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Characteristics and Prognosis of Estrogen Receptor Low-Positive Breast Cancer

Kim MC, Park MH, Choi JE, Kang SH, Bae YK

Purpose: The updated American Society of Clinical Oncology/College of American Pathologists guideline for estrogen receptor (ER) testing recommends that breast cancer with ER expression in 1–10% of tumor cells should...
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Progesterone Receptor Expression as a Prognostic Factor in Luminal B Breast Cancer

Lim S, Lee Y, Kim J, Cho H, Yang K, Park K, Kim J, Sin Y, Seo Y, Gwak G

Purpose: The luminal subtype of breast cancer has heterogeneous biological characteristics with respect to the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and Ki-67....
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Osteoporotic Fractures among Selective Estrogen Receptor Modulator Users in South Korea: Analysis Using National Claims Database

Park JW, Lee YK, Choi Y, Ha YC

Background: We evaluated (1) compliance with selective estrogen receptor modulator (SERM) use in postmenopausal women; and (2) the risk of osteoporotic fractures according to compliance and other patient characteristics. Methods: National...
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Estrogen Receptor β Expression and Its Clinical Implication in Breast Cancers: Favorable or Unfavorable?

Choi Y

There are two estrogen receptor (ER) genes (ESR1/ERα and ESR2/ERβ) in humans. Of those.ERβ, the second ER isotype identified in 1996, is differentially expressed in different phenotypes and molecular subtypes...
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Determination of the Estrogen Receptor Status of Leptomeningeal Metastasis in Patients with Metastatic Breast Cancer Using [ 18 F]-FES PET/CT: a Case Report

Ryu J, Jeong JH, Moon DH, Lee DY

Accurate determination of the hormone receptor status in patients with breast cancer is necessary to provide better palliative treatment because of the frequent discordant status of hormone receptors between primary...
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Knockdown of vps54 aggravates tamoxifen-induced cytotoxicity in fission yeast

Lee S, Nam M, Lee AR, Baek ST, Kim MJ, Kim JS, Kong AH, Lee M, Lee SJ, Kim SY, Kim DU, Hoe KL

Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)‒positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To...
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Expression of Estrogen and Progesterone Receptors in Papillary Thyroid Carcinoma in Korea

Ahn HY, Song RY, Ahn HS, Kim HS

Purpose The aim of this study was to examine the rate of expression of estrogen receptor α (ERα) and β1 (ERβ1), progesterone receptor (PR), and rate of overexpression of epidermal...
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Incidence and Risk of Venous Thromboembolism in Bisphosphonates and Selective Estrogen Receptor Modulators Treatment in Korea

Park SY, Kim SH, Kim TY, Lee YK, Ha YC, Jang S, Ahn SH, Kim HY

Background: Selective estrogen receptor modulators (SERMs) were associated with an increased risk of venous thromboembolism (VTE) due to the estrogen effect. In this study, we investigated the effect of SERMs...
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Optimization of adipogenic differentiation conditions for canine adipose-derived stem cells

Kim JY, Park EJ, Kim SM, Lee HJ

Background: Canine adipose-derived stem cells (cADSCs) exhibit various differentiation properties and are isolated from the canine subcutaneous fat. Although cADSCs are valuable as tools for research on adipogenic differentiation, studies...
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Comparison of Bone Mineral Density and Markers of Bone Turnover in Osteoporotic Women after 6-Month Treatment with Alendronate or Bazedoxifene: A Randomized Controlled Trial

Han HS, Cho SH, Park MS, Sung KH, Lee KM

Background: In a randomized controlled trial, we compared the bone mineral densities (BMDs) and blood markers of bone turnover during short-term treatment of osteoporotic women with bisphosphonate alendronate or bazedoxifene,...
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Understanding the Mechanistic Link between Bisphenol A and Cancer Stem Cells: A Cancer Prevention Perspective

Winz C, Suh N

Endocrine disruptors, such as bisphenol A (BPA), have become more frequently present in the environment as contaminants, especially in industrialized countries. Long-term effects of these environmental contaminants in humans are...
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Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women

Sindiani AM, Batiha O, Al-zoubi E, Khadrawi S, Alsoukhni G, Alkofahi A, Alahmad NA, Shaaban S, Alshdaifat E, Abu-Halima M

Objective: Poor ovarian response (POR) refers to a subnormal follicular response that leads to a decrease in the quality and quantity of the eggs retrieved after ovarian stimulation during assisted...
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The secular trends in the use of medications for osteoporosis in South Korea using Intercontinental Medical Statistics Health Sales Audit 2006-2018

Lee N, Choi YJ, Chung YS

Objectives Osteoporosis medications are widely available in South Korea, and well reimbursed by the Government Health Insurance; however, some expensive drugs are not reimbursed. The prescription of anti-osteoporosis drugs (AODs) are...
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Expression of Estrogen Receptor-alpha in Nasal Polyps and the Effects of Dexamethasone on Estrogen Receptoralpha Expression in RPMI 2650 Cells

Ban WW, Lee YJ, Lee SH, Jung JY, Baek BJ

Background: Studies have reported that epithelial cell proliferation may be involved in the pathogenesis of nasal polyps (NPs). Estrogen receptor (ER)-α, one type of ER, is related to antiinflammatory action...
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Growth and Bone Mineral Density Changes in Ovariectomized Rats Treated with Estrogen Receptor Alpha or Beta Agonists

Kang BH, Cho JH, Kim SY, Jeong KA, Kim SH, Kim C, Lim SJ, Shim KS

Background: Estrogen controls the pubertal growth spurt, growth plate closure, and accretion of bone mineral density (BMD) of long bones after biding estrogen receptor (ER). There are two subtypes of ER,...
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An Overview of Cancer Prevention: Chemoprevention and Immunoprevention

Gu KJ, Li G

ancer prevention encompasses a broad spectrum of strategies designed to lower the chance of developing cancer and reduce the morbidity of established cancer. There are three levels of cancer prevention....
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ESR1 Mutation Detection and Dynamicsin Meningeal Carcinomatosis in BreastCancer

Carausu M, Melaabi S, Pierga JY, Bidard FC, Cabel L

ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to...
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The Role of Long Noncoding RNAs in Antiestrogen Resistance in Breast Cancer: An Overview and Update

Huang L, Liang G, Zhang Q, Zhao W

As a standard treatment, endocrine therapy has dramatically enhanced the prognosis of patients with estrogen receptor (ER)-positive breast cancer, which accounts for nearly 70% of all breast cancers. Antiestrogen drugs...
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Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells

Chu C, Gao X, Li X, Zhang X, Ma R, Jia Y, Li D, Wang D, Xu F

Silibinin exhibits antidiabetic potential by preserving the mass and function of pancreatic β-cells through up-regulation of estrogen receptor-α (ERα) expression. However, the underlying protective mechanism of silibinin in pancreatic β-cells...
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17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells

Son HJ, Kim N, Song CH, Lee SM, Lee HN, Surh YJ

Background/Aims: Estrogen is known to have protective effect in colorectal cancer development. The aims of this study are to investigate whether estradiol treatment reduces inflammation in CCD841CoN, a female human...
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