- Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression
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Seo D, Kim D, Kim W
- KMID: 2468862
- Genomics Inform.
- 2019 Dec;17(4):e36.
- doi: 10.5808/GI.2019.17.4.e36
The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence... -
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- KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer
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Zhou J, Chen WR, Yang LC, Wang J, Sun JY, Zhang WW, He ZY, Wu SG
- KMID: 2454312
- Cancer Res Treat.
- 2019 Jul;51(3):1207-1221.
- doi: 10.4143/crt.2018.460
PURPOSE: The study aimed to search and identify genes that were differentially expressed in breast cancer, and their roles in cancer growth and progression. MATERIALS AND METHODS: The Gene Expression Omnibus... -
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- Oncogenes, mitochondrial metabolism, and quality control in differentiated thyroid cancer
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Yi HS, Chang JY, Kim KS, Shong M
- KMID: 2411478
- Korean J Intern Med.
- 2017 Sep;32(5):780-789.
- doi: 10.3904/kjim.2016.420
Thyroid cancer is one of the most common malignancies of endocrine organs, and its incidence rate has increased steadily over the past several decades. Most differentiated thyroid tumors derived from... -
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- Pheochromocytoma Developed in a Boy with Multiple Endocrine Neoplasia Type 2A Confirmed by the RET Proto-Oncogene Mutation
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Park SY, Jin MJ, Choi EM, Kang SJ, Choi JH, Shim YJ, Kim HS, Jung EY, Lee HJ, Choi MS, Kim HW
- KMID: 2379354
- Clin Pediatr Hematol Oncol.
- 2017 Apr;24(1):75-79.
- doi: 10.15264/cpho.2017.24.1.75
A 9-year-old boy presented with increased sweating and abdominal pain. His mother and uncle had been diagnosed with bilateral pheochromocytoma and medullary thyroid carcinoma. Magnetic resonance imaging of the boy's... -
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- Characteristics of the RET Oncogene Germline Mutations in Korean Medullary Thyroid Carcinoma: A Literature Review
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Sin DJ, Min JW, Chang MC
- KMID: 2375723
- Korean J Endocr Surg.
- 2010 Jun;10(2):93-98.
- doi: 10.16956/kjes.2010.10.2.93
PURPOSE: Germline mutation of the RET oncogene results in multiple endocrine neoplasia (MEN) types 2A and 2B and familial medullary thyroid cancer (FMTC). We reviewed the literature to determine the... -
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- Medullary Thyroid Carcinoma: 25-year Experience and the Results of the RET Proto-oncogene Screening Test
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Jeong JJ, Lee YS, Kang SW, Sung TY, Lee SC, Nam KH, Chang HS, Chung WY, Park CS
- KMID: 2375753
- Korean J Endocr Surg.
- 2009 Mar;9(1):1-6.
- doi: 10.16956/kjes.2009.9.1.1
PURPOSE: Medullary thyroid carcinoma (MTC) is a rare thyroid tumor and its clinical course is quite variable. The aim of this study was to retrospectively analyze our clinical and laboratory... -
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- A Family of Multiple Endocrine Neoplasia Type 2A with a C634R Mutation and a G691S Polymorphism in RET Proto-oncogene
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Yun SW, Yoo WS, Hong KH, Kim BH, Kang MH, Choo YK, Park HY, Kim DH, Chung HK, Chang MC, Kwon MS, Kim HJ
- KMID: 1958911
- J Korean Endocr Soc.
- 2007 Dec;22(6):453-459.
- doi: 10.3803/jkes.2007.22.6.453
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant syndrome characterized by the presence of a medullary thyroid carcinoma, pheochromocytoma and hyperparathyroidism. MEN2A arises due to germline missense mutations... -
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- Amplification of the HER-2/neu Oncogene and Topoisomerase II-alpha by Chromogenic in Situ Hybridization in Breast Cancer
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Kim HS, Kim BG, Cha SJ, Lee TJ, Park SJ, Lim HM, Park SI
- KMID: 1521593
- J Korean Surg Soc.
- 2007 Aug;73(2):87-95.
PURPOSE: HER-2/neu is the most frequently amplified oncogene in breast cancer. Topoisomerase II-alpha is a key enzyme in DNA replication and it is a molecular target for many anti-cancer drugs... -
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- CD56+ T-cell Prolymphocytic Leukemia Showing a High Expression Level of TCL1 Oncogene: A Case Report with a Review of the Literature
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Yun HK, Shin MG, Kim HJ, Kim HR, Park JY, Cho D, Kee SJ, Kim YH, Shin JH, Suh SP, Ryang DW
- KMID: 2083489
- Korean J Hematol.
- 2006 Jun;41(2):129-133.
- doi: 10.5045/kjh.2006.41.2.129
T-cell prolymphocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy with infiltration to the blood, bone marrow, lymph node, liver, spleen and skin; this disease has a poor prognosis... -
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- A Case of Multiple Endocrine Neoplasia Type 2B early Diagnosis by RET Proto-oncogene Analysis and Prophylactic Total Thyroidectomy
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Kim BS, Rhie YJ, Koh H, Kim DH, Choi SH
- KMID: 1510419
- J Korean Soc Pediatr Endocrinol.
- 2006 Jun;11(1):104-109.
Multiple endocrine neoplasia type 2B (MEN 2B) is a rare autosomal-dominant hereditary syndrome which includes medullary thyroid carcinoma (MTC), pheochoromocytoma, multiple ganglioneuromas, gastrointestinal disorders and marfanoid face. MTC is the... -
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- A family of multiple endocrine neoplasia type 2A associated with a C618R mutation in RET proto-oncogene
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Kim NH, Kim JH, Nam JH, Park JP, Park JE, Choi YS, Park YH
- KMID: 1833332
- Korean J Med.
