- Expression of Major Gangliosides in Normal and Alzheimer Disease Brain
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Lee MC, Woo YJ, Kim SU, Tai T
- KMID: 1725940
- Korean J Pathol.
- 2002 Dec;36(6):400-405.
BACKGROUND: GM1 ganglioside-bound amyloid beta-protein (GM1/A) has been reported to be involved with senile plaque formation in Alzheimer disease. METHODS: To investigate the binding of major gangliosides on senile plaques and... -
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- Drug Development for Alzheimer's Disease: Recent Progress
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Ji W, Ha I
- KMID: 1460756
- Exp Neurobiol.
- 2010 Dec;19(3):120-131.
- doi: 10.5607/en.2010.19.3.120
Alzheimer's disease, the most common cause of dementia, is characterized by two major pathological hallmarks: amyloid plaques and neurofibrillary tangles. Based on these two indicators, an amyloid cascade hypothesis was... -
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- Animal Models of Alzheimer's Dementia
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Woo SI
- KMID: 2334613
- J Korean Soc Biol Psychiatry.
- 1999 Nov;6(2):149-152.
Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and... -
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- An Autopsy Case of Alzheimer's Disease
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Kwon T, Wona YJ, Lee JS, Ha H
- KMID: 2082727
- Korean J Leg Med.
- 2009 May;33(1):53-56.
Alzheimer's disease is the leading cause of dementia. We experienced a case of Alzheimer's disease who is 83-year-old woman killed by stab with a knife. She had been suffered from... -
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- Alzheimer's Disease: Report of two cases
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Kim HS, Suh YL, Hong KS, Na DL
- KMID: 1725220
- Korean J Pathol.
- 1997 Feb;31(2):167-173.
Alzheimer's disease (AD) is the most common etiology of dementia, that has not been previously reported in Korea. We have experienced two cases of Alzheimer's disease, one occurred in... -
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- Prospect of Geriatric Psychiatric Research: Research on Alzheimer's Disease
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Kim SH, Lee HJ
- KMID: 2340752
- J Korean Neuropsychiatr Assoc.
- 2002 Sep;41(5):767-777.
Alzheimer's disease(AD) is a progressive dementia characterized by global cognitive decline and is defined pathologically by amyloid plaques and neurofibrillary tangles. In the past 10 years, important progress has been... -
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- Pathogenesis of Alzheimer's Dementia
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Suh YH
- KMID: 2184701
- J Korean Med Assoc.
- 2006 Aug;49(8):717-730.
- doi: 10.5124/jkma.2006.49.8.717
Alzhelmer's disease (AD) is the most common cause of dementia that arises on a neuropathological background of amyloid plaques containing betaamylold (Abeta) derived from amyloid precursor protein (APP) and tau-rich... -
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- Animal Models of Dementia
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Choi DH, Lee J
- KMID: 1445605
- Brain Neurorehabil.
- 2011 Mar;4(1):21-29.
- doi: 10.12786/bn.2011.4.1.21
The discovery of new therapies for neurological disorders is especially predicated on the use of animal models both to identify new therapeutic targets and to carry out preclinical drug trials.... -
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- Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies
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Choi Y, Ha S, Lee YS, Kim YK, Lee DS, Kim DJ
- KMID: 2407298
- Nucl Med Mol Imaging.
- 2018 Feb;52(1):24-30.
- doi: 10.1007/s13139-017-0484-7
The pathological features of Alzheimer's disease are senile plaques which are aggregates of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and... -
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- A Case Report of Progressive Subcortical Gliosis
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Kim SY, La DL, Park SH, Koo HS, Chi JG
- KMID: 1957249
- J Korean Neurol Assoc.
- 1995 Sep;13(3):696-702.
A patient presenting with the characteristic clinical features of the dementia of Pick's type is described, in whom neuropathological examination of brain biopsy material revealed atypical features, including extensive subcotical... -
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- Novel Pharmacotherapies for Alzheimer's Disease
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Han SH
- KMID: 2188088
- J Korean Med Assoc.
- 2009 Nov;52(11):1059-1068.
