Korean J Thorac Cardiovasc Surg.
2000 Jan;33(1):1-6.
The Contents of Tumor Necrosis Factor-alpha and Interleukin-6 in Right Auricular
Tissue
- Affiliations
-
- 1Department of Thoracic and Cardiovascular Surgery, College of Medicine, Kosin Unversity, Pusan.
Abstract
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BACKGROUND: TNF-alpha plays a major role in producing left ventricular dysfunction
cardio-myopathy pulmonary edema and inhibits the compensatory mechanism of congestive heart
failure. IL-6 is an acute reactant of immune reaction and also known to control immune
reaction but its function in the myocyte was not clearly investigated. Author's performed
this experiment to investigate the contents of TNF-alpha and IL-6 on the assumption that TNF-alpha and IL-6 may reside in nonfailing heart that has gone cardiac surgery and play some role in cardiac function.
MATERIAL AND METHOD: Right auricular tissues were sampled from 12 patients
who had undergone total corrective surgery for both congenital and acquired heart diseases
from January 1998 to June 1998 in Kosin Universcfy Gospel hospital. The quantitive
analysis of TNF-alpha and IL-6 were assessed by ELISA method in right auricular tissue.
Hemodynamic values about the pressure of ventricle atrium aorta pulmonary artery and cardiac
index pulmonary and systemic vascular resistance and cardiac output were measured by
echocardiography and cardiac catheterization and biochemical analyses of LDH & AST
were done before operation. statistical analysis was by Paired Student t-test. Patients
were divided into children(under 15 years olds) and adults groups and the data was compared
beween two groups.
CONCLUSIONS
Mild pulmonary hypertension and increased pulmonary vascular
resistance were existed in both group. The contents of tissue TNF-alpha IL-6 in each group were independent of each data.