- Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression
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Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q
- KMID: 2471035
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):137-147.
- doi: 10.4196/kjpp.2020.24.2.137
Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis... -
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- Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies
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Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S
- KMID: 2467417
- Asian Spine J.
- 2019 Dec;13(6):875-889.
- doi: 10.31616/asj.2019.0073
STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against... -
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- Bowel Wall Thickness, Elasticity, Intestinal Permeability, and Inflammatory Cytokines in Patients with Cirrhosis and Ascites
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Lee SH, Kwon HJ, Kim NH, Kim HJ, Cho YK, Jeon WK, Park EH, Kim BI
- KMID: 2467217
- Korean J Med.
- 2019 Dec;94(6):511-518.
- doi: 10.3904/kjm.2019.94.6.511
BACKGROUND/AIMS: Previous studies have reported that endotoxemia is associated with pathogenesis and complications in cirrhosis. Endotoxin stimulates the secretion of inflammatory cytokines, which contributes to the development of complications. In... -
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- Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells
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Kim JE, Sharma A, Sharma G, Lee SY, Shin HS, Rudra D, Im SH
- KMID: 2466609
- Immune Netw.
- 2019 Dec;19(6):e39.
- doi: 10.4110/in.2019.19.e39
Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify... -
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- Immunosuppressive Effect of Exosomes from Mesenchymal Stromal Cells in Defined Medium on Experimental Colitis
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Ma ZJ, Wang YH, Li ZG, Wang Y, Li BY, Kang HY, Wu XY
- KMID: 2465884
- Int J Stem Cells.
- 2019 Nov;12(3):440-448.
- doi: 10.15283/ijsc18139
BACKGROUND AND OBJECTIVES: The exosomes released by mesenchymal stromal cells (MSCs) in classical FBS-containing media have been demonstrated as an alternative, cell-free therapy in various diseases including inflammatory bowel disease... -
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- Hyaluronic acid has chondroprotective and joint-preserving effects on LPS-induced synovitis in horses
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Neuenschwander HM, Moreira JJ, Vendruscolo CP, Fülber J, Seidel SR, Michelacci YM, Baccarin R
- KMID: 2464083
- J Vet Sci.
- 2019 Nov;20(6):e67.
- doi: 10.4142/jvs.2019.20.e67
The intra-articular use of hyaluronic acid (HA) for the treatment of synovitis and osteoarthritis is still controversial. As a consequence, corticosteroids remain the most frequently employed therapeutic agents, despite their... -
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- Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice
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Cao W, Mo K, Wei S, Lan X, Zhang W, Jiang W
- KMID: 2461043
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):501-508.
- doi: 10.4196/kjpp.2019.23.6.501
Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular... -
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- Comparison of responsiveness to cancer development and anti-cancer drug in three different C57BL/6N stocks
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Kang MJ, Kim JE, Park JW, Choi HJ, Bae SJ, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK
- KMID: 2470007
- Lab Anim Res.
- 2019 Oct;35(3):114-123.
- doi: 10.1186/s42826-019-0015-z
In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies.... -
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- Brown Adipocyte and Splenocyte Co-Culture Maintains Regulatory T Cell Subset in Intermittent Hypobaric Conditions
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Kang TH, Park JH, Shin D, Choi H, Kim J, Lee MC
- KMID: 2464073
- Tissue Eng Regen Med.
- 2019 Oct;16(5):539-548.
- doi: 10.1007/s13770-019-00205-y
BACKGROUND: Brown adipocytes have thermogenic characteristics in neonates and elicit anti-inflammatory responses. We postulated that thermogenic brown adipocytes produce distinctive intercellular effects in a hypobaric state. The purpose of this... -
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- Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth
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Kim D, Koh J, Ko JS, Kim HY, Lee H, Chung DH
- KMID: 2461196
- Immune Netw.
- 2019 Oct;19(5):e32.
- doi: 10.4110/in.2019.19.e32
Pellino-1 is a ubiquitin (Ub) E3 ligase that plays a role in M1, but not M2a polarization of macrophages. However, it is unknown whether Pellino-1 regulates IL-10-mediated M2c polarization of... -
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- Sex-related Alterations of Gut Microbiota in the C57BL/6 Mouse Model of Inflammatory Bowel Disease
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Son HJ, Kim N, Song CH, Nam RH, Choi SI, Kim JS, Lee DH
- KMID: 2468799
- J Cancer Prev.
- 2019 Sep;24(3):173-182.
- doi: 10.15430/JCP.2019.24.3.173
BACKGROUND: Gut microbiota is closely associated with development and exacerbation of inflammatory bowel diseases (IBD). The aim of this study was to investigate differences in gut microbiota depending on sex... -
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- Short-term Haze Exposure Predisposes Healthy Volunteers to Nasal Inflammation
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Xian M, Wang K, Lou H, Wang Y, Zhang L, Wang C
- KMID: 2452754
- Allergy Asthma Immunol Res.
