J Korean Cancer Assoc.  2000 Oct;32(5):962-971.

Obesity Related to Breast Cancer Risk by Hormonal Receptor Status

• Yoo KY
• Park SK
• Kang D

Abstract

PURPOSE: A hospital-based case-control study was designed to assess whether obesity may differ in breast cancer risk according to the estrogen receptor (ER) or progesterone receptor (PR) status.
MATERIALS AND METHODS
Information on life-styles was obtained in a hospital-based cancer registry at the Aichi Cancer Center Hospital, Japan, 1988~1992. Newly diagnosed cases with breast cancer (n=1,154) and controls with no history of cancer (n=21,714) were selected. Body mass index with known and suspected risk factors for breast cancer was included simultaneously in the logistic regression model. Hypothesis tests for differences in odds ratios were done by Wald test based on the polytomous logistic regression models.
RESULTS
Both current weight and body mass index were significantly related to the risk of breast cancer; OR for body weight per 5 kg=1.11 (1.05~1.73), OR for body mass index per 10 kg/m2=1.54 (1.25~1.90). The risks of both body weight and body mass index, however, was not modified by ER, nor by PR.
CONCLUSION
This study strongly suggests that obesity may be associated with breast cancer risk. The possibility that obesity differs according to hormonal receptor status should be pursued in further studies.

Keyword

Breast neoplasm; Body mass index; Obesity; Estrogen receptor; Progesterone receptor

MeSH Terms

Body Mass Index
Body Weight
Breast Neoplasms*
Breast*
Case-Control Studies
Estrogens
Japan
Logistic Models
Obesity*
Odds Ratio
Receptors, Progesterone
Risk Factors
Estrogens
Receptors, Progesterone