Korean J Physiol Pharmacol.  1997 Apr;1(2):161-167.

Neural adaptation of beta adrenergic receptor subtypes after chronic imipramine treatment: A quantitative autoradiographic study

Affiliations
  • 1Department of Biochemistry, College of Medicine, Ewha Womans University , Seoul Natl. Inst., 110-799 Seoul South Korea.

Abstract

This study compares the subtypes of central beta adrenergic receptors (ARs) of brains of untreated rats with those of imipramine-treated rats. Beta adrenergic receptors were measured by quantitative autoradiography of the binding of 3H-dihydroalprenolol (3H-DHA) in coronal sections of rat brain. Repeated treatment of rats with imipramine significantly reduced the binding of 3H-DHA to beta-1 AR in many brain areas, especially throughout the cerebral cortex, hippocampus, thalamus, and amygdala. Significant reductions of the binding of 3H-DHA to beta-2 AR were not found in any area of the brain. These data suggests that a selective down-regulation of beta-1 AR may be involved in the adaptive changes occurring after prolonged imipramine treatment.

Keyword

Beta adrenergic receptor; Rat brain; Autoradigraphy; Imipramine

MeSH Terms

Amygdala
Animals
Autoradiography
Brain
Cerebral Cortex
Down-Regulation
Hippocampus
Imipramine*
Rats
Receptors, Adrenergic*
Receptors, Adrenergic, beta
Thalamus
Imipramine
Receptors, Adrenergic
Receptors, Adrenergic, beta
Full Text Links
  • KJPP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr