- The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts
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Son E, Lee D, Woo CW, Kim YH
- KMID: 2471039
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):173-183.
- doi: 10.4196/kjpp.2020.24.2.173
An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of... -
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- MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
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Liu H, Li S, Jiang W, Li Y
- KMID: 2470910
- Korean Circ J.
- 2020 Mar;50(3):250-263.
- doi: 10.4070/kcj.2019.0107
BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion... -
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- Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
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Wang J, Bai T, Wang N, Li H, Guo X
- KMID: 2466565
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):11-18.
- doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid... -
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- Targeted temperature management for ischemic stroke
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Hong JM
- KMID: 2470467
- J Neurocrit Care.
- 2019 Dec;12(2):67-73.
- doi: 10.18700/jnc.190100
Therapeutic hypothermia (TH) or targeted temperature management is an intentional cooling or temperature control technique using a thermostatic equipment (i.e., surface, endovascular, and focal devices) for specific therapeutic purposes. Given... -
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- Mechanisms and therapeutic targets of ischemic acute kidney injury
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Han SJ, Lee HT
- KMID: 2469373
- Kidney Res Clin Pract.
- 2019 Dec;38(4):427-440.
- doi: 10.23876/j.krcp.19.062
Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy and is a significant and frequent cause of morbidity and mortality during... -
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- Neuroimmune interactions and kidney disease
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Hasegawa S, Inoue T, Inagi R
- KMID: 2457720
- Kidney Res Clin Pract.
- 2019 Sep;38(3):282-294.
- doi: 10.23876/j.krcp.19.014
The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a well-studied... -
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- RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia
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Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH
- KMID: 2470111
- Lab Anim Res.
- 2019 Aug;35(2):78-85.
- doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the... -
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- Anesthetic considerations for lung transplantation
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Yoo YC
- KMID: 2454806
- Anesth Pain Med.
- 2019 Jul;14(3):241-248.
- doi: 10.17085/apm.2019.14.3.241
Since the first lung transplantation, developments in surgical techniques, immunosuppressants, preservation solutions, monitoring devices, anesthetic agents, and drugs and devices for hemodynamic support have resulted in improved survival rates after... -
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- Rationale and Design of the High Platelet Inhibition with Ticagrelor to Improve Left Ventricular Remodeling in Patients with ST-Segment Elevation Myocardial Infarction (HEALING-AMI) Trial
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Park Y, Choi SW, Oh JH, Shin ES, Lee SY, Kim J, Kim W, Suh JW, Yang DH, Hong YJ, Chan MY, Koh JS, Hwang JY, Park JH, Jeong YH, HEALING-AMI Trial Investigators
- KMID: 2450389
- Korean Circ J.
- 2019 Jul;49(7):586-599.
- doi: 10.4070/kcj.2018.0415
BACKGROUND AND OBJECTIVES: Impaired recovery from left ventricular (LV) dysfunction is a major prognostic factor after myocardial infarction (MI). Because P2Y12 receptor blockade inhibits myocardial injury, ticagrelor with off-target properties... -
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- tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?
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Kim JS
- KMID: 2449893
- J Stroke.
- 2019 May;21(2):160-174.
- doi: 10.5853/jos.2019.00584
Tissue plasminogen activator (tPA) is the only therapeutic agent approved to treat patients with acute ischemic stroke. The clinical benefits of tPA manifest when the agent is administered within 4.5... -
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- Cortical Bone Derived Stem Cells for Cardiac Wound Healing
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Mohsin S, Houser SR
- KMID: 2441134
- Korean Circ J.
- 2019 Apr;49(4):314-325.
- doi: 10.4070/kcj.2018.0437
Ischemic heart disease can lead to myocardial infarction (MI), a major cause of morbidity and mortality worldwide. Adoptive transfer of multiple stem cell types into failing human hearts has demonstrated... -
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- The role of senescence of bone marrow cells in acute kidney injury
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Lee J, Ko YS, Lee HY, Yang J, Oh S, Jo SK, Cho W, Kim MG
- KMID: 2447141
- Kidney Res Clin Pract.
