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Protective Effect of Boiled and Freeze-dried Mature Silkworm Larval Powder Against Diethylnitrosamine-induced Hepatotoxicity in Mice

Cho JM, Kim KY, Ji SD, Kim EH

BACKGROUND: Hepatocellular carcinoma (HCC) is a representative inflammation-associated cancer and known to be the most frequent tumors. HCC may also induce important pro- and anti-tumor immune reactions. However, the underlying...
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Anti-proliferative Activity of T-bet

Oh YJ, Shin JH, Won HY, Hwang ES

T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4+ precursor cells. Since T-bet directly binds to the promoter of the IFN-gamma gene and activates its...
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Benzylideneacetophenone derivatives attenuate IFN-gamma-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition

Lee SH, Lim SY, Choi JH, Jung JC, Oh S, Kook KH, Choi YH

The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized...
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Extent of Mycobacterium bovis infection in dairy cattle herds subject to partial culling as determined by an interferon-gamma assay

Je S, Yeo UC, Song T, Kim KC, Park SY, Kim MJ, Cho SN

The interferon-gamma (IFN-gamma) assay is employed as a complementary diagnostic test for bovine tuberculosis (BTB) in many countries. To simplify this assay, we established a 96-well plate format using the...
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Kinetics of IFN-gamma and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease

Ju JM, Lee H, Oh K, Lee DS, Choi EY

Graft-versus-host disease (GVHD) is a fatal complication that occurs after allogeneic hematopoietic stem cell transplantation. To understand the dynamics of CD4 and CD8 T cell production of IFN-gamma and IL-17...
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Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-alpha and Interferon-gamma in Sedentary Men

Jahromi AS, Zar A, Ahmadi F, Krustrup P, Ebrahim K, Hovanloo F, Amani D

Physical activity could be considered one of the factors that affect the immune system status and function. To find the relation between exercise and cytokines, we examined the possible effects...
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A Case of Atypical Cutaneous Tuberculid in an Immunocompromised Patient

Lee JY, Shin SJ, Yoo CS, Kim CW, Kim SS

  • KMID: 2246591
  • Korean J Dermatol.
  • 2013 Sep;51(9):705-708.
Cutaneous tuberculids are relatively rare hypersensitivity reactions to Mycobacterium tuberculosis, characterized by erythematous eruption on the skin of a tuberculosis patient. Papulonecrotic tuberculid, lichen scrofulosorum, erythema induratum and nodular tuberculid...
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Mesenchymal Stem Cell Lines Isolated by Different Isolation Methods Show Variations in the Regulation of Graft-versus-host Disease

Yoo HS, Yi T, Cho YK, Kim WC, Song SU, Jeon MS

Since the discovery of the immunomodulation property of mesenchymal stem cells (MSCs) about a decade ago, it has been extensively investigated whether MSCs can be used for the treatment of...
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Role of Citrullinated Fibrinogen Peptides in the Activation of CD4 T Cells from Patients with Rheumatoid Arthritis

Shin K, Hong S, Choi EH, Lim MK, Shim SC, Ju JH, Lee SH

This study was conducted to determine whether CD4 T cell responses to citrullinated fibrinogen occur in patients with rheumatoid arthritis (RA), especially in HLA-DR4-positive subjects. Whole peripheral blood mononuclear cells...
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Kinetics of IFN-Gamma and TNF-Alpha Gene Expression and Their Relationship with Disease Progression after Infection with Mycobacterium Tuberculosis in Guinea Pigs

Roh IS, Cho S, Eum SY, Cho SN

PURPOSE: Guinea pig is one of the most suitable animal models for Mycobacterium tuberculosis (M. tb) infection since it shows similarities to pulmonary infection in humans. Although guinea pig shows...
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Increased Cytokine and Nitric Oxide Levels in Serum of Dogs Experimentally Infected with Rangelia vitalii

Paim FC, Da Silva A, Paim CB, Franca RT, Costa MM, Duarte MM, Sangoi MB, Moresco RN, Monteiro S, Lopes ST

