Korean J Immunol.  1998 Mar;20(1):61-68.

Effect of Alcohol Administration on Production of Cytokines, Salmonella Infection and Penicillin V - Induced Anaphylaxis in Mice

• Ha TY
• Park JS
• Lee BY
• Ha HJ

Abstract

The present study was undertaken to investigate the effect of acute administration of ethanol on production of cytokines such as IL-1j3, IL-2, IL-6, IL-10 and TNF-a, induction of penicillin V-induced active fatal anaphylaxis, and resistence to Salmonel/a typhimurium infection in mice. Ethanol administration into mice was performed by intraperitoneal injection of 0.5 ml of 20 % ethanol for 3 consecutive days before induction of cytokines with lipopolysaccharide (LPS), Con A or Salmone/la injection. Serum levels of cytokines were measured by ELISA. It was found that ethanol administration significantly inhibited both the serum levels of all cytokines examined and the resistance of mice to S. typhimurium. However, ethanol administration failed to prevent penicillin-induced fatal anaphylaxis. Taken together, the present results may need new insights in the diagnosis and treatment of various immunologically-mediated diseases.

Keyword

Alcohol; Interleukin; TNF-a; Salmonella infection; Anaphylaxis

MeSH Terms

Anaphylaxis*
Animals
Cytokines*
Diagnosis
Enzyme-Linked Immunosorbent Assay
Ethanol
Injections, Intraperitoneal
Interleukin-10
Interleukin-2
Interleukin-6
Interleukins
Mice*
Penicillin V*
Penicillins*
Salmonella Infections*
Salmonella*
Cytokines
Ethanol
Interleukin-10
Interleukin-2
Interleukin-6
Interleukins
Penicillin V
Penicillins