- Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp
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Ryu G, Bae JS, Kim JH, Kim EH, Lyu L, Chung YJ, Mo JH
- KMID: 2471233
- Allergy Asthma Immunol Res.
- 2020 May;12(3):507-522.
- doi: 10.4168/aair.2020.12.3.507
PURPOSE: Th17-associated inflammation is increased in chronic rhinosinusitis with nasal polyp (CRSwNP), and is associated with disease severity and steroid resistance. Overexpressed interleukin (IL)-17A affects CRSwNP by tissue remodeling, eosinophilic... -
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- Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells
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Cheon YH, Kim MS, Kim JY, Kim DH, Han SY, Lee JH
- KMID: 2471037
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):157-163.
- doi: 10.4196/kjpp.2020.24.2.157
Chronic inflammatory airway diseases, such as chronic rhinosinusitis, chronic obstructive pulmonary disease, and asthma, are associated with excessive mucus production. Hence, the regulation of mucus production is important for the... -
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- Ezrin-radixin-moesin proteins are regulated by Akt-GSK3β signaling in the rat nucleus accumbens core
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Kim WY, Cai WT, Jang JK, Kim JH
- KMID: 2466576
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):121-126.
- doi: 10.4196/kjpp.2020.24.1.121
The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases... -
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- A PAS-Containing Histidine Kinase is Required for Conidiation, Appressorium Formation, and Disease Development in the Rice Blast Fungus, Magnaporthe oryzae
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Shin JH, Gumilang A, Kim MJ, Han JH, Kim KS
- KMID: 2470180
- Mycobiology.
- 2019 Dec;47(4):473-482.
- doi: 10.1080/12298093.2019.1689037
Rice blast disease, caused by the ascomycete fungus Magnaporthe oryzae, is one of the most important diseases in rice production. PAS (period circadian protein, aryl hydrocarbon receptor nuclear translocator protein,... -
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- Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats
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Kang JB, Park DJ, Koh PO
- KMID: 2470014
- Lab Anim Res.
- 2019 Dec;35(4):172-179.
- doi: 10.1186/s42826-019-0026-9
Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral... -
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- Baicalein Treatment Promotes Osteoblast Proliferation and Osteogenic Differentiation through Activation of Immediate Early Response 3
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Lee SI
- KMID: 2469741
- J Dent Hyg Sci.
- 2019 Dec;19(4):254-260.
- doi: 10.17135/jdhs.2019.19.4.254
BACKGROUND: The primary aims of periodontal disease treatment is to remove dental plaque and calculus, the main causes of tooth loss, and restore periodontal tissue destroyed by inflammation. Periodontal disease... -
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- Skeletal mineralization: mechanisms and diseases
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Michigami
- KMID: 2468721
- Ann Pediatr Endocrinol Metab.
- 2019 Dec;24(4):213-219.
- doi: 10.6065/apem.2019.24.4.213
Skeletal mineralization is initiated in matrix vesicles (MVs), the small extracellular vesicles derived from osteoblasts and chondrocytes. Calcium and inorganic phosphate (Pi) taken up by MVs form hydroxyapatite crystals, which... -
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- G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells
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Cho E, Kwon YJ, Ye DJ, Baek HS, Kwon TU, Choi HK, Chun YJ
- KMID: 2462887
- Biomol Ther.
- 2019 Nov;27(6):591-602.
- doi: 10.4062/biomolther.2019.063
Human breast cancer cell line, MDA-MB-231, is highly invasive and aggressive, compared to less invasive cell line, MCF-7. To explore the genes that might influence the malignancy of MDA-MB-231, DNA... -
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- FGF-17 from Hypoxic Human Wharton's Jelly-Derived Mesenchymal Stem Cells Is Responsible for Maintenance of Cell Proliferation at Late Passages
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Han KH, Kim MH, Jeong GJ, Kim AK, Chang JW, Kim DI
- KMID: 2465898
- Int J Stem Cells.
- 2019 Jul;12(2):279-290.
- doi: 10.15283/ijsc18042
BACKGROUND AND OBJECTIVES: Although it is well known that hypoxic culture conditions enhance proliferation of human mesenchymal stem cells, the exact mechanism is not fully understood. In this study, we... -
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- Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
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Ko JY, Lee EJ, Park JH
- KMID: 2455087
- Biomol Ther.
- 2019 Jul;27(4):337-341.
- doi: 10.4062/biomolther.2019.056
Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between... -
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- Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice
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Nguyen HT, Cho DH, Jang SH, Han SK, Park SJ
- KMID: 2450494
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):271-279.
