- Optimization for cell lysate preparation of M. leprae from infected nude mouse
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Kang TJ, Lee SB, Chae GT
- KMID: 2139271
- Korean Lepr Bull.
- 2001 Jun;34(1):47-56.
The method of cell lysate preparation of M. leprae is an important technique in the study of leprosy. This report describes the optimization of method for cell lysate preparation of... -
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- The role of mycobacterial katG gene in activation of isoniazid
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Kang TJ, Chae GT
- KMID: 1584950
- Korean Lepr Bull.
- 2000 Dec;33(2):55-66.
Since Mycobacterium leprae, the causative organism of Leprosy, proliferate inside macrophages, it has been speculated that catalase encoded by the katG gene may protect acid-fast bacilli from the deleterious effects... -
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- Effects of Dexamethasone on expressions of IFN-gamma and IL-4 by PBMCs in response to IL-12
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Heo SH, Lee SB, Chae GT
- KMID: 2053859
- Korean Lepr Bull.
- 2002 Dec;35(2):3-12.
Dexamethasone is a widely used anti-inflammatory agent for a broad spectrum of diseases. The effectiveness of this agent is thought to be due to the capacity to modulate cytokine production... -
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- The application of TD (Touch-Down) PCR in Diagnosis of leprosy and Detection of MDT-resistant M. leprae
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Kim SK, Lee SB, Kang TJ, Chae GT
- KMID: 1609921
- Korean Lepr Bull.
- 2001 Dec;34(2):13-21.
There are several methods for diagnosis of leprosy, including AFB stain, the measurement of PGL-1 (phenolic glycolipid - 1) antigen titer, and DNA-PCR. In this study, we have used the... -
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- Expression of Nucleotide-oligomerization Domain (NOD) and Related Genes in Mouse Tissues Infected with Mycobacterium leprae
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Kim TH, Chae GT, Kang TJ
- KMID: 2132706
- Immune Netw.
- 2015 Dec;15(6):319-324.
- doi: 10.4110/in.2015.15.6.319
The nucleotide-oligomerization domain (NOD) is an important molecule involved in host defense against bacterial infection. To study the role of NODs in the host response to Mycobacterium leprae, we measured... -
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- The association study on infection of Mycobacterium leprae and RIPK2
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Kim BC, Kang TJ, Chae GT
- KMID: 1921046
- Korean Lepr Bull.
- 2003 Dec;36(2):23-29.
Receptor-interacting serine/threonine kinase 2(RIPK2) is an adaptor molecule involved in the signal pathway of TLRs. However, there is no report on association between RIPK2 expression and infectious disease including... -
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- The effect of TLR2 mutation in IL-12 production according to type of leprosy
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Kang TJ, Lee SB, Chae GT
- KMID: 1609918
- Korean Lepr Bull.
- 2001 Dec;34(2):3-12.
Recently, many reports suggest that the activation of Toll-like receptor 2 (TLR2) by microbial lipoproteins may initiate innate defense mechanism against infectious pathogens. Especially, TLR2 is critical in the immune... -
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- The Development Tasks of Medical School Accreditation in Korea
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Lee MS, Suh DJ, Yang EB, Chai JY, Chae GT, Ahn DS, Kim DG
- KMID: 2306871
- Korean J Med Educ.
- 2002 May;14(1):73-83.
The Accreditation Board for Medical Education in Korea, ABMEK, is nongovernmental appraisal organization that was established at July 2, 1998. The organization is contributing to the improvement of medical education... -
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- Identification of regulatory sequence within the promoter of M.leprae-specific 18-kDa gene and its binding factor(s)
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Kim MJ, Kim YK, Chae GT
- KMID: 2139281
- Korean Lepr Bull.
- 2000 Jun;33(1):107-113.
A central question to the pathogenesis of leprosy is how Mycobacterium leprae, the causative agent of leprosy, survives and replicates within macrophages. 18-kDa protein of M. leprae, a major antigen,... -
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- Comparison of rpoT gene of M. leprae strain from korean and foreign leprosy patients
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Kang TJ, Kim SK, Kim NH, Matsuoka M, Chae GT
- KMID: 1993560
- Korean Lepr Bull.
- 2004 Jul;37(1):3-14.
The variance of tandem repeats in the rpoT gene of Mycobacterium leprae was recently demonstrated. The objects of this study was to examine the proportion and distributions of the genotypes... -
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- Changes of Leprosy Research in the Post Genomic Era
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Chae GT
- KMID: 2139268
- Korean Lepr Bull.
- 2001 Jun;34(1):3-12.