- 2006 Apr;70(4):448-454.
Medullary thyroid carcinoma (MTC) is a relatively rare malignant thyroid disease that accounts for approximately 1% to 5% of all thyroid carcinomas. MTC occurs as a sporadic disease and as... -
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- Correlation of C-erbB-2 Oncogene Amplification by Chromogenic in situ Hybridization and Expressions of Cell Cycle Regulatory Proteins in Infiltrating Duct Carcinoma of the Breast
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Park BK, Kim BG, Cha SJ, Park SJ, Lim HM, Park SI, Lee TJ
- KMID: 2210285
- J Korean Surg Soc.
- 2006 Jan;70(1):14-24.
PURPOSE: Gene amplification and/or over-expression of the c-erbB-2 are linked with poor prognosis in breast cancer. There has been only a few reports about the connection of c-erbB-2 oncogene amplification... -
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- A Case of Familial Medullary Thyroid Carcinoma with a E768D Mutation in RET Proto-Oncogene
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Kim YK, Kim JW, Ahn SM, Song KE, Jung SH, Kim DJ, Chung YS, Lee KW, Kim CH, Hong JH, Jeong SY, Kim HJ
- KMID: 2100468
- J Korean Soc Endocrinol.
- 2005 Aug;20(4):375-380.
- doi: 10.3803/jkes.2005.20.4.375
A medullary thyroid carcinoma, a neoplasm of parafollicular C cell origin, occurs as a sporadic or hereditary disease. A hereditary medullary thyroid carcinoma is an autosomal dominantly inherited disease, which... -
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- Double Minutes Containing C-MYC oncogene with a Normal Karyotype in Acute Myelogenous Leukemia: A Case Report
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Kim HS, Cho HC, Moon Y, Nahm CH, Choi JW, Yi SG, Kim SH
- KMID: 2082793
- Korean J Lab Med.
- 2005 Jun;25(3):152-154.
We report a case of a female karyotype that was normal except for double minutes (dmin) in acute myeloid leukemia. Using fluorescence in situ hybridization, the amplification of C-MYC was... -
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- Characteristics of HER-2/neu Oncogene in Korean Women with Early-onset Breast Cancer by Immunohistochemistry and Fluorescence In Situ Hybridization
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Choi DH, Lee MH, Ahn YH, Lee DW, Shin DB, Carter D, King BL, Haffty BG
- KMID: 2329036
- J Korean Breast Cancer Soc.
- 2003 Dec;6(4):255-262.
PURPOSE: The purpose of this work was to investigate the prognostic significance of of HER-2/neu (HER-2) oncogene protein overexpression in Korean women with early-onset breast cancer by immunohistochemistry. Furthermore, the... -
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- Analysis of Ret Proto-oncogene Mutation in Korean Patients with Medullary Thyroid Carcinomas
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Kim HH, Kim HJ, Chung YJ, Min YK, Lee MS, Lee MK, Kim KW, Ki CS, Kim JW, Chung JH
- KMID: 2200380
- J Korean Soc Endocrinol.
- 2003 Aug;18(4):360-370.
BACKGROUND: Medullary thyroid carcinomas (MTC) have been reported as hereditary in about 25 ~30% of cases. The identification of germline mutation in RET proto-oncogene is important in the diagnosis of... -
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- A Case of Multiple Endocrine Neoplasia Type 2B associated with a M918T Mutation in RET Proto-Oncogene
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Kim TY, Hwang JK, Moon MK, Park YJ, Park DJ, Kim SY, Lee HK, Yoon YK, Cho BY
- KMID: 2200144
- J Korean Soc Endocrinol.
- 2003 Feb;18(1):85-93.
A multiple endocrine neoplasia type 2B(MEN2B) is the most distinct and aggressive form of the MEN type 2 variants. We report a case of a 24-years-old woman with MEN2B. The... -
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- HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization and Immunohistochemical Expression of Topoisomerase II-alpha in the Breast Cancer
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Lee TJ, Oh HG, Kwon GY, Kim MK, Park ES, Yoo JH
- KMID: 1725953
- Korean J Pathol.
- 2003 Feb;37(1):26-34.
BACKGROUND: Amplifications of the HER-2/neu oncogene and the Topoisomerase II-alpha gene are important determiners of the response to chemotherapy in the breast cancer. For detecting HER-2/neu amplification, fluorescent in situ... -
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- Expression of C-MYC, C-RAS, C-ERB B-2 Oncogenes and P53 Gene in Hydatidiform Mole
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Choi HS, Kim SM, Park CS
- KMID: 1980217
- Korean J Gynecol Oncol Colposc.
- 2002 Dec;13(4):336-341.
OBJECTIVE: To date early predictors for the development of persistent gestational trophoblastic disease (PGTD) after evacuation of a complete hydatidiform mole were not known. The purpose of this study was... -
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- Change in Expression of Keratin and Proto-oncogene Induced by Beta-propiolactone in HaCaT Cell
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Liu Y, Sung EG, Song IH, Du D, Kim DK, Park JH, Sung HK, Lee Y, Kim JY
- KMID: 1559031
- Korean J Anat.
- 2001 Aug;34(4):389-404.
To investigate the relationship between the morphologic changes and the expression of keratin and proto-oncogene induced by Beta-propiolactone (BPL), we assessed on the expression of keratins (K8, K10, K13) and... -
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