- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C
- KMID: 2470964
- Diabetes Metab J.
- 2020 Feb;44(1):158-172.
- doi: 10.4093/dmj.2018.0235
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated... -
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- High-definition ultrasound characterization of acute cyclophosphamide-induced cystitis in the mouse
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Lee TG, Sanderson , Doyle P, Li D, Wood RW
- KMID: 2466795
- Investig Clin Urol.
- 2020 Jan;61(1):75-80.
- doi: 10.4111/icu.2020.61.1.75
PURPOSE: To examine associations if any between changes in voiding function, hematuria, and bladder ultrasonography metrics in murine cyclophosphamide-induced chemical cystitis. MATERIALS AND METHODS: Cystitis was induced in 6 female mice... -
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- Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus
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Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW
- KMID: 2470012
- Lab Anim Res.
- 2019 Dec;35(4):154-164.
- doi: 10.1186/s42826-019-0020-2
In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into... -
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- Docosahexaenoic Acid Inhibits Expression of Fibrotic Mediators in Mice With Chronic Pancreatitis
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Lee S, Jeong YK, Lim JW, Kim H
- KMID: 2468813
- J Cancer Prev.
- 2019 Dec;24(4):233-239.
- doi: 10.15430/JCP.2019.24.4.233
BACKGROUND: Chronic pancreatitis (CP) is an irreversible progressive disease that destroys exocrine parenchyma, which are replaced by fibrous tissue. As pancreatic fibrosis is a key feature of CP, reducing fibrotic... -
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- Cardioprotective Potential of an SGLT2 Inhibitor Against Doxorubicin-Induced Heart Failure
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Oh CM, Cho S, Jang JY, Kim H, Chun S, Choi M, Park S, Ko YG
- KMID: 2464299
- Korean Circ J.
- 2019 Dec;49(12):1183-1195.
- doi: 10.4070/kcj.2019.0180
BACKGROUND AND OBJECTIVES: Recent studies have shown that sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of heart failure (HF)-associated hospitalization and mortality in patients with diabetes. However, it is... -
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- Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-induced hepatitic ICR mice
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Park CM, Song YS
- KMID: 2464126
- Nutr Res Pract.
- 2019 Dec;13(6):473-479.
- doi: 10.4162/nrp.2019.13.6.473
BACKGROUND/OBJECTIVES: Anti-inflammatory and antioxidative activities of luteolin and luteolin-7-O-glucoside were compared in galactosamine (GalN)/lipopolysaccharide (LPS)-induced hepatitic ICR mice. MATERIALS/METHODS: Male ICR mice (6 weeks old) were divided into 4 groups: normal... -
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- Lipopolysaccharide induces neuroglia activation and NF-κB activation in cerebral cortex of adult mice
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Kang JB, Park DJ, Shah MA, Kim MO, Koh PO
- KMID: 2470009
- Lab Anim Res.
- 2019 Oct;35(3):132-139.
- doi: 10.1186/s42826-019-0018-9
Lipopolysaccharide (LPS) acts as an endotoxin, releases inflammatory cytokines, and promotes an inflammatory response in various tissues. This study investigated whether LPS modulates neuroglia activation and nuclear factor kappa B... -
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- Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources
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Jeong TB, Kim JH, Kim SH, Lee S, Son SW, Lim Y, Cho JY, Hwang DY, Kim KS, Kwak JH, Jung YS
- KMID: 2470006
- Lab Anim Res.
- 2019 Oct;35(3):107-113.
- doi: 10.1186/s42826-019-0017-x
Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic dosage, APAP is mainly... -
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- Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated with NLRP3 inflammasome in alloxan-induced diabetic mice
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Lee H, Lim Y
- KMID: 2464116
- Nutr Res Pract.
- 2019 Oct;13(5):377-383.
- doi: 10.4162/nrp.2019.13.5.377
BACKGROUND/OBJECTIVES: Hyperglycemia-induced hepatic damage has been recognized as one of the major cause of complications in diabetes. Hepatic complications are associated with inflammation and oxidative stress in diabetes. In this... -
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- Autophagy localization and cytoprotective role in cisplatin-induced acute kidney injury
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- KMID: 2461010
- Korean J Vet Res.
- 2019 Sep;59(3):133-139.
- doi: 10.14405/kjvr.2019.59.3.133
Autophagy is a fundamental cellular process that maintains homeostasis and cell integrity, under stress conditions. Although the involvement of autophagy in various conditions has been elucidated, the role of autophagy... -
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- Aged mice show an increased mortality after anesthesia with a standard dose of ketamine/xylazine
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Schuetze S, Manig A, Ribes S, Nau R
- KMID: 2470107
- Lab Anim Res.
- 2019 Aug;35(2):45-51.
- doi: 10.1186/s42826-019-0008-y
Geriatric animal models are crucial for a better understanding and an improved therapy of age-related diseases. We observed a high mortality of aged mice after anesthesia with a standard dose... -
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- Synergistic effects of extracorporeal shockwave therapy and modified Ojayeonjonghwan on erectile dysfunction in an animal model of diabetes
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Jeong HC, Bae WJ, Zhu GQ, Jeon SH, Choi SW, Kim SJ, Cho HJ, Hong SH, Lee JY, Hwang SY, Kim SW
- KMID: 2450546
- Investig Clin Urol.