- 2019 Sep;11(5):632-643.
- doi: 10.4168/aair.2019.11.5.632
PURPOSE: This study aimed to investigate the impact of short-term haze exposure on nasal inflammation in healthy volunteers. METHODS: Thirty-three healthy university students were assessed for nasal symptoms, nasal patency, upper... -
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- Antileishmanial Activity of Niosomal Combination Forms of Tioxolone along with Benzoxonium Chloride against Leishmania tropica
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Parizi MH, Farajzadeh S, Sharifi I, Pardakhty , Parizi MH, Sharifi H, Salarkia E, Hassanzadeh S
- KMID: 2459473
- Korean J Parasitol.
- 2019 Aug;57(4):359-368.
- doi: 10.3347/kjp.2019.57.4.359
In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with benzoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by... -
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- Distinct Inflammation Biomarkers in Healthy Individuals and Patients with Schizophrenia: A Reliability Testing of Multiplex Cytokine Immunoassay by Bland-Altman Analysis
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Yeh TC, Chu HT, Tsai CK, Chang HA, Yang FC, Huang SY, Liang CS
- KMID: 2456171
- Psychiatry Investig.
- 2019 Aug;16(8):607-614.
- doi: 10.30773/pi.2019.04.14
OBJECTIVE: Since the inflammatory process has been implicated in the pathophysiology of psychiatric disorder, an important issue emerging is to assess the test-retest reliability of cytokine measurement in healthy individuals... -
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- Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease
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Zhou L, Liu D, Xie Y, Yao X, Li Y
- KMID: 2458527
- Gut Liver.
- 2019 Jul;13(4):430-439.
- doi: 10.5009/gnl18316
BACKGROUND/AIMS: The current study aims to investigate the protective effects of Bifidobacterium infantis on the abnormal immune response to inflammatory bowel disease (IBD) in dextran sodium sulfate (DSS)-induced colitis. METHODS: Eight-week-old... -
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- Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps
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Zhang Y, Lou H, Wang Y, Li Y, Zhang L, Wang C
- KMID: 2448751
- Allergy Asthma Immunol Res.
- 2019 Jul;11(4):482-497.
- doi: 10.4168/aair.2019.11.4.482
PURPOSE: Corticosteroids are regarded as the mainstay of medical treatment of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To date, a head-to-head comparison of the efficacy and safety of glucocorticoid... -
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- Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus
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Choi J, Choi SA, Kim SY, Kim H, Lim BC, Hwang H, Chae JH, Kim KJ, Oh S, Shin JS
- KMID: 2453789
- Ann Child Neurol.
- 2019 Jun;27(2):38-45.
- doi: 10.26815/acn.2019.00038
PURPOSE: Cytokines demonstrate active roles in the occurrence of febrile seizures (FS). However, whether a genetic predisposition to inflammation is implicated in FS, febrile seizure plus (FS+) or genetic epilepsy... -
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- Association of Tumor Necrosis Factor-α Gene Promotor Variant, Not Interleukin-10, with Febrile Seizures and Genetic Epilepsy with Febrile Seizure Plus
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Choi J, Choi SA, Kim SY, Kim H, Lim BC, Hwang H, Chae JH, Kim KJ, Oh S, Shin JS
- KMID: 2452693
- J Korean Child Neurol Soc.
- 2019 Jun;27(2):38-45.
- doi: 10.26815/acn.2019.00038
PURPOSE: Cytokines demonstrate active roles in the occurrence of febrile seizures (FS). However, whether a genetic predisposition to inflammation is implicated in FS, febrile seizure plus (FS+) or genetic epilepsy... -
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- Mitigation effects of red Platycodon grandiflorum extract on lipopolysaccharide-induced inflammation in splenocytes isolated from mice
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Park EJ, Lee YS, Jeong HC, Lee SH, Lee HJ
- KMID: 2450421
- J Nutr Health.
- 2019 Jun;52(3):243-249.
- doi: 10.4163/jnh.2019.52.3.243
PURPOSE: Platycodon grandiflorum (PG) is known to have effective antimicrobial and anticancer activity. The main bioactive components of PG are saponins, and these could contribute to anti-inflammatory activity. However, little... -
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- Prominent Inflammatory Features of Monocytes/Macrophages in Acute Calcium Pyrophosphate Crystal Arthritis: a Comparison with Acute Gouty Arthritis
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Jeong JH, Jung JH, Lee JS, Oh JS, Kim YG, Lee CK, Yoo B, Hong S
- KMID: 2450206
- Immune Netw.
- 2019 Jun;19(3):e21.
- doi: 10.4110/in.2019.19.e21
Calcium pyrophosphate (CPP) crystals can present as acute inflammatory arthritis which is known as an acute CPP crystal arthritis. Although monocytes/macrophages have been shown to play a role in the... -
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