Korean Lepr Bull.  2003 Dec;36(2):23-29.

The association study on infection of Mycobacterium leprae and RIPK2

Affiliations
  • 1Institute of Hansen's disease, Department of Pathology, College of Medicine, The Catholic University of Korea, Korea.

Abstract

Receptor-interacting serine/threonine kinase 2(RIPK2) is an adaptor molecule involved in the signal pathway of TLRs. However, there is no report on association between RIPK2 expression and infectious disease including mycobacterial disease in which TLRs play main role on interaction of infection. We evaluated relationship between Mycobacterium leprae and RIPK 2 by real-time RT-PCR. This study revealed that RIPK2 expression was down-regulated in the footpads and skin but was up-regulated in the liver, lymph node, and spleen of Mycobacterium leprae-infected nu/nu mice compared with those of non-infected nu/nu mice. It was observed that the IL-12p40, IFN-gamma, and IL-18 involved in the susceptibility of Mycobacterium leprae were down-regulated in the skin and footpad but up-regulated in the liver. These results suggest that regulation of RIPK2 expression is tissue-specific and is associated with M. leprae infection.

Keyword

IFN-gamma; IL-12; Mycobacterium leprae; RIPK2

MeSH Terms

Animals
Communicable Diseases
Interleukin-12
Interleukin-12 Subunit p40
Interleukin-18
Liver
Lymph Nodes
Mice
Mycobacterium leprae*
Mycobacterium*
Phosphotransferases
Signal Transduction
Skin
Spleen
Interleukin-12
Interleukin-12 Subunit p40
Interleukin-18
Phosphotransferases
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