- 2019 Jul;60(4):285-294.
- doi: 10.4111/icu.2019.60.4.285
PURPOSE: We investigated the synergy effect of extracorporeal shock wave therapy (ESWT) with modified Ojayeonjonghwan (Korean herbal formula, KH-204) in an animal model of diabetes mellitus (DM)-induced erectile dysfunction (ED). MATERIALS... -
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- Pharmacokinetics of cisplatin during open and minimally-invasive secondary cytoreductive surgery plus HIPEC in women with platinum-sensitive recurrent ovarian cancer: a prospective study
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Petrillo M, Zucchetti , Cianci S, Morosi L, Ronsini C, Colombo A, D'Incalci , Scambia G, Fagotti A
- KMID: 2450238
- J Gynecol Oncol.
- 2019 Jul;30(4):e59.
- doi: 10.3802/jgo.2019.30.e59
OBJECTIVE: Evidences from animal models seem to suggest that minimally invasive surgery may enhance cisplatin diffusion when the drug is administered in the context of post-operative hyperthermic intraperitoneal chemotherapy (HIPEC).... -
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- The effect of alpha-lipoic acid on expression of VCAM-1 in type 2 diabetic rat
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Ismawati , Mukhyarjon , Asni E, Romus I
- KMID: 2451221
- Anat Cell Biol.
- 2019 Jun;52(2):176-182.
- doi: 10.5115/acb.2019.52.2.176
Macrovascular diabetes complications are generally caused by a process called atherosclerosis. Evidences suggest that to initiate atherosclerosis, oxidated low-density lipoprotein (oxLDL) has to promote the expression of adhesion molecule. Several... -
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- Fumigaclavine C attenuates adipogenesis in 3T3-L1 adipocytes and ameliorates lipid accumulation in high-fat diet-induced obese mice
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Yu WG, He Y, Chen YF, Gao XY, Ning WE, Liu CY, Tang TF, Liu Q, Huang XC
- KMID: 2443604
- Korean J Physiol Pharmacol.
- 2019 May;23(3):161-169.
- doi: 10.4196/kjpp.2019.23.3.161
Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether... -
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- Analgesic effects of eucalyptus essential oil in mice
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Lee G, Park J, Kim MS, Seol GH, Min SS
- KMID: 2449820
- Korean J Pain.
- 2019 Apr;32(2):79-86.
- doi: 10.3344/kjp.2019.32.2.79
BACKGROUND: The use of aroma oils dates back to at least 3000 B.C., where it was applied to mummify corpses and treat the wounds of soldiers. Since the 1920s, the... -
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- Induction of Angiogenesis by Malarial Infection through Hypoxia Dependent Manner
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Park MK, Ko EJ, Jeon KY, Kim H, Jo JO, Baek KW, Kang YJ, Choi YH, Hong Y, Ock MS, Cha HJ
- KMID: 2448142
- Korean J Parasitol.
- 2019 Apr;57(2):117-125.
- doi: 10.3347/kjp.2019.57.2.117
Malarial infection induces tissue hypoxia in the host through destruction of red blood cells. Tissue hypoxia in malarial infection may increase the activity of HIF1α through an intracellular oxygen-sensing pathway.... -
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- Adjunctive Lurasidone Suppresses Food Intake and Weight Gain Associated with Olanzapine Administration in Rats
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Reynolds G, Dalton CF, Watrimez W, Jackson J, Harte MK
- KMID: 2456735
- Clin Psychopharmacol Neurosci.
- 2019 Mar;17(2):314-317.
- doi: 10.9758/cpn.2019.17.2.314
OBJECTIVE: Lurasidone is an antipsychotic drug that shows a relative lack of weight gain common to many antipsychotics. Aripiprazole and ziprasidone also show little weight gain and can reduce olanzapine-induced... -
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- Effects of Intraperitoneal N-methyl-D-aspartate (NMDA) Administration on Nociceptive/Repetitive Behaviors in Juvenile Mice
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Kim S, Kim DG, Gonzales E, Mabunga DF, Shin D, Jeon SJ, Shin CY, Ahn T, Kwon KJ
- KMID: 2442008
- Biomol Ther.
- 2019 Feb;27(2):168-177.
- doi: 10.4062/biomolther.2018.230
Dysregulation of excitatory neurotransmission has been implicated in the pathogenesis of neuropsychiatric disorders. Pharmacological inhibition of N-methyl-D-aspartate (NMDA) receptors is widely used to model neurobehavioral pathologies and underlying mechanisms. There... -
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- Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice
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Kee HJ, Ryu Y, Seok YM, Choi SY, Sun S, Kim GR, Jeong MH
- KMID: 2468620
- Clin Hypertens.
- 2019 ;25(1):13.
- doi: 10.1186/s40885-019-0118-8
BACKGROUND: The dysregulation of histone deacetylase (HDAC) protein expression or its enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme activity induced by deoxycorticosterone acetate... -
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