Leprosy has turned out to be a minor health problem in Korea due to implementation of multidrug therapy, intensive case detection and mobile works for the villages for last 20... -
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- Modern History of Hansen's Disease in Korea
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Chae GT
- KMID: 2509899
- Infect Chemother.
- 2020 Dec;52(4):647-653.
- doi: 10.3947/ic.2020.52.4.647
Modern history of Hansen's Disease (HD) in Korea begins with nationwide use of the chemotherapeutic agent Diamino Diphenyl Sulphone for the patients in 1955. Definition of the case was different... -
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- HLA-A, B and DRB1 Genes Related with Susceptibility and Type of Hansen's Disease
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Chae GT, Lee SB, Kang TJ, Kim JP, Ko YH
- KMID: 1584951
- Korean Lepr Bull.
- 2000 Dec;33(2):67-78.
To find out whether the susceptibility to Hansen's disease are associated with HLA genes, serological and nucleotide typing of HLA-A, B, and DRB1 alleles have been conducted in 301 Hansen's... -
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- Mutations in folP1, rpoB, and gyrB associated with multiple drug resistance in Mycobacterium leprae isolates from South Korea
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Lee SB, You EY, Kang TJ, Kim SK, Kim JP, Ko YH, Chae GT
- KMID: 1516978
- Korean Lepr Bull.
- 2003 Jul;36(1):3-9.
The emergence of multiple drug resistant Mycobacterium leprae has emphasized the need for early decision of effective antileprosy drug in the treatment for leprosy patients. Mutations in the genes associated... -
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- The Role of Intracellular Receptor NODs for Cytokine Production by Macrophages Infected with Mycobacterium leprae
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Kang TJ, Chae GT
- KMID: 2150731
- Immune Netw.
- 2011 Dec;11(6):424-427.
- doi: 10.4110/in.2011.11.6.424
The nucleotide-oligomerization domain (NOD) proteins are members of the NOD-like receptor (NLR) family, which are intracellular and cytoplasmic receptors. We analyzed the role of NODs for cytokine production by macrophages... -
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- Interferon-gamma (IFN-gamma) increases CD1 expression through inhibition of IL-10 secretion from M.leprae-infected macrophages of lepromatous leprosy
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Lee SB, Kim SK, Lee HJ, Shin HK, Kim JP, Ko YH, Kim SH, Chae GT
- KMID: 1584949
- Korean Lepr Bull.
- 2000 Dec;33(2):47-54.
The CD1 system is a novel antigen-presenting system for T cell recognition of lipid and glycolipids in antimicrobial immunity. Lepromatous leprosy is characterized by lack of cell-mediated immunity against M.leprae.... -
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- Microhistorical Approach of the Self-respect of Hansen’s Disease patient through Testament of Mr. Kim Jeong-hee in National Sorokdo Hospital
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Chae GT
- KMID: 2537511
- Korean Lepr Bull.
- 2022 Dec;55(1):.
This work explores how Mr. Kim Jeong-hee who is a person affected by leprosy[(Hansen’s Disease)] established self-respect and self-esteem, self-actualization, and self-love during 1935 to present 2021 with text of... -
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- Perceptions of Teachers to the Specific Behavioral Objectives in Basic Medical Sciences and its Implementation in Teaching Situation
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Baik SH, Park CW, Cho MH, Chae GT
- KMID: 2307050
- Korean J Med Educ.
- 1991 Dec;3(2):26-34.
The purpose of this study was to investigate the perceptions of teachers to the learning objectives (specific behavioral objectives, SBO) of their own specialty subjects at real educational situation and... -
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- The Change of Bacillary Index during WHO Standard Multi-drug Therapy in Multi-bacillary Leprosy: Among the patients in The National Sorokdo Hospital
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Lee JH, Kim DH, Choi SW, Kim HO, Chae GT, Kim TY
- KMID: 1595047
- Korean J Dermatol.
- 2001 Mar;39(3):318-322.
BACKGROUND: There were no effective methods to monitor the treatment of leprosy. Anti-PGL-1 ELISA test and polymerase chain reaction(PCR) were used for monitoring the treatment, however many restrictions have been... -
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- Differentiation of Osteoblast Progenitor Cells from Human Umbilical Cord Blood
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Hong SJ, Lee EA, Chae GT, Han H
- KMID: 1571519
- Immune Netw.
- 2002 Sep;2(3):166-174.
- doi: 10.4110/in.2002.2.3.166
BACKGROUND: Human umbilical cord bloods, which could be taken during the delivery are utilized as a source of hematopoietic stem cells. Also in cord blood, there are several kinds of... -
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