- doi: 10.5124/jkma.2009.52.11.1059
Alzheimer disease (AD) is pathologically characterized by extracellular amyloid deposits composed of beta-amyloid (A beta) peptide, neurofibrillary tangles (NFTs) made up of hyperphosphorylated tau, and deficit of cholinergic neurons in... -
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- Clinical and Pathological Characteristics of Frontotemporal Lobar Degeneration(FTLD) and Molecular Genetics of Tau Protein
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Woo SI
- KMID: 2202778
- J Korean Soc Biol Psychiatry.
- 2003 Nov;10(2):97-106.
Criticisms about amyloid cascade hypothesis of Alzheimer's disease(AD) are based on the findings, first, that the degree of dementia does not correlate with the number of plaques, and second, that... -
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- Biomarkers Predicting Alzheimer's Disease in Cognitively Normal Aging
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Shim YS, Morris JC
- KMID: 2178968
- J Clin Neurol.
- 2011 Jun;7(2):60-68.
- doi: 10.3988/jcn.2011.7.2.60
The pathophysiologic process of Alzheimer's disease (AD) begins years before the diagnosis of clinical dementia. This concept of preclinical AD has arisen from the observation of AD pathologic findings such... -
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- A Newer Therapeutic Strategies For Alzheimer's Disease
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Han SH
- KMID: 2185998
- J Korean Neurol Assoc.
- 2001 Nov;19(6):559-565.
Alzheimer's disease (AD) is characterized pathologically by cholinergic deficits, extracelluar amyloid deposit, intra-neuronal neurofibrillary tangles, gliosis and neuronal and synaptic loss. The primary therapeutic approach has been cholinergic augumentation by... -
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- Molecular Genetic Aspects of Alzheimer's Disease
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Han SH
- KMID: 2416590
- J Korean Med Assoc.
- 2002 Apr;45(4):378-384.
- doi: 10.5124/jkma.2002.45.4.378
Alzheimer's disease (AD), the cause of one of the most common types of dementia, is pathologically characterized by cholinergic deficits, extracellular amyloid deposit, intraneuronal neurofibrillary tangles, gliosis, and neuronal and... -
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- Pathogenic Mechanism of Alzheimer's Disease
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Han SH
- KMID: 2053696
- Hanyang Med Rev.
- 2006 Feb;26(1):4-13.
Alzheimer's disease (AD) is regarded as a prototype of the neurodegenerative disorder characterized by progressive memory impairment and multiple cognitive deficits in mid- to late- life. Its pathological hallmarks consist... -
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- Neurotoxic Effect of beta-Amyloid Peptide in Hippocampal Slice Culture
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Park JS, Jo MS, Jung YJ, Lee KE
- KMID: 2352867
- Ewha Med J.
- 2003 Jun;26(2):143-148.
- doi: 10.12771/emj.2003.26.2.143
Alzheimer's disease(AD) is primarily characterized by neurofibrillary tangles, senile plaques, and neurodegeneration. The major component of senile plaques is the beta-amyloid peptide(A beta), Which is considered to have a causal... -
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- Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy
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Kim D, Kim HS, Choi SM, Kim BC, Lee MC, Lee KH, Lee JH
- KMID: 2449338
- J Pathol Transl Med.
- 2019 May;53(3):159-163.
- doi: 10.4132/jptm.2019.03.14
Due to the progressive aging of Korean society and the introduction of brain banks to the Korean medical system, the possibility that pathologists will have access to healthy elderly brains... -
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- Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau
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Kim SI, Lee WK, Kang SS, Lee SY, Jeong MJ, Lee HJ, Kim SS, Johnson GV, Chun W
- KMID: 2285415
- Korean J Physiol Pharmacol.
- 2011 Apr;15(2):107-114.
- doi: 10.4196/kjpp.2011.15.2.107
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3beta has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate... -
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- Stem Cell Therapy: A Prospective Treatment for Alzheimer's Disease
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Lee JH, Oh IH, Lim HK
- KMID: 2360373
- Psychiatry Investig.
- 2016 Nov;13(6):583-589.
- doi: 10.4306/pi.2016.13.6.583
Alzheimer's disease (AD) without cure remains as a serious health issue in the modern society. The major neuropathological alterations in AD are characterized by chronic neuroinflammation and neuronal loss due... -
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