Korean J Leg Med.  2009 May;33(1):53-56.

An Autopsy Case of Alzheimer's Disease

Affiliations
  • 1Division of Forensic Medicine, National Institute of Scientific Investigation, Seoul, Korea. tjkwon@nisi.go.kr

Abstract

Alzheimer's disease is the leading cause of dementia. We experienced a case of Alzheimer's disease who is 83-year-old woman killed by stab with a knife. She had been suffered from dementia for several years. At autopsy, the brain disclosed cortical atrophy in the frontal, temporal and parietal lobes, and hippocampus. Microscopically, many senile plaques and a few neurofibrillary tangles were observed at the cerebral cortex and hippocampus. Senile plaques were characterized by a spherical structure with or without a dense central core of amyloid, associated with dystrophic neurites. Neurofibrillary tangle was an intracellular filamentous lesion in the cell body of neuron. To our knowledge, this is a rare autopsy case in Korea, therefore, we report here-in and review the clinicopathologic features of Alzheimer's disease.

Keyword

Alzheimer's disease; dementia; pathology
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