- Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of In Vivo Drug-Receptor Binding
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Yamada S, Kuraoka S, Osano A, Ito Y
- KMID: 2232961
- Int Neurourol J.
- 2012 Sep;16(3):107-115.
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed. Transdermal administration of oxybutynin... -
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- Rapid Changes in D1 and D2 Dopamine Receptor Binding in Striatal Subregions after a Single Dose of Phencyclidine
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Dalton VS, Zavitsanou K
- KMID: 2171262
- Clin Psychopharmacol Neurosci.
- 2011 Aug;9(2):67-72.
OBJECTIVE: In humans, a single exposure to phencyclidine (PCP) can induce a schizophrenia-like psychosis which can persist for up to two weeks. In rats, an acute dose of PCP increases... -
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- Imaging of Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression with Radiolabeled 5-(2-iodovinyl)-2'-deoxyuridine (IVDU) in Liver by Hydrodynamic-based Procedure
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Song I, Lee TS, Kang JH, Lee YJ, Kim KI, An GI, Chung WS, Cheon GJ, Choi CW, Lim SM
- KMID: 1841152
- Nucl Med Mol Imaging.
- 2009 Oct;43(5):468-477.
PURPOSE: Hydrodynamic-based procedure is a simple and effective gene delivery method to lead a high gene expression in liver tissue. Non-invasive imaging reporter gene system has been used widely with... -
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- Detection of Transferrin Receptor Over-Expression in a Rodent Model of Myocardial Ischemia/Reperfusion Injury Using Novel 99mTc Transferrin Conjugates: A Pilot Study
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Jeong HJ, Kim EM, Kim NH, Lee CM, Cheong SJ, Kim DW, Lim ST, Yoon KJ, Nah JW, Sohn MH
- KMID: 2225769
- Korean Circ J.
- 2008 Jul;38(7):360-365.
- doi: 10.4070/kcj.2008.38.7.360
BACKGROUND AND OBJECTIVES: Reperfusion of ischemic myocardium is necessary to salvage tissue from eventual death. However, new pathophysiological changes are initiated after reperfusion. The aim of this study was to... -
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- The Effect of Sevoflurane and Propofol on Expression of Inducible Nitric Oxide Synthase in Endotoxemic Rats
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Kim CH, Park JH, Baek SH, Baik SW
- KMID: 2228517
- Korean J Crit Care Med.
- 2004 Dec;19(2):106-114.
BACKGROUND: It is a well-known phenomenon that alveolar and peritoneal macrophages exposed to bacterial lipopolysaccharide (LPS) induce a large output of nitric oxide (NO) and an inducible nitric oxide synthase... -
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- Feasibility of Reflecting Improvement of Tumor Hypoxia by Mild Hyperthermia in Experimental Mouse Tumors with 18F-Fluoromisonidazole
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Lee SW, Ryu JS, Oh SJ, Im KC, Chen GJ, Lee SR, Song DY, Im SJ, Moon ES, Kim JH, Ahn SD, Shin SS, Lee KR, Moon DH, Choi EK
- KMID: 2198575
- J Korean Soc Ther Radiol Oncol.
- 2004 Dec;22(4):288-297.
PURPOSE: The aims of this study were to evaluate the change of [18F]fluoromisonidazole ([18F]FMISO) uptake in C3H mouse squamous cell carcinoma-VII (SCC-VII) treated with mild hyperthermia (42oC) and nicotinamide and... -
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- Electron Microscopic Autoradiographic Study on the Secretion of Atrial Specific Granules from Atrial Cardiocytes in Dehydrated Rats
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Shin HY, Song CH, Kim HT, Han EH, Lim JW, Lee MS
- KMID: 2224504
- Korean J Anat.
- 2004 Jun;37(3):241-253.
This study was performed to investigate for the effect of dehydration on the synthesis, secretion and secreted pathway of atrial specific granules contained ANP by electron microscopic autoradiography. Male Sprague-Dawley... -
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- The Effect of Glucose Concentration on Expression of VEGF and HGF in Cultured Human RPE Cells
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Baek CM, Lee HD, Kim KS
- KMID: 2337123
- J Korean Ophthalmol Soc.
- 2003 Nov;44(11):2652-2657.
PURPOSE: To evaluate the expression of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in response to high glucose concentration in human retinal pigement epithelial (RPE) cells. METHODS:... -
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- Preparation and Biodistribution of Re-188-Sulfur Colloid Suspension in Lipiodol
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Kim YJ, Jeong JM, Kim SK, Son M, Lee DS, Chung JK, Lee MC
- KMID: 2078743
- Korean J Nucl Med.
- 2003 Oct;37(5):301-307.
PURPOSE: Lipiodol is used for targeting liver cancers by administrating through the hepatic artery. In the present study, feasibility of Re-188-sulfur colloid suspension in lipiodol as a liver cancer targeting... -
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- Clinicopathological Characteristics of Sporadic Colorectal Cancer with DNA Microsatellite Instability
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Kim NK, Kim H, Park JK, Lee KY, Sohn SK, Min JS
- KMID: 1626387
- J Korean Soc Coloproctol.
- 2003 Feb;19(1):13-19.