- 2019 Mar;38(1):25-32.
- doi: 10.23876/j.krcp.18.0114
BACKGROUND: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes.... -
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- Renal sympathetic nerve activation via α₂-adrenergic receptors in chronic kidney disease progression
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Jang HS, Kim J, Padanilam
- KMID: 2447139
- Kidney Res Clin Pract.
- 2019 Mar;38(1):6-14.
- doi: 10.23876/j.krcp.18.0143
Chronic kidney disease (CKD) is increasing worldwide without an effective therapeutic strategy. Sympathetic nerve activation is implicated in CKD progression, as well as cardiovascular dysfunction. Renal denervation is beneficial for... -
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- The safety of one-per-mil tumescent infiltration into tissue that has survived ischemia
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Prasetyono TOH, Nindita E
- KMID: 2446810
- Arch Plast Surg.
- 2019 Mar;46(2):108-113.
- doi: 10.5999/aps.2018.00248
BACKGROUND: The aim of this study was to assess the safety of one-per-mil tumescent injections into viable skin flaps that had survived an ischemic insult, in order to assess the... -
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- Effects of hyperbaric oxygen and iloprost on intestinal ischemia-reperfusion induced acute lung injury
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Yilmaz Y, Tumkaya L
- KMID: 2429752
- Ann Surg Treat Res.
- 2019 Jan;96(1):34-40.
- doi: 10.4174/astr.2019.96.1.34
PURPOSE: To research the effects of iloprost (IL) and hyperbaric oxygen (HBO) combination treatment on lung injury and on tumor necrosis factor alpha (TNF-α), myeloperoxidase (MPO), malondialdehyde (MDA), and soluble... -
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- Critical Care after Lung Transplantation
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Kim SY, Jeong SJ, Lee JG, Park MS, Paik HC, Na S, Kim J
- KMID: 2441237
- Acute Crit Care.
- 2018 Nov;33(4):206-215.
- doi: 10.4266/acc.2018.00360
Since the first successful lung transplantation in 1983, there have been many advances in the field. Nevertheless, the latest data from the International Society for Heart and Lung Transplantation revealed... -
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- Fimasartan attenuates renal ischemia-reperfusion injury by modulating inflammation-related apoptosis
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Cho JH, Choi SY, Ryu HM, Oh EJ, Yook JM, Ahn JS, Jung HY, Choi JY, Park SH, Kim CD, Kim YL
- KMID: 2430088
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):661-670.
- doi: 10.4196/kjpp.2018.22.6.661
Fimasartan, a new angiotensin II receptor antagonist, reduces myocyte damage and stabilizes atherosclerotic plaque through its anti-inflammatory effect in animal studies. We investigated the protective effects of pretreatment with fimasartan... -
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- Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy
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Jang MJ, You D, Park JY, Kim K, Aum J, Lee C, Song G, Shin HC, Suh N, Kim YM, Kim CS
- KMID: 2429548
- Int J Stem Cells.
- 2018 Nov;11(2):157-167.
- doi: 10.15283/ijsc18073
Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for... -
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- Repeated gastric dilatations leading to fatal abdominal compartment syndrome in a patient with bulimia nervosa
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Han SB, Durey A, Lee SJ, Seo YH, Kim JH
- KMID: 2435479
- J Korean Soc Emerg Med.
- 2018 Oct;29(5):551-556.
- doi: 10.0000/jksem.2018.29.5.551
Cases of repeated acute gastric dilatations after binge eating in one patient are rarely reported. We report here a case of repeated acute gastric dilatations in a 22-year-old woman with... -
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- Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats
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Choi EK, Park SH, Lim JA, Hong SW, Kwak KH, Park SS, Lim DG, Jung H
- KMID: 2419730
- Yonsei Med J.
- 2018 Oct;59(8):960-967.
- doi: 10.3349/ymj.2018.59.8.960
PURPOSE: Hydrogen sulfide (H2S) is an endogenous gaseous molecule with important physiological roles. It is synthesized from cysteine by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS). The present study examined... -
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