Anesth Pain Med.
2008 Oct;3(4):277-281.
The effect of vitamin C on hemodynamics and arterial blood gas in tourniquet induced ischemia-reperfusion injury during unilateral total knee replacement in elderly patients
- Affiliations
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- 1Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. jhjs0806@catholic.ac.kr
Abstract
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BACKGROUND: Free radicals, such as reactive oxygen species which are released abruptly after deflation of an ischemic tourniquet, cause reperfusion injuries. Vitamin C produce cytoprotective effects due to reduction of free radicals. This study was designed to investigate the effect of vitamin C on hemodynamics and arterial blood gas during unilateral total knee replacement.
METHODS
In the vitamin C group (VC group: N = 19), patients were administrated with vitamin C:a priming bolus of vitamin C 0.06 g/kg mixed with 100 ml saline infused for 20 min at 10 min before deflation of tourniquet, followed by vitamin C 0.02 g/kg mixed with 30 ml saline at 0.5 ml/min. In the control group (control group: N = 15), patients were infused by 100 ml saline. Mean arterial blood pressure, heart rate and arterial blood gas were measured at 20 min after anesthesia induction, just before deflation, 5 min after deflation and 20 min after deflation of tourniquet.
RESULTS
Mean arterial blood pressure in the VC group was maintained higher than control group at 1 min after deflation of the tourniquet. Arterial O2 tension and saturation in the VC group were higher than control group at 5 min and 20 min after deflation of the tourniquet.
CONCLUSIONS
We concluded that the administration of vitamin C during total knee replacement could inhibit decline of mean arterial blood pressure and arterial oxygenation induced by ischemiareperfusion significantly.
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