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Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease

Oh CM, Ryu D, Cho S, Jang Y

Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP...
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Clinical Impact of Implantable Cardioverter-Defibrillator Therapy and Mortality Prediction Model for Effective Primary Prevention in Korean Patients

Bae MH, Cho Y, Hwang J, Park HS, Han S, Lee YS, Cho HJ, Jung BC, Lee CH, Hyun DW, Park JS, Ahn J, Kim KH, Shin DG

BACKGROUND: Studies on the efficacy of implantable cardioverter-defibrillator (ICD) therapy for primary prevention in Asian patients are relatively lacking compared to those for secondary prevention. Also, it is important to...
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Cardiac Magnetic Resonance Feature Tracking in Aortic Stenosis: Exploration of Strain Parameters and Prognostic Value in Asymptomatic Patients with Preserved Ejection Fraction

Kim MY, Park EA, Lee W, Lee SP

OBJECTIVE: To determine the most valuable cardiac magnetic resonance feature tracking (CMR-FT) parameters for evaluating aortic stenosis (AS) and determine whether they can predict the prognosis in asymptomatic AS patients...
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Mitochondrial Mechanisms in Diabetic Cardiomyopathy

Gollmer J, Zirlik A, Bugger H

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus...
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Echocardiographic Evaluation of Axial Spondyloarthritis in Korea: Data From the Catholic Axial Spondyloarthritis Cohort

Min HK, Lee J, Ju JH, Kwok SK, Youn HJ, Park SH

OBJECTIVE: Axial spondyloarthritis (axSpA) is often accompanied by cardiac manifestations, such as valvular heart disease. In this prospective cohort study, we evaluated the incidence of cardiac abnormalities in Korean axSpA...
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Surviving Takayasu's Arteritis—A Young Girl with Long Segment Stenosis of the Descending Thoracic Aorta and Myocarditis

Abas SI, Ramli KA, Tiong KG, Mohammed Y

We report the case of a 12-year-old girl who presented with heart failure symptoms that were treated as dilated cardiomyopathy. The echocardiogram showed a dilated left ventricle, poor ejection fraction,...
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An Empirical Study on the Effect of Short-Term Regular Vitamin D3 Supplement Therapy on Blood Pressure and Exercise Tolerance in Heart Failure Patients

Hosseinzadeh F, Oskouei NJ, Ghavamzadeh S

The receptor of vitamin D is expressed in almost all body cells, including vascular endothelial cells and cardiomyocytes. Vitamin D deficiency has been observed widespread amongst heart failure (HF) patients,...
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Effect of Low-Dose Nebivolol in Patients with Acute Myocardial Infarction: A Multi-Center Observational Study

Sim DS, Hyun DY, Jeong MH, Kim HS, Chang K, Choi DJ, Han KR, Ahn TH, Bae JH, Choi SW, Park JS, Hur SH, Chae JK, Oh SK, Cha KS, Hwang JY

The optimal dose of beta blockers after acute myocardial infarction (MI) remains uncertain. We evaluated the effectiveness of low-dose nebivolol, a beta1 blocker and a vasodilator, in patients with acute...
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Cardiorenal syndrome

Kim MG

To maintain homeostasis of the cardiovascular system, the heart and kidney act bidirectionally. Therefore, acute or chronic dysfunction of one organ can cause dysfunction in the other. This phenomenon is...
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Infantile Hepatic Hemangioma: Avoiding Unnecessary Invasive Procedures

Ernst L, Grabhorn E, Brinkert F, Reinshagen K, Königs I, Trah J

Infantile hepatic hemangioma, the most common vascular tumor of the liver in infancy, can occur with acute postnatal liver and congestive heart failure. Nevertheless, its course is often benign, and...
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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts

You SC, Jung S, Swerdel JN, Ryan PB, Schuemie M, Suchard MA, Lee S, Cho J, Hripcsak G, Park RW, Park S

BACKGROUND AND OBJECTIVES: 2018 ESC/ESH Hypertension guideline recommends 2-drug combination as initial anti-hypertensive therapy. However, real-world evidence for effectiveness of recommended regimens remains limited. We aimed to compare the effectiveness...
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Non-Vitamin K Antagonist Oral Anticoagulants in Medical Conditions at High Risk of Thromboembolism beyond Atrial Fibrillation

Hong KS

Non-Vitamin K antagonist oral anticoagulants (NOACs) have been extensively investigated in medical conditions at high risk of venous or arterial thrombosis other than atrial fibrillation (AF), including hip or knee...
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Diagnostic accuracy and temporal impact of ultrasound in patients with dyspnea admitted to the emergency department

Gaber HR, Mahmoud MI, Carnell J, Rohra A, Wuhantu J, Williams S, Rafique Z, Peacock WF

OBJECTIVE: Few studies have prospectively evaluated the diagnostic accuracy and temporal impact of ultrasound in the emergency department (ED) in a randomized manner. In this study, we aimed to perform...
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Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond

Siddik MA, Shin AC

Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in our body; thus, they need to be obtained from food. They have shown to provide many physiological...
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Prevalence, Characteristics, and Clinical Significance of Concomitant Cardiomyopathies in Subjects with Bicuspid Aortic Valves

Jeong H, Shim CY, Kim D, Choi JY, Choi KU, Lee SY, Hong GR, Ha JW

PURPOSE: The present study aimed to investigate the prevalence, characteristics, and clinical significance of concomitant specific cardiomyopathies in subjects with bicuspid aortic valves (BAVs). MATERIALS AND METHODS: A total of 1186...
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The mortality benefit of carvedilol versus bisoprolol in patients with heart failure with reduced ejection fraction

Choi KH, Lee GY, Choi JO, Jeon ES, Lee HY, Lee SE, Kim JJ, Chae SC, Baek SH, Kang SM, Choi DJ, Yoo BS, Kim KH, Cho MC, Park HY, Oh BH

BACKGROUND/AIMS: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of...
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Temporal Trends of Cardiac Implantable Electronic Device Implantations: a Nationwide Population-based Study

Lee JH, Lee SR, Choi EK, Jeong J, Park HD, You SJ, Lee SS, Oh S

BACKGROUND AND OBJECTIVES: Implantation of cardiac implantable electronic devices (CIED), including permanent pacemakers (PM), implantable cardioverter-defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices, has increased significantly over the past several...
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Tachycardia induced Cardiomyopathy

Kim DY, Kim SH, Ryu KH

Recent studies on radiofrequency catheter ablation (RFCA) in atrial fibrillation show its effectiveness in heart failure (HF) patients; hence, tachycardia-induced cardiomyopathy (T-CMP) is gaining attention. Tachycardia-mediated cardiomyopathy is a reversible...
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Normal Reference Plots for the Bioelectrical Impedance Vector in Healthy Korean Adults

Oh JH, Song S, Rhee H, Lee SH, Kim DY, Choe JC, Ahn J, Park JS, Shin MJ, Jeon YK, Lee HW, Choi JH, Lee HC, Cha KS

BACKGROUND: Accurate volume measurement is important in the management of patients with congestive heart failure or renal insufficiency. A bioimpedance analyser can estimate total body water in litres and has...
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