PURPOSE: Sporadic colorectal cancers, with DNA microsatellite instability (MSI), have been characterized by a predilection area of proximal colon, younger age onset, exophytic growth and larger tumor size. MSI colorectal... -
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- Identification of SAP as a CTLA-4 Binding Molecule: a Role of SAP in CTLA-4 Signaling Proposed
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Lee KM
- KMID: 1571485
- Immune Netw.
- 2002 Jun;2(2):72-78.
- doi: 10.4110/in.2002.2.2.72
BACKGROUND: The precise mechanism by which CTLA-4 regulates T cell immune responses is still not fully understood. Previously we proposed that CTLA-4 could downregulate T cell function by modulating a... -
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- The Temporospatial Distribution of Glutamate Receptors and the Effect of MK-801 on Glutamate Receptors Activation in Kainate-induced Seizure Model: Quantitative Receptor Autoradiography of Ionotropic Glutamate Receptors
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Kim MK, Kim BC, Sohn EJ, Cho KH, Lee MC
- KMID: 2342953
- J Korean Neurol Assoc.
- 2002 Mar;20(2):179-186.
BACKGROUND: Excitotoxicity and epileptogenesis have often been associated with glutamate receptor activation. Some evidence indicates that selective down regulation of AMPA receptor may be the mechanism of delayed neuronal cell... -
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- Cadmium-induced Apoptosis in HL-60 Cells Via Signal Transduction
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Kim NS, Oh GJ, Cho KH, Hyun MS, Kim YC, Sung TH, Youm JH, Kwon KS
- KMID: 2028171
- Korean J Occup Environ Med.
- 2002 Mar;14(1):1-12.
OBJECTIVES: Apoptosis is a process of active cell death, distinct from necrosis and characterized by specific morphological and biochemical features. Apoptosis induced by metals and metal-related deleterious conditions has only... -
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- Chromatin Pattern-Dependent mRNA Synthesis in HeLa Cells and HeLa Tumors
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Lee JH, Kang MW, Choi C, Juhng SW
- KMID: 2172398
- Chonnam Med J.
- 2001 Dec;37(4):351-356.
Malignant cell nuclei, in general, have increased amount of heterochromatin and decreased electron density of euchromatin, making the chromatin pattern coarser than that of benign cell nuclei. Chromatin pattern in... -
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- The Effect of Vascular Endothelial Growth Factor and basic Fibroblast Growth Factor on the Growth of Endometrial Stromal Sarcoma
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Jeong J, Oh ST
- KMID: 2076392
- Korean J Obstet Gynecol.
- 2001 Nov;44(11):1953-1960.
OBJECTIVE: In order to investigate the role of VEGF and bFGF in endometrial stromal sarcoma(ESS). METHODS: We studied the effect of VEGF and bFGF on proliferation of endometrial stromal sarcoma... -
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- Effects of Bacillus Calmette-Guerin (BCG) on the Spleen of Mouse Inoculated with Ehrlich Carcinoma Cells: A Morphological Study
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Ko JS, Park SH, Ahn ET, Park KH, Kim JG
- KMID: 2092774
- Korean J Anat.
- 2001 Oct;34(5):451-465.
This experiment was performed to study the morphological responses of the spleen of mouse inoculated with Ehrlich carcinoma cells, following administration of Bacillus Calmette-Guerin (BCG). Healthy adult ICR mice weighing... -
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- Development of Mutation Scanning Method for the Molecular Diagnosis of beta-thalassemia using Dideoxy Fingerprinting (ddF)
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Joo SI, Park SS
- KMID: 1963108
- J Clin Pathol Qual Control.
- 2001 Jun;23(1):193-199.
BACKGROUND: beta-Thalassaemia is the most common single-gene disorders due to the mutations of the beta-globin gene. Because beta-thalassemic mutations are scattered throughout the beta-globin gene, mutation scanning technique may be... -
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- Change of alpha-SM Actin Expression Induced by the Antibody for TGF-beta in Fibroblast NIH3T3 Culture: The basic research for the inhibition of wound contracture
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Lee BH, Kang HK, Kim JJ, Kim DK, Yoon DW
- KMID: 1835259
- J Korean Soc Coloproctol.
- 2001 Jun;17(3):113-118.
PURPOSE: The purpose of this experiment is to measure the expression of TGF-beta and alpha-SM actin (smooth muscle actin) from fibroblast culture by the duration of culture days and to... -
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- mRNA is Synthesized Mainly at the Phase between the Euchromatin and Heterochromatin: Proposal of a Phase Theory
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Kim MS, Juhng SW
- KMID: 2275638
- Korean J Pathol.
- 2001 Apr;35(2):93-97.
BACKGROUND: Malignant cell nuclei, in general, have increased amounts of heterochromatin and decreased electron densities of euchromatin, making the chromatin pattern coarser than that of benign cell nuclei. The... -
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- Effects of Lower Dose-Injections of Acriflavine-Guanosine Compound (AG60) on the DNA Synthesis and Ultrastructure of the Ehrlich Carcinoma Cells Inoculated to the Mouse
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Ahn ET, Cheong KS, Ko JS, Park KH, Kim JG
- KMID: 2224527
- Korean J Anat.
- 2000 Dec;33(6):651-664.
AG60, a recently introduced anti-cancer compound, was reported to show highly effective anti-cancer activities, when injected with doses from 30 mg/kg to 5 mg/kg.The purpose of this study was to... -
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