Korean J Med.  2004 Mar;66(3):259-266.

Serum adiponectin concentration according to visceral fat amount and its relationship of metabolic risk factors in premenopausal obese women

• Kim SJ
• Park KG
• Kim HK
• Kim MK
• Lee SW
• Hwang JS
• Han SW
• Hur SH
• Lee IK

Abstract

BACKGROUND: Adiponectin is adipose specific protein, which we considered to have metabolic and endocrine function in metabolic syndrome including obesity and insulin resistance. We measured serum adiponectin concentrations and compared them with body fat distribution and metabolic risk factors.
METHODS
112 premenopausal obese women were participated in this study. We measured plasma adiponectin concentration and metabolic risk factors such as fasting glucose and insulin, triglyceride, systolic blood pressure (SBP) and diastolic blood pressure (DBP). Subcutaneous adipose tissue area (SAT) and visceral adipose tissue area (VAT) were determined by computed tomography. Body mass index (BMI), waist to hip ratio (WHR) and homeostasis model assessment (HOMA-IR) were calculated.
RESULTS
Serum adiponectin concentration was inversely correlated with fasting insulin level, HOMA-IR, triglyceride, SBP, DBP, WHR, BMI and VAT, whereas HDL-cholesterol was positively correlated (all p values<0.05). VAT, SBP, and HDL-cholesterol level were independent variables of serum adiponectin concentrations.
CONCLUSION
The present study demonstrates that decreased plasma level of adiponectin is significantly associated with metabolic risk factors including body fat distribution; serum adiponectin level is determined by VAT, whereas SAT has no relation with serum adiponectin level.

Keyword

Adiponectin; Obesity; Metabolic syndrome; Visceral fat; Subcutaneous fat

MeSH Terms

Adiponectin*
Blood Pressure
Body Fat Distribution
Body Mass Index
Fasting
Female
Glucose
Homeostasis
Humans
Insulin
Insulin Resistance
Intra-Abdominal Fat*
Obesity
Plasma
Risk Factors*
Subcutaneous Fat
Triglycerides
Waist-Hip Ratio
Adiponectin
Glucose
Insulin