- doi: 10.4196/kjpp.2019.23.4.271
The lamina II, also called the substantia gelatinosa (SG), of the trigeminal subnucleus caudalis (Vc), is thought to play an essential role in the control of orofacial nociception. Glycine and... -
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- p62 Negatively Regulates TLR4 Signaling via Functional Regulation of the TRAF6-ECSIT Complex
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Kim MJ, Min Y, Kwon J, Son J, Im JS, Shin J, Lee KY
- KMID: 2450201
- Immune Netw.
- 2019 Jun;19(3):e16.
- doi: 10.4110/in.2019.19.e16
Sequestosome 1 (SQSTM1, p62), a ubiquitin binding protein, plays a role in cell signaling, oxidative stress, and autophagy. However, its functional role in inflammatory signaling is controversial. Recent studies have... -
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- Recent Advances in Biosensors for Nucleic Acid and Exosome Detection
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Fu Z, Lu YC, Lai JJ
- KMID: 2447210
- Chonnam Med J.
- 2019 May;55(2):86-98.
- doi: 10.4068/cmj.2019.55.2.86
Biosensors are analytical devices for biomolecule detection that compromise three essential components: recognition moiety, transducer, and signal processor. The sensor converts biomolecule recognition to detectable signals, which has been applied... -
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- Rab GTPases as Physiological Substrates of LRRK2 Kinase
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Seol W, Nam D, Son I
- KMID: 2450209
- Exp Neurobiol.
- 2019 Apr;28(2):134-145.
- doi: 10.5607/en.2019.28.2.134
LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities... -
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- Anti-inflammatory activities of sinensetin on LPS-stimulated L6 skeletal muscle cells
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Kim JA, Ha SE, Kim SM, Vetrivel P, Kim GS, Kim EH
- KMID: 2448283
- J Biomed Transl Res.
- 2019 Mar;20(1):1-7.
- doi: 10.12729/jbtr.2019.20.1.001
Inflammation is an important protective response mechanism that occurs against microbial invasion or injury. However, excessive inflammation may lead to cause of morbidity and mortality in diseases. The activated macrophages... -
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- Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome
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Ramana CV
- KMID: 2447798
- Genomics Inform.
- 2019 Mar;17(1):e8.
- doi: 10.5808/GI.2019.17.1.e8
Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells... -
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- Prediction of itching diagnostic marker through RNA sequencing of contact hypersensitivity and skin scratching stimulation mice models
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Kim YW, Zhou T, Ko EA, Kim S, Lee D, Seo Y, Kwon N, Choi T, Lim H, Cho S, Bae G, Hwang Y, Kim D, Park H, Lee M, Jang E, Choi J, Bae H, Lim I, Bang H, Ko JH
- KMID: 2438089
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):151-159.
- doi: 10.4196/kjpp.2019.23.2.151
Pruritus (itching) is classically defined as an unpleasant cutaneous sensation that leads to scratching behavior. Although the scientific criteria of classification for pruritic diseases are not clear, it can be... -
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- New Insights into the Molecular and Cellular Mechanism of Antipsychotics
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Kim SH
- KMID: 2439023
- J Korean Neuropsychiatr Assoc.
- 2019 Feb;58(1):12-17.
- doi: 10.4306/jknpa.2019.58.1.12
The serendipitous discovery of drugs with antipsychotic action has provided a clue to understanding the pathogenesis of psychotic disorders and to develop so called ‘antipsychotics’ drugs. From the ‘dopamine hypothesis’... -
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- Gene Expression Profile of Olfactory Transduction Signaling in an Animal Model of Human Multiple Sclerosis
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Kim J, Ahn M, Choi Y, Ekanayake , Park CM, Moon C, Jung K, Tanaka A, Matsuda H, Shin T
- KMID: 2439008
- Exp Neurobiol.
- 2019 Feb;28(1):74-84.
- doi: 10.5607/en.2019.28.1.74
Olfactory dysfunction occurs in multiple sclerosis in humans, as well as in an animal model of experimental autoimmune encephalomyelitis (EAE). The aim of this study was to analyze differentially expressed... -
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- Auditory Deficits in Patients With Mild and Moderate Obstructive Sleep Apnea Syndrome: A Speech Syllable Evoked Auditory Brainstem Response Study
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Fu Q, Wang T, Liang Y, Lin Y, Zhao X, Wan J, Fan S
- KMID: 2437492
- Clin Exp Otorhinolaryngol.
- 2019 Feb;12(1):58-65.
- doi: 10.21053/ceo.2018.00017
OBJECTIVES: The energy consumption process of cochlea and neural signal transduction along the auditory pathway are highly dependent on blood oxygen supply. At present, it is under debate on whether... -
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