This study aimed to measure the levels of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin 1 (IL-1), interleukin 6 (IL-6), and nitrite/nitrate (NOx) in serum of dogs experimentally infected with...
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Characteristics between IgE mediated and non-IgE mediated atopic dermatitis in children

Kim HS, Jung JI, Suh SB, Jung JA

PURPOSE: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with a association of genetic, environmental, and immunologic factors in the development of AD. And AD can be classified into...
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In Vitro Induction of Allergen-Specific Interleukin-10-Producing Regulatory B Cell Responses by Interferon-gamma in Non-Immunoglobulin E-Mediated Milk Allergy

Lee SJ, Noh G, Lee JH

PURPOSE: Specific oral immunotherapy (SOIT) using interferon-gamma (IFN-gamma) has been successful as a food allergy treatment. Interleukin-10 (IL-10)-producing regulatory B cells (Br1s) play a role in immune tolerance to food...
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The Expression of Cytokine and Chemokine Related with Dendritic Cell and Effector T Cell in Psoriatic Lesions

Lee KY, Jeon SY, Ko DY, Song KH, Kim KH

  • KMID: 2301611
  • Korean J Dermatol.
  • 2012 Jul;50(7):599-608.
BACKGROUND: T cells and dendritic cells (DCs) are more observed in the psoriatic lesion. Inflammatory DCs stimulate T cell differentiation (Th1 or Th17 cells) by producing IL-12 and IL-23 in...
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Comparison of tuberculin skin test with Interferon-gamma assay for the diagnosis of bovine tuberculosis in Korean cattle

Shin SW, Shin MK, Cha SB, Woo JT, Lee SM, Ku BK, Cho YS, Jung SC, Yoo HS

  • KMID: 1446203
  • Korean J Vet Res.
  • 2011 Jun;51(2):117-121.
Bovine tuberculosis (bTB), caused primarily by Mycobacterium bovis, continues to exert an economic loss, even in countries with active control measures, and is one of zoonotic diseases enable to be...
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Comparison of Immune Response between Pediatric Bronchial Asthma and Sinusitis

Kim HS, Lee JH, Yun HJ, Kim BG, Jung JA

  • KMID: 2315022
  • Pediatr Allergy Respir Dis.
  • 2010 Sep;20(3):159-165.
PURPOSE: Bronchial asthma and sinusitis have been grouped together and classified as one airway-related disease, with the same underlying inflammatory etiology. Through serological examination, we ascertained a difference in the...
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Association of preterm birth with IFN-gamma, IL-10, and CYP 1A1 gene in Korean women

You SY, Kim JM, Lee KA, Park MH, Kim YJ, Chun SH

OBJECTIVE: To investigate the association between preterm birth and cytokine genes (IFN-gamma, interleukin (IL)-10) in intrauterine infection and enzyme gene (CYP1A1) in oxidative stress response. METHODS: This study involved a case-control...
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Suppression of CD4+ T-Cells in the Spleen of Mice Infected with Toxoplasma gondii KI-1 Tachyzoites

Kim WH, Shin EH, Kim JL, Yu SY, Jung BK, Chai JY

Toxoplasma gondii KI-1, a recent new isolate from Korea, shows similar pathogenicity and infectivity to mice compared to the virulent RH strain. To understand characteristics of host immunity, including immune...
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Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis

Chung BS, Lee JK, Choi MH, Park MH, Choi D, Hong ST

This study examined the association of cytokine gene polymorphisms with intrahepatic bile duct wall fibrosis in human clonorchiasis. A total of 240 residents in Heilongjiang, China underwent ultrasonography, blood sampling,...
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Lambs Infected with UV-Attenuated Sporocysts of Sarcocystis ovicanis Produced Abnormal Sarcocysts and Induced Protective Immunity against a Challenge Infection

Abdel-Baki AA, Allam G, Sakran T, El-Malah E

The present study surveyed the prevalence of natural infection of the sheep esphagus muscle with sarcocysts of Sarcocystis ovicanis and examined induction of protective immunity using UV-attenuated sporocysts. The overall...
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