Korean J Otolaryngol-Head Neck Surg.
1997 May;40(5):719-724.
Expression of Transforming Growth Factor-Beta(TGF-beta) in Middle Ear Cholesteatoma
- Affiliations
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- 1Department of Otolaryngology, Pediatrics, Catholic University Medical College, Seoul, Korea.
- 2Department of Pediatrics, Catholic University Medical College, Seoul, Korea.
Abstract
- The role of transforming growth factor-beta(TGF-beta) in the proliferation and progression of the epithelium of middle ear cholesteatoma was studied. We eluciated the site and degree of expression of the TGF-beta mRNA in middle ear choleasteatoma using in situ hybridization method and compared with that in epidermis of external auditory canal skin, cholesterol granuloma and cervical lymph node. TGF-beta mRNA was intensely expressed in lymphatic cells of cervical lymph nodes while canal skin and cholesterol granuloma did not express TGF-beta mRNA. Expression of TGF-beta mRNA was detected in the basal layer of epithelium of cholesteatoma in 12(83%) and in all layer of epithelium of cholesteatoma in 7(50%) of 14 samples even though it was more intense in the basal layer of epithelium. The results of the present study suggest that TGF-beta may play a role of immunoregulator in a mechanism of epithelial basal cell proliferation in middle ear cholesteatoma.
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