression of the PHB gene is known to be related totumorigenesis, tumor progression, and chronic metabolic and inflammatory...
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Coronavirus disease-19 and its hematological manifestations

Kim HR, Lee YE, Kang MG, Lee SY, Lee JH, Shin MG

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Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters

Won EJ, Joo MY, Lee D, Kim MN, Park YJ, Kim SH, Shin MG, Shin JH

We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates...
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First Case of Nosocomial Fungemia Caused by Candida melibiosica

Lim HJ, Lee OJ, Kim SH, Shin MG, Shin JH

No abstract available.
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Clinical Impact of Myeloid-Derived Suppressor Cells, Lymphocyte Subsets, and Neutrophil-to-Lymphocyte Ratio in Patients with Colorectal Cancer

Kang MG, Kim CH, Kim SH, Shin JH, Kim HR, Shin MG

BACKGROUND: Preoperative myeloid-derived suppressor cells (MDSCs), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte subsets have been reported to be associated with the clinical outcomes in colorectal cancer (CRC). However, studies on the...
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Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells

Hoque MM, Lee YE, Kim HR, Shin MG

BACKGROUND: Fluoranthene (FR) is a common environmental pollutant that exists in a complex mixture with other polycyclic aromatic hydrocarbons (PAHs). We identified biomarkers for monitoring FR exposure and investigated the...
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