- Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate
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Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ
- KMID: 2471036
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):149-156.
- doi: 10.4196/kjpp.2020.24.2.149
Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS... -
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- Mitochondrial Mechanisms in Diabetic Cardiomyopathy
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Gollmer J, Zirlik A, Bugger H
- KMID: 2470953
- Diabetes Metab J.
- 2020 Feb;44(1):33-53.
- doi: 10.4093/dmj.2019.0185
Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus... -
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- Neuroprotective effects of urolithin A on Hâ‚‚Oâ‚‚-induced oxidative stress-mediated apoptosis in SK-N-MC cells
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Kim KB, Lee S, Kim JH
- KMID: 2468507
- Nutr Res Pract.
- 2020 Feb;14(1):3-11.
- doi: 10.4162/nrp.2020.14.1.3
BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high... -
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- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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- Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells
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Hwang S, Kim JK
- KMID: 2468142
- Chonnam Med J.
- 2020 Jan;56(1):20-26.
- doi: 10.4068/cmj.2020.56.1.20
We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours... -
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- Anti-tumor activity and mitochondrial stability of disulfiram in HL-60 cells
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- KMID: 2470118
- Korean J Vet Res.
- 2019 Dec;59(4):195-199.
- doi: 10.14405/kjvr.2019.59.4.195
Disulfiram (DSF) is a member of the dithiocarbamate family that can bind copper. Recent studies have shown that DSF has anti-cancer activities, but the mechanism has not been clarified. Therefore,... -
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- Protective effects of D-005, a lipid extract from Acrocomia crispa fruits, against ischemia/reperfusion-induced acute kidney injury in rats
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Oyarzábal-Yera A, RodrÃguez-Salgueiro S, Merino-GarcÃa N, Ocaña-Nápoles L, González-Núñez L, Mena-Valdés L, Zamora-RodrÃguez Z, Medina-PÃrez JA, Jiménez-Despaigne S, Molina-Cuevas V
- KMID: 2469376
- Kidney Res Clin Pract.
- 2019 Dec;38(4):462-471.
- doi: 10.23876/j.krcp.19.053
BACKGROUND: Acute kidney injury (AKI) induced by renal ischemia/reperfusion (IR) is associated with enhanced production of reactive oxygen species in renal tissues. D-005, a lipid extract obtained from Acrocomia crispa... -
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- The role of oxidative stress and hypoxia in renal disease
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Honda T, Hirakawa Y, Nangaku M
- KMID: 2469372
- Kidney Res Clin Pract.
- 2019 Dec;38(4):414-426.
- doi: 10.23876/j.krcp.19.063
Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial oxygen consumption for energy production. Any imbalance between ROS production and its scavenger system... -
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- Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target
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Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ
- KMID: 2468809
- J Cancer Prev.
- 2019 Dec;24(4):197-207.
- doi: 10.15430/JCP.2019.24.4.197
BACKGROUND: BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and the higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive... -
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- Aralia cordata Extract Activates NF-κB and MAPK Signaling Pathways and Induces Pro-inflammatory Changes in RAW264.7 Macrophages
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Seo DW, Cho YI, Yi YJ, Lee SM
- KMID: 2468022
- J Bacteriol Virol.
- 2019 Dec;49(4):153-161.
- doi: 10.4167/jbv.2019.49.4.153
Macrophages play essential roles in innate immune responses by producing various immune mediators. Therefore, modulating macrophage function is an attractive strategy to treat immune disorders. Aralia cordata var. continentalis (AC),... -
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- Regulatory Pathway of Ion-Transporter Genes through Nrf2 Transcription Factor in Hypokalemic Condition
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Cho HJ, Ahn KY
- KMID: 2467467
- Anat Biol Anthropol.
- 2019 Dec;32(4):141-149.
- doi: 10.11637/aba.2019.32.4.141
The Nuclear factor-erythroid-2-related factor 2 (Nrf2) plays a key role in the cellular defense against oxidative stress. Low K+ increased the reactive oxygen species and it stimulate Nrf2 activation. Previous... -
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- Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells
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Moon D, Yoon SP, Jang HS, Noh MR, Ha L, Padanilam , Kim J
- KMID: 2467465
- Anat Biol Anthropol.
- 2019 Dec;32(4):121-128.
- doi: 10.11637/aba.2019.32.4.121
Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in primary afferent sensory neurons. Exogenous CGRP can induce cell death in kidney tubular cells. The objective of this study was... -
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- Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property
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Lee JH, Jeong JH, Jeong YG, Kim DK, Lee NS, Na CS, Doh ES, Han SY
- KMID: 2466703
- Anat Cell Biol.
- 2019 Dec;52(4):486-497.
- doi: 10.5115/acb.19.141
The leaf extract of Platycarya strobilacea (PSL) has long been recognized as possessing various health-promoting activities. However, information on its possible protective effects against ischemic stroke is currently lacking. Here,... -
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- Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
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Kim HI, Lee JS, Kwak BK, Hwang WM, Kim MJ, Kim YB, Chung SS, Park KS
- KMID: 2466506
- Diabetes Metab J.
- 2019 Dec;43(6):854-866.
- doi: 10.4093/dmj.2018.0179
BACKGROUND: Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation... -
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- Exercise and Neuroinflammation in Health and Disease
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Seo DY, Heo JW, Ko JR, Kwak HB
- KMID: 2467316
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S82-S92.
- doi: 10.5213/inj.1938214.107
Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces... -
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- Perivascular Stem Cells Suppress Inflammasome Activation during Inflammatory Responses in Macrophages
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Kim J, Kim WJ, Ha KS, Han ET, Park WS, Yang SR, Hong SH
- KMID: 2465882
- Int J Stem Cells.
- 2019 Nov;12(3):419-429.
- doi: 10.15283/ijsc19115
BACKGROUND AND OBJECTIVES: Perivascular stem cells (PVCs) have been identified as precursors of mesenchymal stem cells (MSCs) that offer promising prospects for application in the development of cellular therapies. Although... -
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- Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
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Zhen AX, Piao MJ, Kang KA, Madushan Fernando PDS, Kang HK, Koh YS, Yi JM, Hyun JW
- KMID: 2462883
- Biomol Ther.
- 2019 Nov;27(6):562-569.
- doi: 10.4062/biomolther.2019.061
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that... -
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- Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization
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Pocasap P, Weerapreeyakul N, Thumanu K
- KMID: 2462881
- Biomol Ther.
- 2019 Nov;27(6):540-552.
- doi: 10.4062/biomolther.2019.027
To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane in hepatocellular carcinoma cell... -
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- ICSI using fresh and frozen PESA-TESA spermatozoa to examine assisted reproductive outcome retrospectively
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Javed A, Ramaiah MK, Talkad MS
- KMID: 2462121
- Obstet Gynecol Sci.
- 2019 Nov;62(6):429-437.
- doi: 10.5468/ogs.2019.62.6.429
OBJECTIVE: The male reproductive system generates, accumulates, and transports the sperm. In this study, 2 methods of surgically retrieving sperm, namely, testicular sperm aspiration (TESA) and percutaneous epididymal sperm aspiration... -
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- Alteration of mitochondrial DNA content modulates antioxidant enzyme expressions and oxidative stress in myoblasts
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Min KH, Lee W
- KMID: 2461045
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):519-528.
- doi: 10.4196/kjpp.2019.23.6.519
Mitochondrial dysfunction is closely associated with reactive oxygen species (ROS) generation and oxidative stress in cells. On the other hand, modulation of the cellular antioxidant defense system by changes in... -
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